Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells

2018 ◽  
Vol 65 ◽  
pp. 339-348 ◽  
Author(s):  
Hanlin Ou ◽  
Tangjian Cheng ◽  
Yumin Zhang ◽  
Jinjian Liu ◽  
Yuxun Ding ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cellular Uptake ◽  
Blood Circulation ◽  
Circulation Time

scholarly journals Synthesis, stability, cellular uptake, and blood circulation time of carboxymethyl-inulin coated magnetic nanoparticles

2013 ◽  
Vol 1 (22) ◽  
pp. 2807 ◽  
Author(s):  
Lenibel Santiago-Rodríguez ◽  
Moises Montalvo Lafontaine ◽  
Cristina Castro ◽  
Janet Méndez-Vega ◽  
Magda Latorre-Esteves ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cellular Uptake ◽  
Blood Circulation ◽  
Circulation Time

Nano Technological Approach for Anti-Tumor Therapy: Opportunities and Challenges

2020 ◽  
Vol 10 ◽  
Author(s):  
Krishna Champaneria ◽  
Prajesh Prajapati
Keyword(s):  
Adverse Effects ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Blood Circulation ◽  
Review Paper ◽  
Tumor Therapy ◽  
Conventional Chemotherapy ◽  
Targeting Delivery ◽  
Tumor Accumulation ◽  
Work Done

Cancer is one of the reason for mortality and its individual and collective impact is substantial. Conventional chemotherapy utilizes drugs that can destroy Tumor cells effectively. But these agents destroy healthy cells along with the tumor cells, leading to many adverse effects which include hypersensitivity reactions, nephrotoxicity, and neurotoxicity. To minimize the adverse effects, various drug delivery systems (DDSs) has been developed. Among them, nanoparticles are attractive platforms for it. So this review paper explores the recent work done on targeted delivery, enhancing tumor accumulation and longer blood circulation using more effective biomaterial that will enhance the properties of nanoparticles. Moreover, various target-specific delivery of drugs like antibody-targeted, targeting delivery through angiogenesis, mitochondria, CD44 receptor are also explained.

Icebreaker-inspired Janus nanomotors to combat barriers in the delivery of chemotherapeutic agents

Nanoscale ◽  
2021 ◽  
Author(s):  
Zhanlin Zhang ◽  
Dandan Zhang ◽  
Bo Qiu ◽  
Wenxiong Cao ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cancer Chemotherapy ◽  
Antineoplastic Agents ◽  
Blood Circulation ◽  
Chemotherapeutic Agents ◽  
Tumor Infiltration ◽  
Intracellular Release ◽  
Pass Through

Cancer chemotherapy remains challenging to pass through various biological and pathological barriers from blood circulation, tumor infiltration and cellular uptake before intracellular release of antineoplastic agents. Herein, icebreaker-inspired Janus nanomotors...

Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

2008 ◽  
Vol 1780 (4) ◽  
pp. 673-679 ◽  
Author(s):  
A. Kunwar ◽  
A. Barik ◽  
B. Mishra ◽  
K. Rathinasamy ◽  
R. Pandey ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cellular Uptake

scholarly journals Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Hao Qi ◽  
Hao Zhou ◽  
Qiyun Tang ◽  
Jee Young Lee ◽  
Zhiyuan Fan ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Blood Circulation ◽  
Circulation Time

A New Recombinant Fibronectin/Cadherin Protein-Hydrophobically Modified Glycol Chitosan/Paclitaxel Layer-By-Layer Self-Assembly Strategy for the Postoperative Therapy of Osteosarcoma and Correlated Bone Injury

2021 ◽  
Vol 17 (9) ◽  
pp. 1765-1777
Author(s):  
Zaiyang Liu ◽  
Yiqun Wu ◽  
Hongjuan Dai ◽  
Shasha Li ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Tumor Cells ◽  
Self Assembly ◽  
Blood Circulation ◽  
Residual Tumor ◽  
Layer By Layer ◽  
Glycol Chitosan ◽  
Hydrophobically Modified ◽  
Bone Injury

Osteosarcoma is one of the most aggressive cancers which greatly threatens the health of adolescents and surgery is difficult to resect the whole piece of tumor tissue. The residual tumor cells might proliferate at the tumor site and invade into the blood circulation, leading to tumor recurrence and metastasis. Besides, the invasion of tumor cells could also lead to bone injury. We designed a recombinant fibronectin-cadherin fusion protein/hydrophobically modified glycol chitosan-PTX nanoparticles (rFN-CDH/HGC-PTX) layer-by-layer self-assembly polymer based on biphasic calcium phosphate ceramic (BCP) (BCP-PEI-(rFN/CDH-PTX/HGC)n-rFN/CDH). The SEM, FTIR, XPS and contact angle experiments proved the successful synthesis of the polymer. The chemotherapy drug PTX and bone-repairing-related rFN/CDH fusion protein could be stably released within one week and the in vitro experiments exhibited the efficacy of the polymer to kill residual tumor cells and promote the proliferation of osteoblast, confirming that our polymer was a superior material for postoperative osteosarcoma therapy.

scholarly journals The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5072
Author(s):  
Xiaodong Li ◽  
Yanhong Sun ◽  
Lina Ma ◽  
Guifeng Liu ◽  
Zhenxin Wang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Blood Circulation ◽  
Time Window ◽  
Circulation Time ◽  
Great Success ◽  
Resonance Imaging ◽  
Enhanced Sensitivity ◽  
Magnetic Resonance Imaging Contrast

The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd3+) complex-based MRCAs have achieved great success in clinical practice, the Gd3+-complexes have several inherent drawbacks including Gd3+ leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation.

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