Cell-matrix mechanical interaction in electrospun polymeric scaffolds for tissue engineering: Implications for scaffold design and performance

2017 ◽  
Vol 50 ◽  
pp. 41-55 ◽  
Author(s):  
Kelsey M. Kennedy ◽  
Archana Bhaw-Luximon ◽  
Dhanjay Jhurry
Keyword(s):  
Tissue Engineering ◽  
Mechanical Interaction ◽  
Scaffold Design ◽  
Cell Matrix ◽  
Polymeric Scaffolds ◽  
And Performance

Chitosan/β-TCP composites scaffolds coated with silk fibroin: a bone tissue engineering approach

2021 ◽  
Vol 17 (1) ◽  
pp. 015003
Author(s):  
Lya Piaia ◽  
Simone S Silva ◽  
Joana M Gomes ◽  
Albina R Franco ◽  
Emanuel M Fernandes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Cellular Proliferation ◽  
Mechanical Performance ◽  
Tissue Growth ◽  
Polymeric Scaffolds ◽  
Bioactive Agents

Abstract Bone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable materials for bone regeneration solutions. The present work aimed to create chitosan/beta-tricalcium phosphate-based scaffolds coated with silk fibroin and evaluate their potential for bone tissue engineering. Results showed that the obtained scaffolds have porosities up to 86%, interconnectivity up to 96%, pore sizes in the range of 60–170 μm, and a stiffness ranging from 1 to 2 MPa. Furthermore, when cultured with MC3T3 cells, the scaffolds were able to form apatite crystals after 21 d; and they were able to support cell growth and proliferation up to 14 d of culture. Besides, cellular proliferation was higher on the scaffolds coated with silk. These outcomes further demonstrate that the developed structures are suitable candidates to enhance bone tissue engineering.

scholarly journals Mechanical Stimulation of Cells Through Scaffold Design for Tissue Engineering

2017 ◽  
Author(s):  
Carolina Oliver Urrutia ◽  
Ma. Victoria Dominguez-García ◽  
Jaime Flores-Estrada ◽  
Antonio Laguna-Camacho ◽  
Julieta Castillo-Cadena ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Mechanical Stimulation ◽  
Scaffold Design ◽  
Stimulation Of

Recent Advances in Biohybrid Materials for Tissue Engineering and Regenerative Medicine

2016 ◽  
Vol 04 (01) ◽  
pp. 1640001 ◽  
Author(s):  
Ying Wan ◽  
Xing Li ◽  
Shenqi Wang
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Cell Function ◽  
Rapid Prototype ◽  
Artificial Organs ◽  
Specific Cell ◽  
Cell Matrix ◽  
Matrix Surface ◽  
The Matrix ◽  
Cell Matrix Interactions

Biohybrid materials play an important role in tissue engineering, artificial organs and regenerative medicine due to their regulation of cell function through specific cell–matrix interactions involving integrins, mostly those of fibroblasts and myofibroblasts, and ligands on the matrix surface, which have become current research focus. In this paper, recent progress of biohybrid materials, mainly including main types of biohybrid materials, rapid prototype (RP) technique for construction of 3D biohybrid materials, was reviewed in detail; moreover, their applications in tissue engineering, artificial organs and regenerative medicine were also reviewed in detail. At last, we address the challenges biohybrid materials may face.

scholarly journals Maturation State-Dependent Alterations in Meniscus Integration: Implications for Scaffold Design and Tissue Engineering

2011 ◽  
Vol 17 (1-2) ◽  
pp. 193-204 ◽  
Author(s):  
Lara C. Ionescu ◽  
Gregory C. Lee ◽  
Grant H. Garcia ◽  
Tiffany L. Zachry ◽  
Roshan P. Shah ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Scaffold Design ◽  
State Dependent ◽  
Maturation State

Tissue engineering

2013 ◽  
pp. 664-668
Author(s):  
Andrew McCaskie ◽  
Paul Genever ◽  
Cosimo De Bari
Keyword(s):  
Tissue Engineering ◽  
Host Tissue ◽  
Target Tissue ◽  
Cell Therapies ◽  
Cell Matrix ◽  
Wide Range ◽  
Regenerative Approach ◽  
Great Relevance ◽  
Functional Interface

The field of tissue engineering has developed rapidly over the last few decades and is of great relevance to musculoskeletal therapy and intervention. Tissue engineering strategies are often considered in a simplified form in terms of cells, scaffolds, and additional factors, although it should be noted that successful translation of such a strategy is more complex. There are many variations of usage and combination and it is not necessary for all three to be provided by the proposed treatment. However, the regenerative approach must produce both the quantity and quality of target tissue at the level of the cell, matrix, and environment. Moreover, the regenerated tissue must interact with the host tissue with a seamless biological and functional interface. Tissue engineering, regenerative medicine, and cell therapies have developed significantly over the last few decades and are applicable to a wide range of musculoskeletal applications. Many strategies have been identified that would potentially benefit patients but the future will require successful translation from the laboratory into clinical practice. It is important to identify clinical targets where there is both clinical need and an informed view that the approach is likely to be successful.

Recent progress in 3D-printed polymeric scaffolds for bone tissue engineering

2020 ◽  
pp. 59-81 ◽  
Author(s):  
Pierre P.D. Kondiah ◽  
Yahya E. Choonara ◽  
Pariksha J. Kondiah ◽  
Thashree Marimuthu ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Recent Progress ◽  
Polymeric Scaffolds ◽  
3D Printed
Sign in / Sign up

Export Citation Format

Share Document