scholarly journals Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair

2015 ◽  
Vol 11 ◽  
pp. 27-36 ◽  
Author(s):  
Supansa Yodmuang ◽  
Stephanie L. McNamara ◽  
Adam B. Nover ◽  
Biman B. Mandal ◽  
Monica Agarwal ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Cartilage Tissue ◽  
Hydrogel Composites ◽  
Silk Hydrogel

Effects of in vitro low oxygen tension preconditioning of buccal fat pad stem cells on in Vivo articular cartilage tissue repair

Life Sciences ◽  
2021 ◽  
pp. 119728
Author(s):  
Fatemeh Dehghani Nazhvani ◽  
Leila Mohammadi Amirabad ◽  
Arezo Azari ◽  
Hamid Namazi ◽  
Simzar Hosseinzadeh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Tissue Repair ◽  
Cartilage Tissue ◽  
Low Oxygen ◽  
Fat Pad ◽  
Buccal Fat Pad ◽  
Low Oxygen Tension

scholarly journals Injectable stress relaxation gelatin-based hydrogels with positive surface charge for adsorption of aggrecan and facile cartilage tissue regeneration

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Kai-Yang Wang ◽  
Xiang-Yun Jin ◽  
Yu-Hui Ma ◽  
Wei-Jie Cai ◽  
Wei-Yuan Xiao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stress Relaxation ◽  
Tissue Repair ◽  
Cartilage Tissue ◽  
Regeneration Ability ◽  
Covalent Bonds ◽  
Differentiation Potential ◽  
Chondrocyte Viability ◽  
Cartilage Differentiation ◽  
And Cartilage

Abstract Background Cartilage injury and pathological degeneration are reported in millions of patients globally. Cartilages such as articular hyaline cartilage are characterized by poor self-regeneration ability due to lack of vascular tissue. Current treatment methods adopt foreign cartilage analogue implants or microfracture surgery to accelerate tissue repair and regeneration. These methods are invasive and are associated with the formation of fibrocartilage, which warrants further exploration of new cartilage repair materials. The present study aims to develop an injectable modified gelatin hydrogel. Method The hydrogel effectively adsorbed proteoglycans secreted by chondrocytes adjacent to the cartilage tissue in situ, and rapidly formed suitable chondrocyte survival microenvironment modified by ε-poly-L-lysine (EPL). Besides, dynamic covalent bonds were introduced between glucose and phenylboronic acids (PBA). These bonds formed reversible covalent interactions between the cis−diol groups on polyols and the ionic boronate state of PBA. PBA-modified hydrogel induced significant stress relaxation, which improved chondrocyte viability and cartilage differentiation of stem cells. Further, we explored the ability of these hydrogels to promote chondrocyte viability and cartilage differentiation of stem cells through chemical and mechanical modifications. Results In vivo and in vitro results demonstrated that the hydrogels exhibited efficient biocompatibility. EPL and PBA modified GelMA hydrogel (Gel-EPL/B) showed stronger activity on chondrocytes compared to the GelMA control group. The Gel-EPL/B group induced the secretion of more extracellular matrix and improved the chondrogenic differentiation potential of stem cells. Finally, thus hydrogel promoted the tissue repair of cartilage defects. Conclusion Modified hydrogel is effective in cartilage tissue repair.

scholarly journals Silk hydrogel for cartilage tissue engineering

2010 ◽  
Vol 95B (1) ◽  
pp. 84-90 ◽  
Author(s):  
Pen-Hsiu Grace Chao ◽  
Supansa Yodmuang ◽  
Xiaoqin Wang ◽  
Lin Sun ◽  
David L. Kaplan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Silk Hydrogel

scholarly journals Dual growth factor delivery from bilayered, biodegradable hydrogel composites for spatially-guided osteochondral tissue repair

Biomaterials ◽  
2014 ◽  
Vol 35 (31) ◽  
pp. 8829-8839 ◽  
Author(s):  
Steven Lu ◽  
Johnny Lam ◽  
Jordan E. Trachtenberg ◽  
Esther J. Lee ◽  
Hajar Seyednejad ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tissue Repair ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery ◽  
Biodegradable Hydrogel ◽  
Hydrogel Composites ◽  
Osteochondral Tissue

Diels–Alder crosslinked HA/PEG hydrogels with high elasticity and fatigue resistance for cell encapsulation and articular cartilage tissue repair

2014 ◽  
Vol 5 (17) ◽  
pp. 5116-5123 ◽  
Author(s):  
Feng Yu ◽  
Xiaodong Cao ◽  
Yuli Li ◽  
Lei Zeng ◽  
Jiehua Zhu ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Tissue Repair ◽  
Click Reaction ◽  
Gelation Time ◽  
Cell Encapsulation ◽  
Diels Alder ◽  
Cartilage Tissue ◽  
Peg Hydrogels ◽  
Cyclic Compression ◽  
High Elasticity

The gelation time of Diels–Alder crosslinked HA/PEG hydrogels can be reduced to an appropriate level for cell encapsulation and survival. At the same time, the DA click reaction makes the gel highly resilient and resistant to cyclic compression loading, which biomimics native articular cartilage biomechanical functions.

scholarly journals Key parameters of autologous biomedical product for cartilage tissue repair

2020 ◽  
Author(s):  
AV Eremeev ◽  
OA Zubkova ◽  
ES Ruchko ◽  
MA Lagarkova ◽  
VS Sidorov ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Hyaline Cartilage ◽  
Normal Function ◽  
Cartilage Tissue ◽  
Cartilage Defects ◽  
Pharmaceutical Drugs ◽  
Cell Product ◽  
Basic Parameters ◽  
Basic Characteristics ◽  
Registration Dossier

Repair of cartilage defects associated with injury or pathology is a clinically relevant problem. Chondral tissue, especially articular cartilages, has a poor regenerative potential. Inflammation triggers the growth of connective tissue, which cannot exert the normal function of the hyaline cartilage. This contributes to the progression of the pathology and eventually raises the need for surgery. At present, there are no pharmaceutical drugs capable of restoring the damaged cartilage. However, advances in cell-based technology hold promise for regenerative medicine. Reports describing fabrication of autologous cartilage transplants pose a special interest. A registration dossier of a biomedical cell product must contain the product’s specifications, presenting the basic characteristics of the product that can be used to assess its quality. This review looks at a few basic parameters that can be used to verify the authenticity of the cell product derived from autologous chondrocytes and describe its specifications.

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