Biological evaluation of an apatite–mullite glass-ceramic produced via selective laser sintering

2007 ◽  
Vol 3 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Ruth D. Goodridge ◽  
David J. Wood ◽  
Chikara Ohtsuki ◽  
Kenneth W. Dalgarno
Keyword(s):  
Glass Ceramic ◽  
Selective Laser Sintering ◽  
Biological Evaluation ◽  
Laser Sintering

Fabrication of Bioactive Glass-Ceramics by Selective Laser Sintering

2006 ◽  
Vol 309-311 ◽  
pp. 289-292
Author(s):  
Ruth D. Goodridge ◽  
Chikara Ohtsuki ◽  
Masanobu Kamitakahara ◽  
David J. Wood ◽  
Kenny W. Dalgarno
Keyword(s):  
Glass Ceramic ◽  
Selective Laser Sintering ◽  
Glass Ceramics ◽  
Ceramic Materials ◽  
Laser Sintering ◽  
Layer Manufacturing ◽  
Custom Made ◽  
Good Potential

The feasibility of processing glass-ceramics using the layer manufacturing technique, selective laser sintering (SLS), to produce parts with suitable biological and mechanical properties for use in bone replacement applications, has been investigated. Glass-ceramics derived from glasses based on several different systems have been considered. Initial experiments using an apatite-mullite glass-ceramic (4.5SiO2⋅3Al203⋅1.6P2O5⋅3CaO⋅2CaF2) demonstrated the ability to process glass-ceramic materials using this technique, creating parts with a strength similar to that of cancellous bone, and a porous structure that was shown in vivo to be suitable for the ingrowth of bone. Concerns over the inability of the apatite-mullite material to form an apatite layer on its surface when soaked in a simulated body fluid (SBF) has led to the development of Al2O3-free glasses based on the systems (50-x)CaO⋅45SiO2⋅5P2O5⋅xCaF2 and (48-x)CaO⋅45SiO2⋅5P2O5⋅2CaF2⋅xNa2O. These materials have demonstrated good in vitro bioactivity, and therefore have good potential as candidates for processing by an indirect SLS method for the production of custom-made bone implants.

scholarly journals Selective laser sintering of glass-ceramic bonds using a defocused Nd:YAG laser

2020 ◽  
Vol 2020 (1) ◽  
pp. 000286-000290
Author(s):  
K. Murawski ◽  
K. Aristovich ◽  
H.T. Lancashire
Keyword(s):  
Heat Source ◽  
Borosilicate Glass ◽  
Glass Ceramic ◽  
Nd:Yag Laser ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Alumina Ceramic ◽  
Implantable Electronics ◽  
Glass Paste ◽  
Optimal Effect

Abstract Protecting miniature implantable electronics may require mm scale hermetic packages. Glass-ceramic bonding by selective laser sintering of glass sealing paste using a defocused Nd:YAG laser is presented. Glass sealing paste (FX11-036, Ferro) is screen printed onto alumina ceramic, clamped in contact with borosilicate glass, and laser treated while heating to 250°C. With the addition of defocusing and a heat source the glass paste reflowed and wetted both the alumina and coverslip surfaces, with an optimal effect between 10 mm and 15 mm defocusing. This method is promising to create electrically non-conductive hermetic seals at the mm scale.

Manufacture and Characterisation of Bioceramic Tissue Engineering Scaffolds Produced by Selective Laser Sintering

2007 ◽  
Author(s):  
K. Xiao ◽  
J. A. Dyson ◽  
K. W. Dalgarno ◽  
P. Genever ◽  
D. J. Wood ◽  
...  
Keyword(s):  
Glass Ceramic ◽  
Selective Laser Sintering ◽  
Human Mesenchymal Stem Cells ◽  
Biological Properties ◽  
Laser Sintering ◽  
Process Conditions ◽  
Tissue Engineering Scaffolds ◽  
Process Maps ◽  
Bone Replacement ◽  
Porous Bioceramic

Currently there is no adequate bone replacement available that combines a long implant life with complete integration and appropriate mechanical properties. This paper reports on the use of human mesenchymal stem cells (MSCs) to populate porous bioceramic scaffolds produced by selective laser sintering (SLS) to create bespoke bioactive bone replacement structures. Apatite-wollastonite glass ceramic was chosen for use in this study because of its combination of excellent mechanical and biological properties, and has been processed using an indirect SLS approach. Process maps have been developed to identify process conditions for the SLS stage of manufacture and an optimised furnace cycle for the material has been developed to ensure that the required material phases for bioactivity are present in the manufactured scaffold. Results from tissue culture with the MSC’s on the scaffolds (using confocal and scanning electron microscopy) show that MSCs adhere, spread and retain viability on the surface, and penetrate into the pores of apatite wollastonite (A-W) glass ceramic scaffolds over a 21 day culture period. The MSC’s also show strong indications of osteogenesis, indicating that the MSC’s are differentiating to osteoblasts. These results indicate good biocompatibility and osteo supportive capacity of SLS generated A-W scaffolds and excellent potential in bone replacement applications.

scholarly journals Indirect selective laser sintering of apatite—wollostonite glass—ceramic

2008 ◽  
Vol 222 (7) ◽  
pp. 1107-1114 ◽  
Author(s):  
K Xiao ◽  
K W Dalgarno ◽  
D J Wood ◽  
R D Goodridge ◽  
C Ohtsuki
Keyword(s):  
Glass Ceramic ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Biological Properties ◽  
Laser Sintering ◽  
Bending Test ◽  
Processing Route ◽  
Test Results ◽  
Infiltration Process ◽  
Three Point Bending

This paper develops an indirect selective laser sintering (SLS) processing route for apatite—wollastonite (A—W) glass—ceramic, and shows that the processing route, which can create porous three-dimensional products suitable for bone implants or scaffolds, does not affect the excellent mechanical and biological properties of the glass—ceramic. ‘Green parts’ with fine integrity and well-defined shape have been produced from glass particles of single-size range or mixed-size ranges with acrylic binder in various ratios by weight. A subsequent heat treatment process has been developed to optimize the crystallization process, and an infiltration process has been explored to enhance mechanical strength. Three-point bending test results show flexural strengths of up to 102 MPa, dependent on porosity, and simulated body fluid (SBF) tests show that the laser sintered porous A—W has comparable biological properties to that of conventionally produced A—W.

Sign in / Sign up

Export Citation Format

Share Document