Combining competitive sequestration with nonlinear hybridization chain reaction amplification: an ultra-specific and highly sensitive sensing strategy for single-nucleotide variants

2020 ◽  
Vol 1130 ◽  
pp. 107-116
Author(s):  
Yan Zhao ◽  
Yuanbo Feng ◽  
Yuanbo Zhang ◽  
Pu Xia ◽  
Zihan Xiao ◽  
...  
Keyword(s):  
Hybridization Chain Reaction ◽  
Single Nucleotide Variants ◽  
Chain Reaction ◽  
Single Nucleotide ◽  
Highly Sensitive ◽  
Reaction Amplification

Highly sensitive SERS assay of genetically modified organisms in maize via a nanoflowers substrate coupling with hybridization chain reaction amplification

2021 ◽  
Author(s):  
Xinyu Zhou ◽  
Shengjie Ge ◽  
Yue Sun ◽  
Menglin Ran ◽  
Yifan Liu ◽  
...  
Keyword(s):  
Research Methods ◽  
Dna Sequences ◽  
Genetically Modified Organisms ◽  
Dna Detection ◽  
Genetically Modified ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Substrate Coupling ◽  
Highly Sensitive ◽  
Reaction Amplification

The research methods for DNA detection have been widely extended since the application of nanotechnology, but it remains a challenge to detect specific DNA sequences or low abundance genes in...

Lab in a tube: a fast-assembled colorimetric sensor for highly sensitive detection of oligonucleotides based on a hybridization chain reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44714-44721 ◽  
Author(s):  
Siqi Zhang ◽  
Kun Wang ◽  
Zhenyu Li ◽  
Zhongmin Feng ◽  
Ting Sun
Keyword(s):  
Complex Formation ◽  
Dna Sequence ◽  
Self Assembly ◽  
The Self ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
G Quadruplex ◽  
Colored Product ◽  
Highly Sensitive Detection

Upon adding THBV, the self-assembly of THBV with H1 allows the rest of the DNA sequence of H1 to accelerate H1–H2 complex formation. The G-quadruplex at the end of the H1–H2 complex could catalyze TMB into a colored product.

ICP-MS DNA assay based on lanthanide labels and hybridization chain reaction amplification

2015 ◽  
Vol 7 (14) ◽  
pp. 5767-5771 ◽  
Author(s):  
Chong Deng ◽  
Chong-Hua Zhang ◽  
Hao Tang ◽  
Jian-Hui Jiang
Keyword(s):  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Dna Assay ◽  
Icp Ms ◽  
Reaction Amplification

A novel ICP MS DNA assay based on lanthanide labels and hybridization chain reaction amplification has been developed.

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