Direct sample preparation and simultaneous perfluoroacylation - Trimethylsilylation of biogenic monoamines along with their acidic metabolites for a single step analysis by GC-MS

2020 ◽  
Vol 1127 ◽  
pp. 9-19
Author(s):  
Blanka Fodor ◽  
Elina Üveges ◽  
Ibolya Molnár-Perl
Keyword(s):  
Sample Preparation ◽  
Single Step ◽  
Biogenic Monoamines ◽  
Direct Sample

Introduction of a Novel Sample Preparation Technique for the Failure Analysis of Silicon Integrated Photonics Modules

2019 ◽  
Author(s):  
Pradip Sairam Pichumani ◽  
Fauzia Khatkhatay
Keyword(s):  
Sample Preparation ◽  
Failure Analysis ◽  
Silicon Photonics ◽  
Cmos Technology ◽  
Single Step ◽  
Oxide Semiconductor ◽  
Disruptive Technology ◽  
Preparation Technique ◽  
Test Vehicle ◽  
Sample Preparation Technique

Abstract Silicon photonics is a disruptive technology that aims for monolithic integration of photonic devices onto the complementary metal-oxide-semiconductor (CMOS) technology platform to enable low-cost high-volume manufacturing. Since the technology is still in the research and development phase, failure analysis plays an important role in determining the root cause of failures seen in test vehicle silicon photonics modules. The fragile nature of the test vehicle modules warrants the development of new sample preparation methods to facilitate subsequent non-destructive and destructive analysis methods. This work provides an example of a single step sample preparation technique that will reduce the turnaround time while simultaneously increasing the scope of analysis techniques.

The Role of Resolution and Sample Preparation in Hydration Rim Measurement: Implications for Experimentally Determined Hydration Rates

1988 ◽  
Vol 53 (1) ◽  
pp. 110-117 ◽  
Author(s):  
Barry E. Scheetz ◽  
Christopher M. Stevenson
Keyword(s):  
Activation Energy ◽  
Sample Preparation ◽  
Error Analysis ◽  
Single Step ◽  
Theoretical Limit

The role of the theoretical limit of resolution of optical microscopes is discussed in relation to obsidian rim age-date determinations. The resolution of the optics is shown to contribute an error of ± 20 percent. The error analysis identified the determination of the activation energy as the single step in the dating process that introduces the largest error.

Determination of Six Common Phthalate Plasticizers in Grain Neutral Spirits and Vodka

1995 ◽  
Vol 78 (3) ◽  
pp. 730-735 ◽  
Author(s):  
Jeffrey N Leebowitz ◽  
Rafael Sarmiento ◽  
Sumer M Dugar ◽  
Michael W Ethridge
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Liquid Chromatography ◽  
Sample Preparation ◽  
Sample Injection ◽  
Sample Enrichment ◽  
Injection Methods ◽  
No Sample Preparation ◽  
Direct Sample

Abstract Two direct sample injection methods using liquid chromatography (LC) and gas chromatography coupled with mass spectrometry (GC/MS) were used to determine phthalate residues in grain neutral spirits and vodka. Six reported phthalates were quantitated at concentrations as low as 20 μg/L (20 ppb) with no sample preparation or sample enrichment.

Determination of Squalene in Organic Extra Virgin Olive Oils (EVOOs) by UPLC/PDA Using a Single-Step SPE Sample Preparation

2016 ◽  
Vol 10 (5) ◽  
pp. 1377-1385 ◽  
Author(s):  
Andrea Salvo ◽  
Giovanna Loredana La Torre ◽  
Archimede Rotondo ◽  
Valentina Mangano ◽  
Katia Erminia Casale ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Single Step ◽  
Virgin Olive Oils ◽  
Olive Oils

scholarly journals Tissue pretreatment for LC–MS/MS analysis of PUFA and eicosanoid distribution in mouse brain and liver

2019 ◽  
Vol 412 (10) ◽  
pp. 2211-2223 ◽  
Author(s):  
Madlen Reinicke ◽  
Juliane Dorow ◽  
Karoline Bischof ◽  
Judith Leyh ◽  
Ingo Bechmann ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Sample Preparation ◽  
Tandem Mass Spectrometry ◽  
Sample Pretreatment ◽  
Single Step ◽  
Tandem Mass ◽  
Mediators Of Inflammation ◽  
Liquid Chromatography Tandem Mass ◽  
Negative Electrospray Ionization

AbstractPolyunsaturated fatty acids (PUFAs) and eicosanoids are important mediators of inflammation. The functional role of eicosanoids in metabolic-syndrome-related diseases has been extensively studied. However, their role in neuroinflammation and the development of neurodegenerative diseases is still unclear. The aim of this study was the development of a sample pretreatment protocol for the simultaneous analysis of PUFAs and eicosanoids in mouse liver and brain. Liver and brain samples of male wild-type C57BL/6J mice (11–122 mg) were used to investigate conditions for tissue rinsing, homogenization, extraction, and storage. A targeted liquid chromatography–negative electrospray ionization tandem mass spectrometry method was applied to quantify 7 PUFAs and 94 eicosanoids. The final pretreatment protocol consisted of a 5-min homogenization step by sonication in 650 μL n-hexane/2-propanol (60:40 v/v) containing 2,6-di-tert-butyl-4-methylphenol at 50 μg/mL. Homogenates representing 1 mg tissue were extracted in a single step with n-hexane/2-propanol (60:40 v/v) containing 0.1% formic acid. Autoxidation was prevented by addition of 2,6-di-tert-butyl-4-methylphenol at 50 μg/mL and keeping the samples at 4 °C during sample preparation. Extracts were dried under nitrogen and reconstituted in liquid chromatography eluent before analysis. Recovery was determined to range from 45% to 149% for both liver and brain tissue. Within-run and between-run variability ranged between 7% and 18% for PUFAs and between 1% and 24% for eicosanoids. In liver, 7 PUFAs and 15 eicosanoids were quantified; in brain, 6 PUFAs and 21 eicosanoids had significant differences within the brain substructures. In conclusion, a robust and reproducible sample preparation protocol for the multiplexed analysis of PUFAs and eicosanoids by liquid chromatography–tandem mass spectrometry in liver and discrete brain substructures was developed.

Electrochemical sensing of nitro-aromatic explosive compounds using silver nanoparticles modified electrochips

2016 ◽  
Vol 8 (39) ◽  
pp. 7158-7169 ◽  
Author(s):  
S. Singh ◽  
V. K. Meena ◽  
B. Mizaikoff ◽  
S. P. Singh ◽  
C. R. Suri
Keyword(s):  
Silver Nanoparticles ◽  
Sample Preparation ◽  
Electrochemical Deposition ◽  
Single Step ◽  
Electrochemical Sensing ◽  
Deposition Method ◽  
Minimal Sample ◽  
Screen Printed Electrodes ◽  
Electrochemical Deposition Method ◽  
Nitro Aromatic

In the present study an electrochemical deposition method for glycine-stabilized silver nanoparticles (Glyc-AgNPs) at screen printed electrodes in a single step with minimal sample preparation, is shown.

scholarly journals Liquid-phase microextraction of polycyclic aromatic hydrocarbons: A review

2020 ◽  
Vol 39 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Vahid Jalili ◽  
Abdullah Barkhordari ◽  
Alireza Ghiasvand
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Liquid Phase ◽  
Sample Preparation ◽  
Aromatic Hydrocarbons ◽  
Solid Phase ◽  
Endocrine Disrupting Chemicals ◽  
Single Step ◽  
Liquid Phase Microextraction ◽  
Polycyclic Aromatic ◽  
Conventional Methods

AbstractPolycyclic aromatic hydrocarbons (PAHs) are a large group of organic compounds comprised of two or more fused benzene rings, which arise from the incomplete combustion of organic materials. These compounds have been of concern as carcinogens and mutagens for the past 50-60 years. Lately, they are also receiving attention as endocrine-disrupting chemicals. Therefore, proper analytical methods are required for sampling and analyzing these compounds. In response to problems associated with the conventional methods like solid-phase extraction (SPE) and liquid-liquid extraction (LLE), many studies have focused on the miniaturization of different sample preparation techniques. In this regard, the use of different types of liquid phase microextraction (LPME) techniques has increased significantly during the recent few decades. LPME techniques are advantageous because they use single-step sample preparation and have shown a greater sensitivity, selectivity, and efficiency than the conventional methods. In addition, these techniques have good potential for automation, to reduce the time and cost of analysis. This review focuses on the most important configurations of LPME including single‐drop microextraction (SDME), hollow-fiber liquid-phase microextraction (HF-LPME), and dispersive liquid-liquid microextraction (DLLME) techniques used for the sampling and determination of PAHs in different samples, along with their cons and pros, as well as their prospects.

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