A freestanding all-solid-state polymeric membrane Cu2+-selective electrode based on three-dimensional graphene sponge

2019 ◽  
Vol 1068 ◽  
pp. 11-17 ◽  
Author(s):  
Jinghui Li ◽  
Wei Qin
Keyword(s):  
Solid State ◽  
Three Dimensional ◽  
Polymeric Membrane ◽  
Selective Electrode ◽  
Graphene Sponge

Factors Affecting the Potentiometric Response of All-Solid-State Solvent Polymeric Membrane Calcium-Selective Electrode for Low-Level Measurements

2004 ◽  
Vol 76 (21) ◽  
pp. 6410-6418 ◽  
Author(s):  
Anna Konopka ◽  
Tomasz Sokalski ◽  
Agata Michalska ◽  
Andrzej Lewenstam ◽  
Magdalena Maj-Zurawska
Keyword(s):  
Solid State ◽  
Polymeric Membrane ◽  
Selective Electrode ◽  
Factors Affecting ◽  
Low Level ◽  
Potentiometric Response

A Free Energy Perturbation Approach to Estimate the Intrinsic Solubilities of Drug-like Small Molecules

2019 ◽  
Author(s):  
Sayan Mondal ◽  
Gary Tresadern ◽  
Jeremy Greenwood ◽  
Byungchan Kim ◽  
Joe Kaus ◽  
...  
Keyword(s):  
Solid State ◽  
Small Molecules ◽  
Three Dimensional ◽  
Aqueous Solubility ◽  
Computational Approach ◽  
Free Energy Perturbation ◽  
Perturbation Approach ◽  
Energy Perturbation ◽  
State Form ◽  
Good Agreement

<p>Optimizing the solubility of small molecules is important in a wide variety of contexts, including in drug discovery where the optimization of aqueous solubility is often crucial to achieve oral bioavailability. In such a context, solubility optimization cannot be successfully pursued by indiscriminate increases in polarity, which would likely reduce permeability and potency. Moreover, increasing polarity may not even improve solubility itself in many cases, if it stabilizes the solid-state form. Here we present a novel physics-based approach to predict the solubility of small molecules, that takes into account three-dimensional solid-state characteristics in addition to polarity. The calculated solubilities are in good agreement with experimental solubilities taken both from the literature as well as from several active pharmaceutical discovery projects. This computational approach enables strategies to optimize solubility by disrupting the three-dimensional solid-state packing of novel chemical matter, illustrated here for an active medicinal chemistry campaign.</p>

One- and three-dimensional infinite arrays of Cu(i) ions exhibited by [Cu(NH3)2]Br and [Cu(NH3)Cl] in the solid state

2003 ◽  
pp. 956 ◽  
Author(s):  
Günter Margraf ◽  
Jan W. Bats ◽  
Michael Bolte ◽  
Hans-Wolfram Lerner ◽  
Matthias Wagner
Keyword(s):  
Solid State ◽  
Three Dimensional
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