scholarly journals Off-line mixed-mode liquid chromatography coupled with reversed phase high performance liquid chromatography-high resolution mass spectrometry to improve coverage in lipidomics analysis

2017 ◽  
Vol 954 ◽  
pp. 140-150 ◽  
Author(s):  
Mónica Narváez-Rivas ◽  
Ngoc Vu ◽  
Guan-Yuan Chen ◽  
Qibin Zhang
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Resolution ◽  
Mixed Mode ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Reversed Phase ◽  
High Resolution Mass ◽  
Resolution Mass

scholarly journals High performance liquid chromatography coupled with high resolution mass spectrometry-based characterization of lipidomic responses from rats with kidney injuries

RSC Advances ◽  
2018 ◽  
Vol 8 (36) ◽  
pp. 20250-20258
Author(s):  
Qun Liang ◽  
Han Liu ◽  
Xiuli Li ◽  
Yang Zhang
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Lipid Metabolism ◽  
High Resolution ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Resolution Mass

In this study, we present targeted and non-targeted lipidomics strategies to discover the lipid metabolism variation in serum in rats with sepsis-induced kidney injuries.

scholarly journals Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Orbitrap High-Resolution Mass Spectrometry for Multi-Residue Analysis of Mycotoxins and Pesticides in Botanical Nutraceuticals

Toxins ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 114 ◽  
Author(s):  
Alfonso Narváez ◽  
Yelko Rodríguez-Carrasco ◽  
Luigi Castaldo ◽  
Luana Izzo ◽  
Alberto Ritieni
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Resolution ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Residue Analysis ◽  
Food Supplements ◽  
High Resolution Mass ◽  
Resolution Mass

Cannabidiol (CBD) food supplements made of Cannabis sativa L. extracts have quickly become popular products due to their health-promoting effects. However, potential contaminants, such as mycotoxins and pesticides, can be coextracted during the manufacturing process and placed into the final product. Accordingly, a novel methodology using ultra-high-performance liquid chromatography coupled with quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was developed to quantify 16 mycotoxins produced by major C. sativa fungi, followed by a post-target screening of 283 pesticides based on a comprehensive spectral library. The validated procedure was applied to ten CBD-based products. Up to six different Fusarium mycotoxins were found in seven samples, the most prevalent being zearalenone (60%) and enniatin B1 (30%), both found at a maximum level of 11.6 ng/g. Co-occurrence was observed in four samples, including one with enniatin B1, enniatin A and enniatin A1. On the other hand, 46 different pesticides were detected after retrospective analysis. Ethoxyquin (50%), piperonyl butoxide (40%), simazine (30%) and cyanazine (30%) were the major residues found. These results highlight the necessity of monitoring contaminants in food supplements in order to ensure a safe consumption, even more considering the increase trend in their use. Furthermore, the developed procedure is proposed as a powerful analytical tool to evaluate the potential mycotoxin profile of these particular products.

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