RETRACTED: Rapid and effective sample cleanup based on graphene oxide-encapsulated core–shell magnetic microspheres for determination of fifteen trace environmental phenols in seafood by liquid chromatography–tandem mass spectrometry

2016 ◽  
Vol 919 ◽  
pp. 34-46 ◽  
Author(s):  
Sheng-Dong Pan ◽  
Xiao-Hong Chen ◽  
Hao-Yu Shen ◽  
Xiao-Ping Li ◽  
Mei-Qiang Cai ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Graphene Oxide ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Magnetic Microspheres ◽  
Core Shell ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

scholarly journals Graphene Oxide Tablets for Sample Preparation of Drugs in Biological Fluids: Determination of Omeprazole in Human Saliva for Liquid Chromatography Tandem Mass Spectrometry

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1191 ◽  
Author(s):  
Zeynab Zohdi ◽  
Mahdi Hashemi ◽  
Abdusalam Uheida ◽  
Mohammad Moein ◽  
Mohamed Abdel-Rehim
Keyword(s):  
Mass Spectrometry ◽  
Graphene Oxide ◽  
Liquid Chromatography ◽  
Sample Preparation ◽  
Tandem Mass Spectrometry ◽  
Human Saliva ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

In this study, a novel sort of sample preparation sorbent was developed, by preparing thin layer graphene oxide tablets (GO-Tabs) utilizing a mixture of graphene oxide and polyethylene glycol on a polyethylene substrate. The GO-Tabs were used for extraction and concentration of omeprazole (OME) in human saliva samples. The determination of OME was carried out using liquid chromatography-tandem mass spectrometry (LC–MS/MS) under gradient LC conditions and in the positive ion mode (ESI+) with mass transitions of m/z 346.3→198.0 for OME and m/z 369.98→252.0 for the internal standard. Standard calibration for the saliva samples was in the range of 2.0–2000 nmol L−1. Limits of detection and quantification were 0.05 and 2.0 nmol L−1, respectively. Method validation showed good method accuracy and precision; the inter-day precision values ranged from 5.7 to 8.3 (%RSD), and the accuracy of determinations varied from −11.8% to 13.3% (% deviation from nominal values). The extraction recovery was 60%, and GO-Tabs could be re-used for more than ten extractions without deterioration in recovery. In this study, the determination of OME in real human saliva samples using GO-Tab extraction was validated.

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