Novel redox species polyaniline derivative-Au/Pt as sensing platform for label-free electrochemical immunoassay of carbohydrate antigen 199

2016 ◽  
Vol 911 ◽  
pp. 108-113 ◽  
Author(s):  
Liyuan Wang ◽  
Jiao Shan ◽  
Feng Feng ◽  
Zhanfang Ma
Keyword(s):  
Carbohydrate Antigen ◽  
Electrochemical Immunoassay ◽  
Label Free ◽  
Redox Species ◽  
Sensing Platform ◽  
Polyaniline Derivative

Hollow metal–organic nanoparticles as redox species for label-free voltammetric immunoassay of prostate specific antigen

2017 ◽  
Vol 41 (3) ◽  
pp. 1124-1128 ◽  
Author(s):  
Weixiang Li ◽  
Qinfeng Rong ◽  
Zhanfang Ma
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Electrochemical Immunoassay ◽  
Label Free ◽  
Redox Species ◽  
Organic Nanoparticles ◽  
Metal Organic ◽  
Hollow Metal

A new redox species of hollow cadmium–organic coordination nanoparticles was prepared and was used to construct a redox substrate for label-free electrochemical immunoassay of PSA.

scholarly journals An Aptamer-Based Capacitive Sensing Platform for Specific Detection of Lung Carcinoma Cells in the Microfluidic Chip

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 98 ◽  
Author(s):  
Ngoc-Viet Nguyen ◽  
Chun-Hao Yang ◽  
Chung-Jung Liu ◽  
Chao-Hung Kuo ◽  
Deng-Chyang Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Carcinoma ◽  
Early Stage ◽  
A549 Cells ◽  
Microfluidic Channel ◽  
Electrical Impedance Spectroscopy ◽  
Label Free ◽  
Early Stage Lung Cancer ◽  
Sensing Platform ◽  
Label Free Detection

Improvement of methods for reliable and early diagnosis of the cellular diseases is necessary. A biological selectivity probe, such as an aptamer, is one of the candidate recognition layers that can be used to detect important biomolecules. Lung cancer is currently a typical cause of cancer-related deaths. In this work, an electrical sensing platform is built based on amine-terminated aptamer modified-gold electrodes for the specific, label-free detection of a human lung carcinoma cell line (A549). The microdevice, that includes a coplanar electrodes configuration and a simple microfluidic channel on a glass substrate, is fabricated using standard photolithography and cast molding techniques. A procedure of self-assembly onto the gold surface is proposed. Optical microscope observations and electrical impedance spectroscopy measurements confirm that the fabricated microchip can specifically and effectively identify A549 cells. In the experiments, the capacitance element that is dominant in the change of the impedance is calculated at the appropriate frequency for evaluation of the sensitivity of the biosensor. Therefore, a simple, inexpensive, biocompatible, and selective biosensor that has the potential to detect early-stage lung cancer would be developed.

scholarly journals A label-free phosphorescence sensing platform for trypsin based on Mn-ZnS QDs

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26930-26934 ◽  
Author(s):  
Wei Liu ◽  
Huanhuan Li ◽  
Yanli Wei ◽  
Chuan Dong
Keyword(s):  
Label Free ◽  
Sensing Platform ◽  
Phosphorescence Probe

A label-free phosphorescence strategy to determine trypsin was proposed using Mn-ZnS QDs as the phosphorescence probe with a better validity.

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