Setting local rank constraints by orthogonal projections for image resolution analysis: Application to the determination of a low dose pharmaceutical compound

2015 ◽  
Vol 892 ◽  
pp. 49-58 ◽  
Author(s):  
Mathieu Boiret ◽  
Anna de Juan ◽  
Nathalie Gorretta ◽  
Yves-Michel Ginot ◽  
Jean-Michel Roger
Keyword(s):  
Low Dose ◽  
Image Resolution ◽  
Orthogonal Projections ◽  
Pharmaceutical Compound ◽  
Resolution Analysis ◽  
Analysis Application ◽  
Rank Constraints ◽  
Local Rank

Effects of Liming and Fertilization on the Dehydrogenase and Catalase Activities

2019 ◽  
Vol 70 (10) ◽  
pp. 3464-3468
Author(s):  
Alina Dora Samuel ◽  
Simona Bungau ◽  
Ilona Katalin Fodor ◽  
Delia Mirela Tit ◽  
Cristian Felix Blidar ◽  
...  
Keyword(s):  
Soil Quality ◽  
Catalase Activity ◽  
Low Dose ◽  
Farmyard Manure ◽  
Enzymatic Activities ◽  
Mineral Fertilizers ◽  
Mineral Fertilization ◽  
Favorable Conditions ◽  
Npk Fertilization

In this paper we provide new data about the soil enzyme activity as a biological process, which is an indicator for impacts of factorial combinations of lime and fertilizers applications. Five plots divided into fifteen subplots were sampled for determination of the enzymatic indicators of soil quality, based on the actual and potential dehydrogenase and catalase activities. The research revealed that limed soil samples, in comparison with unlimed ones, resulted in significantly higher soil enzymatic activities (p[0.05) in the upper (0-20 cm), while in the deeper (20-40 cm) layer, only catalase activity was significantly higher (at least at p[0.02). Mineral fertilization, in comparison with its farmyard manuring, led to an insignificant increase in each of the three enzymatic activities determined, excepting catalase activity which was significantly higher (0.05]p]0.02) in the 0-20 cm layer. Based on the absolute values of the enzymatic activities, the enzymatic indicators of soil quality (EISQ) were calculated. The mineral NPK-fertilization and low dose of lime in the 0-20 cm layer, and mineral NP-fertilization and low dose of lime in the 20-40 cm layer proved to be the best variants of fertilization. The enzymatic indicators of soil quality in these variants reached the highest values: EISQ=0.821 and EISQ=0.889, respectively, indicating the presence of high enzymatic activities. It should be emphasized that a balanced application of lime, mineral fertilizers and farmyard manure leads to the formation of favorable conditions for the development of microorganisms, growth of plants and for an intense and lasting enzymatic activity.

The effect of experimental low zearalenone intoxication on ovarian follicles in pre-pubertal bitches

2013 ◽  
Vol 16 (1) ◽  
pp. 45-54 ◽  
Author(s):  
M. Gajęcka
Keyword(s):  
Low Dose ◽  
Companion Animals ◽  
Ovarian Follicles ◽  
Apoptotic Index ◽  
Proliferation Index ◽  
Control Group ◽  
Average Body ◽  
Proliferative Ability

AbstractCompanion animals, including bitches, may be exposed to zearalenone (ZEN) toxins that are often present in feed, and ZEN intoxication may lead to ovarian dysfunction. This study involved evaluation of the degree of ZEN-induced hypo stimulation of ovary by determination of proliferative and apoptotic indices and description of the ultra-structural organization of ovarian follicles in pre-pubertal bitches subjected to experimental, long-term exposure to low-dose ZEN mycotoxicosis. The experiment involved 30 clinically healthy, immature Beagle bitches aged approximately 70 days with initial average body weight of 8 kg, randomly divided into three groups of 10 animals each: two experimental groups (EI and EII) and a control group (C). Over a period of 42 days, ZEN was administered per os to EI animals at a dose of 50 μg/kg BW, and to EII bitches at a dose of 75 μg/kg BW. Control group animals were fed placebo containing no ZEN for 42 days. Analytical samples of the mycotoxin were administered daily in gelatin capsules before morning feeding. All the bitches were subjected to ovario-hysterectomy at the end of the experiment. Proliferation index (PCNA method) and apoptotic index (TUNEL test) values were determined by immune-histological analyses. The median for apoptotic index was determined at 13.45 for group EI, 17.84 for group EII, and 8.59 for group C. The median for proliferation index was determined at 35.25 for group EII, 42.44 for group EI, and 70.60 for group C. The results of ultra-structural examinations of the ovaries revealed that experimental, ZEN-induced hyperestrogenism enhanced apoptosis and lowered the proliferative ability of follicular cells what contributed to organelle destruction in pre-pubertal bitches. The changes observed were particularly advanced in EII animals, which were administered a higher dose of ZEN.

Super-Resolution Analysis on Molten Pool Image of Metal Active-Gas Welding Based on Wavelet with Fractal

2011 ◽  
Vol 103 ◽  
pp. 152-157
Author(s):  
Guang Zhi Dai ◽  
Guo Qiang Han ◽  
Chao Yi Dong
Keyword(s):  
Image Processing ◽  
Super Resolution ◽  
Image Interpolation ◽  
Image Resolution ◽  
Mag Welding ◽  
Resolution Image ◽  
Fractal Image ◽  
Welding Image ◽  
Resolution Analysis ◽  
Wavelet Image

According to the unique advantages in image processing combining wavelet and fractal and the different ways of combination, a super-resolution image processing methods are proposed. The methods are characterized by combining the wavelet transform, Wavelet Image Interpolation and FBM Fractal Image interpolation in a certain way to achieve super-resolution image reconstruction. Through processing MAG welding pool images polluted by noises seriously, the results show that: the method proposed in this paper, compared with the method based on wavelet bilinear interpolation, not only effectively raises MAG welding image resolution, but also PSNR of reconstruction images are enhanced 21.1049 dB.

scholarly journals Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2716 ◽  
Author(s):  
Tun-Pin Hsueh ◽  
Tung-Hu Tsai
Keyword(s):  
Bioactive Compounds ◽  
Pharmacokinetic Study ◽  
High Performance ◽  
Low Dose ◽  
Rat Plasma ◽  
Herbal Formula ◽  
Preclinical Pharmacokinetics ◽  
Pharmacokinetic Properties ◽  
Liquid Chromatography Tandem Mass

The herbal formula Yin-Chen-Hao-Tang has been reported to have anti-fibrosis properties. The aim of this study was to reveal the pharmacokinetic characteristics of bioactive compounds in this herbal formula. A new high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous determination of scoparone, geniposide and rhein in rat plasma. A pharmaceutical herbal powder was administered to rats at doses of 1 g/kg and 3 g/kg orally. The method showed excellent linearity (r2 > 0.999) and validation was successfully conducted for the pharmacokinetic study. The results show that the Cmax values and areas under the curve of scoparone, geniposide and rhein were higher and not proportional to the dose in rat plasma, while the Tmax and half-life values were consistent in the group that received 1 g/kg. The clearance of the higher dose (3 g/kg) did not decrease proportionally to that of the low dose. The results showed the nonlinear pharmacokinetic properties of scoparone, geniposide and rhein in Yin-Chen-Hao-Tang that suggested possible accumulation of bioactive compounds through oral administration. This pharmacokinetic study reveals that an increased dose of this herbal formula would largely increase the maximum concentration and bioavailability of scoparone, geniposide and rhein.

Sign in / Sign up

Export Citation Format

Share Document