Performance of the linear ion trap Orbitrap mass analyzer for qualitative and quantitative analysis of drugs of abuse and relevant metabolites in sewage water

2013 ◽  
Vol 768 ◽  
pp. 102-110 ◽  
Author(s):  
Lubertus Bijlsma ◽  
Erik Emke ◽  
Félix Hernández ◽  
Pim de Voogt
Keyword(s):  
Quantitative Analysis ◽  
Drugs Of Abuse ◽  
Ion Trap ◽  
Sewage Water ◽  
Mass Analyzer ◽  
Linear Ion Trap ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Orbitrap Mass Analyzer

scholarly journals Investigation of Drug-Packaging Interactions with Mass Spectroscopy Detectors: A Meta-Synthesis of the Literature

2019 ◽  
Vol 4 (1) ◽  
pp. 3-14 ◽  
Author(s):  
Camille Fauchere ◽  
Markoulina Berger-Gryllaki ◽  
Farshid Sadeghipour
Keyword(s):  
Quantitative Analysis ◽  
Food Packaging ◽  
Ion Trap ◽  
Pharmaceutical Products ◽  
Triple Quadrupole ◽  
Qualitative And Quantitative Analysis ◽  
Inclusion Criteria ◽  
Qualitative And Quantitative ◽  
Drug Packaging ◽  
English Articles

Abstract Background The production of hospital-compounded medicines with a longer shelf life raises questions about drug-packaging interactions, especially desorption events involving extractables and leachables (E/L). A meta-synthesis of the literature was performed to describe which mass spectrometer is suitable for identifying and quantifying E/L. Methods A meta-synthesis of studies focused on the identification or quantification of E/L published between January 1997 and December 2017 was performed. Inclusion criteria were E/L studies dealing with pharmaceutical products, in which mass spectrometry (MS) coupled to liquid chromatography (LC) or gas chromatography (GC) was used. The full-text articles had to be available and written in English. Articles about food packaging, environmental contamination, counterfeit compounds, pharmacokinetics, or process-related impurity studies were excluded. Two researchers independently assessed the papers according to a score based on a seven-item questionnaire. Results In total, 32 papers matched our criteria and were included in the meta-synthesis. For qualitative analysis with LC, quadrupole time-of-flight (QTOF; n=4) and ion trap (n=4) mass detectors were used the most; and with GC, single quadrupole (n=8). For quantification studies with LC, QTOF (n=3) and triple quadrupole (n=2) were used the most; and with GC, single quadrupole (n=7). Conclusions For simultaneous qualitative and quantitative analysis of E/L with LC, QTOF or Orbitrap is a suitable detector. For quantitative analysis with LC only, triple quadrupole is suitable. For qualitative and quantitative analysis with GC, single quadrupole can be used.

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