An overview of the analytical methods for the determination of organic ultraviolet filters in biological fluids and tissues

2012 ◽  
Vol 752 ◽  
pp. 11-29 ◽  
Author(s):  
Alberto Chisvert ◽  
Zacarías León-González ◽  
Isuha Tarazona ◽  
Amparo Salvador ◽  
Dimosthenis Giokas
Keyword(s):  
Analytical Methods ◽  
Biological Fluids

A Review of Analytical Methods for the Determination of Tibolone: Pharmacokinetics and Pharmaceutical Formulations Analysis and Application in Doping Control

2020 ◽  
Vol 17 (1) ◽  
pp. 31-39
Author(s):  
Marilene Lopes Ângelo ◽  
Fernanda de Lima Moreira ◽  
Ana Laura Araújo Santos ◽  
Hérida Regina Nunes Salgado ◽  
Magali Benjamim de Araújo
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
Estrogenic Activity ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Doping Control ◽  
Specific Effects ◽  
In Doping

Background:: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims:: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacokinetics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and conclusions: : The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.

scholarly journals An Overview of the Analytical Methods for the Determination of Organic Ultraviolet Filters in Cosmetic Products and Human Samples

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4780
Author(s):  
Izabela Narloch ◽  
Grażyna Wejnerowska
Keyword(s):  
Analytical Methods ◽  
Limit Of Detection ◽  
Biological Fluids ◽  
Analytical Techniques ◽  
Detection Accuracy ◽  
Uv Filters ◽  
Cosmetic Products ◽  
Monitoring Protocols ◽  
Accuracy And Repeatability

UV filters are a group of compounds commonly used in different cosmetic products to absorb UV radiation. They are classified into a variety of chemical groups, such as benzophenones, salicylates, benzotriazoles, cinnamates, p-aminobenzoates, triazines, camphor derivatives, etc. Different tests have shown that some of these chemicals are absorbed through the skin and metabolised or bioaccumulated. These processes can cause negative health effects, including mutagenic and cancerogenic ones. Due to the absence of official monitoring protocols, there is an increased number of analytical methods that enable the determination of those compounds in cosmetic samples to ensure user safety, as well as in biological fluids and tissues samples, to obtain more information regarding their behaviour in the human body. This review aimed to show and discuss the published studies concerning analytical methods for the determination of organic UV filters in cosmetic and biological samples. It focused on sample preparation, analytical techniques, and analytical performance (limit of detection, accuracy, and repeatability).

Overview of the Chromatographic and Mass Spectrometry Analytical Methods for Determination of Lamivudine in Biological Fluids

2019 ◽  
Vol 15 (2) ◽  
pp. 103-108
Author(s):  
Xuwang Chen ◽  
Fanlong Bu ◽  
Rong Li ◽  
Guiyan Yuan ◽  
Yanyan Wang ◽  
...  
Keyword(s):  
United States ◽  
Mass Spectrometry ◽  
Clinical Practice ◽  
Analytical Methods ◽  
Review Paper ◽  
Biological Fluids ◽  
Animal Experiments ◽  
The United States ◽  
Therapeutic Drug

Background: Lamivudine was approved by Food and Drug Administration of the United States for the treatment of both HIV and HBV infection, which has been widely used as monotherapy or a component of combination therapy in clinics in many countries and nationalities. Methods: In this paper, the recent chromatographic and mass spectrometry analytical methods for the determination of lamivudine individually or combination with other drugs simultaneously were presented. These methods were widely applied in pharmacokinetics studies, bioequivalence studies, therapeutic drug monitoring studies, cell and animal experiments. Conclusion: The review paper might provide references for determining lamivudine in biological fluids, the intracorporal process of lamivudine, and the clinical practice by monitoring plasma concentration of lamivudine in the future.

Proton pump inhibitors: recent developments in analytical methodologies

2015 ◽  
Vol 34 (1-2) ◽  
Author(s):  
Mehul M. Patel ◽  
Satish D. Bhuva ◽  
Miketa M. Patel
Keyword(s):  
Liquid Chromatography ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Analytical Methods ◽  
High Performance ◽  
Biological Fluids ◽  
Ultra Violet ◽  
Analytical Techniques ◽  
Pharmaceutical Chemistry

AbstractAn extensive survey of the literature published in various analytical and pharmaceutical chemistry-related journals have been conducted, and the instrumental analytical methods that were developed and used for the determination of proton pump inhibitors in bulk drugs, formulations, and biological fluids have been reviewed. This review covers the time period from 1990 to 2011 during which 80 analytical methods, including all types of spectrophotometric and chromatographic techniques were reported. High-performance liquid chromatography (HPLC) with ultra violet (UV) detection was found to be the technique of choice for many workers, and more than 50 methods were based on liquid chromatography (LC) and ultra violet (UV). A critical analysis of the reported data was carried out and the present state of the art of the analytical techniques for the determination of omeprazole, esomeprazole, pantoprazole, rabeprazole, dexrabeprazole, tenatoprazole, lansoprazole, and dexlansoprazole is discussed.

Analytical methods for the quantification of cisplatin, carboplatin, and oxaliplatin in various matrices over the last two decades

2021 ◽  
Vol 18 ◽  
Author(s):  
Hajer Hrichi ◽  
Noura Kouki ◽  
Haja Tar
Keyword(s):  
Analytical Methods ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Atomic Absorption Spectrophotometry ◽  
Literature Reviews ◽  
Small Doses ◽  
Inherent Problem ◽  
Uv Visible ◽  
Accurate Quantification

Background: Platinum derivatives including cisplatin and its later generations carboplatin, and oxaliplatin remain the most largely used drugs in the therapy of malignant diseases. They exert notable anticancer activity towards numerous types of solid tumors such as gastric, colorectal, bladder, ovary, and several others. The chemotherapeutic activity of these compounds, however, is associated with many unwanted side effects and drug resistance problems limiting their application and effectiveness. Proper dosage is still an inherent problem, as these drugs are usually prescribed in small doses. Objective: Several analytical methods have been reported for the accurate quantification of cisplatin, carboplatin, and oxaliplatin and their metabolites either alone or in combination with other chemotherapeutic drugs, in different matrices such as pharmaceutical formulations, biological fluids, cancer cells, and environmental samples. The main goal of this review is to systematically study the analytical methods already used for the analysis of cisplatin, carboplatin, and oxaliplatin in various matrices during the last two decades. Results and Conclusion: In the literature, reviews showed that numerous analytical methods such as electroanalytical, UV-visible spectrophotometry, chromatographic, fluorescence, atomic absorption spectrophotometry, and other spectroscopic methods combined with mass spectrometry were used for the determination of these compounds in various matrices.

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