Analysis of urinary neurotransmitters by capillary electrophoresis: Sensitivity enhancement using field-amplified sample injection and molecular imprinted polymer solid phase extraction

2011 ◽  
Vol 699 (2) ◽  
pp. 242-248 ◽  
Author(s):  
Bérengère Claude ◽  
Reine Nehmé ◽  
Philippe Morin
Keyword(s):  
Capillary Electrophoresis ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Sensitivity Enhancement ◽  
Phase Extraction ◽  
Molecular Imprinted Polymer ◽  
Imprinted Polymer ◽  
Sample Injection

scholarly journals DEVELOPMENT OF MOLECULAR IMPRINTED POLYMER SOLID PHASE EXTRACTION (MISPE) FOR SEPARATION NITROFURANTOIN RESIDUE IN CHICKEN EGGS

2017 ◽  
Vol 10 (6) ◽  
pp. 108
Author(s):  
Sophi Damayanti ◽  
Untung Gunawan ◽  
Slamet Ibrahim
Keyword(s):  
Solid Phase Extraction ◽  
Analytical Methods ◽  
Density Functional ◽  
Solid Phase ◽  
Basis Set ◽  
Phase Extraction ◽  
Molecular Imprinted Polymer ◽  
Imprinted Polymer ◽  
Dft Methods ◽  
The Matrix

Background: The use of nitrofurantoin and other nitrofuran antibiotics in food which produced from animals is prohibited by European Union because of potentially carcinogenic and mutagenic. Various methods for analysis of residues of nitrofurantoin has been developed, but because of the interference of the matrix, it is necessary to separate the matrix therefore, the matrix effect will not interfere the analysis. Nowadays, molecular imprinted polymer (MIP) is a well-developed tool in the analytical field, mainly for separating substances in relatively complex matrices.Objective: The purpose of this study is to obtain MISPE that is selective for the separation of nitrofurantoin residues in chicken eggs.Methods: Analytical methods development of nitrofurantoin were optimization of HPLC system and validation of analytical methods performed to obtain the suitable system for nitrofurantoin detection. In silico study used for MIP design by observing the difference Gibbs free energy using Gaussview 5.08 software with Density Functional Theory (DFT) methods using 6-311G as basis set. MIP synthesis was done using bulk method use nitrofurantoin as template, acrylamide as functional monomer, ethyleneglycoldimethacrylate (EGDMA) as crosslinker, and azobisisobutyronitrile (AIBN) as an initiator reaction inside dimethylformamide (DMF) as solvent. Non imprinted polymer (NIP) was synthesized as comparison. MIP and NIP which has been synthesized was inserted into SPE cartridge and characterized using Infrared spectroscopy and HPLC.Result: MISPE that has been synthesized was characterized and compared to non-imprinted polymer solid phase extraction (NISPE) and marketed Solid Phase Extraction (SPE) C18. Sensitivity of MIP, NIP, and SPE C-18 to nitrofurantoin was 84.54 %, 37.73 %, and 33.95 % respectively, based on recovery of nitrofurantoin.Conclusion: Based on the result it was obtained MISPE has high selectivity toward nitrofurantoin compared to NISPE and either marketed SPE.  

Analysis of triazolopyrimidine herbicides in soils using field-enhanced sample injection-coelectroosmotic capillary electrophoresis combined with solid-phase extraction

2005 ◽  
Vol 1100 (2) ◽  
pp. 236-242 ◽  
Author(s):  
Javier Hernández-Borges ◽  
Francisco J. García-Montelongo ◽  
Alejandro Cifuentes ◽  
Miguel Ángel Rodríguez-Delgado
Keyword(s):  
Capillary Electrophoresis ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Phase Extraction ◽  
Sample Injection

Molecular imprinted polymer for solid-phase extraction of flavonol aglycones from Moringa oleifera extracts

2012 ◽  
Vol 36 (3) ◽  
pp. 548-555 ◽  
Author(s):  
Vusumzi Pakade ◽  
Ewa Cukrowska ◽  
Sofia Lindahl ◽  
Charlotta Turner ◽  
Luke Chimuka
Keyword(s):  
Solid Phase Extraction ◽  
Moringa Oleifera ◽  
Solid Phase ◽  
Phase Extraction ◽  
Molecular Imprinted Polymer ◽  
Imprinted Polymer
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