Simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine Xian Ling Gu Bao capsule by using HPLC-DAD coupled with alternating trilinear decomposition algorithm

2009 ◽  
Vol 650 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Li-Qun Ouyang ◽  
Hai-Long Wu ◽  
Jin-Fang Nie ◽  
Yan Zhang ◽  
Hong-Yan Zou ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Simultaneous Determination ◽  
Decomposition Algorithm ◽  
Trilinear Decomposition ◽  
Alternating Trilinear Decomposition

Simultaneous Determination of Eight Potential Q-Markers in Zishen Tongguan Capsules Based on UHPLC-MS/MS

2020 ◽  
Vol 17 (1) ◽  
pp. 47-56
Author(s):  
Shun Liu ◽  
Xun Wang ◽  
Kaiping Zou ◽  
Wei Liu ◽  
Cunyu Li ◽  
...  
Keyword(s):  
Quality Control ◽  
Chinese Medicine ◽  
Simultaneous Determination ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Gradient Elution ◽  
Quality Markers ◽  
High Repeatability ◽  
Comprehensive Study

Background: Zishen Tongguan (ZSTG) capsules were prepared at the Affiliated Hospital of Nanjing University of Chinese Medicine and have been proven to be clinically effective for treating pyelonephritis and benign prostatic hyperplasia. However, the quality standards are not ideal; a comprehensive study of the “quality markers” (Q-markers), the chemicals inherent in traditional Chinese medicine and its preparations, has not been carried out. Experimental Methods: In this paper, a sensitive and specific ultra-high-performance liquid chromatographictandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of eight potential Q-markers of ZSTG, including timosaponin A3, berberine, jatrorrhizine, phellodendrine, palmatine, mangiferin, neomangiferin, and timosaponin BII. A Kromasil 100-3.5 C18 column was used with a mobile phase of 0.2% formic acid with acetonitrile, and gradient elution at a flow rate of 0.2 mL/min was achieved in 13 minutes and used for separation. Detection was performed in positive/negative mode with multiple reaction monitoring (MRM). Results: The analytical method was validated in terms of the sensitivity, linearity, accuracy, precision, repeatability, stability and recovery. The method established here was successfully applied to study the potential Q-markers in 8 batches of commercial samples, which demonstrated its use in improving the quality control of ZSTG. Conclusion: The developed method had high repeatability and accuracy and was suitable for the simultaneous analysis of multiple Q-markers, which may provide a new basis for the comprehensive assessment and overall quality control of ZSTG.

Rapid determination of sulfamethoxazole and trimethoprim illegally added into health products using excitation-emission matrix fluorescence coupled with second-order calibration method

2021 ◽  
Author(s):  
Lu-Zhu Chen ◽  
Hai-Long Wu ◽  
WanJun Long ◽  
Tong Wang ◽  
Gao-Yan Tong ◽  
...  
Keyword(s):  
Analytical Method ◽  
Rapid Determination ◽  
Calibration Method ◽  
Trilinear Decomposition ◽  
Excitation Emission Matrix ◽  
Health Products ◽  
Alternating Trilinear Decomposition ◽  
Second Order Calibration ◽  
Eem Fluorescence

In this work, a simple and fast analytical method based on self-weighted alternating trilinear decomposition (SWATLD) algorithm coupled with excitation-emission matrix (EEM) fluorescence was developed for the simultaneous determination of...

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