Rapid method for the determination of non-steroidal anti-inflammatory drugs in animal tissue by liquid chromatography–mass spectrometry with ion-trap detector

2007 ◽  
Vol 586 (1-2) ◽  
pp. 432-439 ◽  
Author(s):  
Carmen Igualada ◽  
Francisco Moragues ◽  
Jorge Pitarch
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Rapid Method ◽  
Ion Trap ◽  
Animal Tissue ◽  
Liquid Chromatography Mass Spectrometry ◽  
Trap Detector ◽  
Chromatography Mass Spectrometry ◽  
Inflammatory Drugs

scholarly journals Determination of Chlormequat in Pears by Liquid Chromatography/Mass Spectrometry

2000 ◽  
Vol 83 (3) ◽  
pp. 742-747 ◽  
Author(s):  
Hans G J Mol ◽  
Ruud C J Van Dam ◽  
Rob J Vreeken ◽  
Odile M Steijger
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Trap ◽  
Triple Quadrupole ◽  
Liquid Chromatography Mass Spectrometry ◽  
Liquid Chromatograph ◽  
Triple Quadrupole Instrument ◽  
Chromatography Mass Spectrometry ◽  
Quadrupole Instrument

Abstract A straightforward and reliable method was developed for the determination of chlormequat in pears by liquid chromatography/mass spectrometry (LC/MS). Water and methanol were compared as extraction solvents. Because no significant differences in extraction efficiency or repeatability were found, water was chosen as the extraction solvent. The extracts were analyzed without cleanup by either an ion-trap liquid chromatograph/mass spectrometer in the single MS mode or a triple-quadrupole instrument in the MS/MS mode, using electrospray ionization. Both instruments were equally suitable for quantitation and confirmation of identity. Recoveries were 76–103%, and reproducibility was ≤12%. The lowest detection limit (0.007 mg/kg) was obtained with the triple-quadrupole instrument in the MS/MS mode.

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