Determination and antioxidant activity evaluation of etodolac, an anti-inflammatory drug, by sequential injection analysis

2006 ◽  
Vol 573-574 ◽  
pp. 371-375 ◽  
Author(s):  
Julia B. Garcia ◽  
M. Lúcia M.F.S. Saraiva ◽  
José L.F.C. Lima
Keyword(s):  
Antioxidant Activity ◽  
Sequential Injection Analysis ◽  
Sequential Injection ◽  
Inflammatory Drug ◽  
Activity Evaluation ◽  
Anti Inflammatory

scholarly journals In Silico and In Vitro Analysis of the 4,4′,4′′-((1,3,5-Triazine-2,4,6-triyl)tris(azanediyl))triphenol), an Antioxidant Agent with a Possible Anti-Inflammatory Function

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Ricardo I. Castro ◽  
Felipe Valenzuela-Riffo ◽  
Luis Morales-Quintana
Keyword(s):  
Antioxidant Activity ◽  
Cell Damage ◽  
Drug Candidate ◽  
Hemolysis Assay ◽  
Inflammatory Drug ◽  
Ligand Interactions ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Vitro Analysis

Inflammation is a consequence of an array of biological reactions that occur in response to pain sensation, local injury, and cell damage. A large number of studies have demonstrated that quercetin and other flavonoids show anti-inflammatory effects; thus, in the present work, we evaluated a triazine-phenol derivative (TP derivative) compound as a possible drug candidate with anti-inflammatory activity. This compound was studied as a possible anti-inflammatory drug using synthesis and characterization by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and mass spectrometry (MS). The derivative of melamine was evaluated for its antioxidant activity and exhibited good DPPH and FRAP antioxidant activity. Additionally, we evaluated the putative effect of the molecule on the COX-2 enzyme through molecular dynamic simulation (MDS), and the result suggested that the TP derivative is a potential anti-inflammatory agent that can interact with the COX-2 enzyme because of the high number of protein-ligand interactions observed with MDS. Finally, the study of theoretical physicochemical properties, the observation of low toxicity (hemolysis assay), and the evaluation of oral bioavailability of the TP derivative showed that it is a possible anti-inflammatory drug candidate.

Automatic screening of antioxidants based on the evaluation of kinetics of suppression of chemiluminescence in a luminol–hydrogen peroxide system using a sequential injection analysis setup with a flow-batch detection cell

2019 ◽  
Vol 11 (19) ◽  
pp. 2531-2536
Author(s):  
Gabriela Chládková ◽  
Klára Kunovská ◽  
Petr Chocholouš ◽  
Miroslav Polášek ◽  
Hana Sklenářová
Keyword(s):  
Hydrogen Peroxide ◽  
Antioxidant Activity ◽  
Real Time ◽  
Sequential Injection Analysis ◽  
Sequential Injection ◽  
Real Time Monitoring ◽  
Detection Cell ◽  
Phenolic Substances ◽  
Kinetics Of

Real time monitoring of kinetic profiles of antioxidant activity of phenolic substances.

1167-P: Safety and Efficacy of 52 Weeks' Therapy with Hydroxychloroquine (HCQ)—First Anti-inflammatory Drug Approved in India for T2D

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1167-P
Author(s):  
ANIL PAREEK ◽  
RAVI TEJRAJ MEHTA ◽  
SHRUTI DHARMADHIKARI ◽  
KUMAR BHASKAR NAIDU
Keyword(s):  
Safety And Efficacy ◽  
Inflammatory Drug ◽  
Anti Inflammatory
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