Determination of dimetridazole and metronidazole in poultry and porcine tissues by gas chromatography–electron capture negative ionization mass spectrometry

2005 ◽  
Vol 530 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Clare Ho ◽  
Della W.M. Sin ◽  
K.M. Wong ◽  
Hubert P.O. Tang
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Electron Capture ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Electron Capture Negative Ionization ◽  
Negative Ionization ◽  
Porcine Tissues

Determination of Desaminosulfamethazine, Sulfamethazine, and N4-Acetylsulfamethazine by Gas Chromatography with Electron Capture Detection and Confirmation by Gas Chromatography-Chemical Ionization Mass Spectrometry

1987 ◽  
Vol 70 (3) ◽  
pp. 546-553
Author(s):  
Jean E Matusik ◽  
Greg C Guyer ◽  
Jaroslav N Geleta ◽  
Charlie J Barnes
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Electron Capture ◽  
Chemical Ionization ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Electron Capture Detection ◽  
Ionization Mass ◽  
Veal Calf

Abstract An electron capture gas chromatographic method for the determination of sulfamethazine was modified to separate and quantitate simultaneously sulfamethazine and 2 of its metabolites, N4-acetylsulfamethazine and desaminosulfamethazine. The modified method was applied to incurred residues in a veal calf depletion study and to incurred residues in swine tissues. With capillary column gas chromatography-positive ion chemical ionization mass spectrometry, confirmation of the identities of incurred desaminosulfamethazine, N4-acetylsulfamethazine, and sulfamethazine in tissues was obtained from a single injection.

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