scholarly journals Determination of hydroxyl radicals in advanced oxidation processes with dimethyl sulfoxide trapping and liquid chromatography

2004 ◽  
Vol 527 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Chao Tai ◽  
Jin-Feng Peng ◽  
Jing-Fu Liu ◽  
Gui-Bin Jiang ◽  
Hong Zou
Keyword(s):  
Liquid Chromatography ◽  
Dimethyl Sulfoxide ◽  
Hydroxyl Radicals ◽  
Advanced Oxidation Processes ◽  
Advanced Oxidation ◽  
Oxidation Processes

scholarly journals Degradation of Losartan in Fresh Urine by Sonochemical and Photochemical Advanced Oxidation Processes

Water ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3398 ◽  
Author(s):  
John F. Guateque-Londoño ◽  
Efraím A. Serna-Galvis ◽  
Yenny Ávila-Torres ◽  
Ricardo A. Torres-Palma
Keyword(s):  
Hydroxyl Radical ◽  
Hydroxyl Radicals ◽  
Advanced Oxidation Processes ◽  
Degradation Products ◽  
Advanced Oxidation ◽  
Fukui Function ◽  
Oxidation Processes ◽  
Theoretical Analyses ◽  
Fresh Urine

In this work, the degradation of the pharmaceutical losartan, in simulated fresh urine (which was considered because urine is the main excretion route for this compound) by sonochemistry and UVC/H2O2 individually, was studied. Initially, special attention was paid to the degrading action of the processes. Then, theoretical analyses on Fukui function indices, to determine electron-rich regions on the pharmaceutical susceptible to attacks by the hydroxyl radical, were performed. Afterward, the ability of the processes to mineralize losartan and remove the phyto-toxicity was tested. It was found that in the sonochemical treatment, hydroxyl radicals played the main degrading role. In turn, in UVC/H2O2, both the light and hydroxyl radical eliminated the target contaminant. The sonochemical system showed the lowest interference for the elimination of losartan in the fresh urine. It was established that atoms in the imidazole of the contaminant were the moieties most prone to primary transformations by radicals. This was coincident with the initial degradation products coming from the processes action. Although both processes exhibited low mineralizing ability toward losartan, the sonochemical treatment converted losartan into nonphytotoxic products. This research presents relevant results on the elimination of a representative pharmaceutical in fresh urine by two advanced oxidation processes.

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