Understanding the molecular basis of the high oxygen affinity variant human hemoglobin Coimbra

2018 ◽  
Vol 637 ◽  
pp. 73-78 ◽  
Author(s):  
S.E. Jorge ◽  
M. Bringas ◽  
A.A. Petruk ◽  
M. Arrar ◽  
M.A. Marti ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Oxygen Affinity ◽  
High Oxygen ◽  
Human Hemoglobin ◽  
High Oxygen Affinity

Hemoglobin Legnano (α2141 (HC3) Arg → Leu β2): A New Abnormal Human Hemoglobin with High Oxygen Affinity

Hemoglobin ◽  
1978 ◽  
Vol 2 (3) ◽  
pp. 249-259 ◽  
Author(s):  
F. Mavilio ◽  
M. Marinucci ◽  
L. Tentori ◽  
P. P. Fontanarosa ◽  
U. Rossi ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
High Oxygen ◽  
Human Hemoglobin ◽  
High Oxygen Affinity

scholarly journals Semihemoglobins, High Oxygen Affinity Dimeric Forms of Human Hemoglobin Respond Efficiently to Allosteric Effectors without Forming Tetramers

2004 ◽  
Vol 279 (47) ◽  
pp. 48959-48967 ◽  
Author(s):  
Antonio Tsuneshige ◽  
Kenji Kanaori ◽  
Uri Samuni ◽  
David Danstker ◽  
Joel M. Friedman ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
High Oxygen ◽  
Human Hemoglobin ◽  
Allosteric Effectors ◽  
High Oxygen Affinity

scholarly journals Hemoglobin Andrew-Minneapolis αA2β144 Lys → Asn2: A New High-Oxygen-Affinity Mutant Human Hemoglobin

Blood ◽  
1974 ◽  
Vol 44 (4) ◽  
pp. 543-549 ◽  
Author(s):  
Solomon J. Zak ◽  
Bernadine Brimhall ◽  
Richard T. Jones ◽  
Manuel E. Kaplan
Keyword(s):  
Functional Properties ◽  
Primary Structure ◽  
Whole Blood ◽  
Autosomal Dominant ◽  
Oxygen Affinity ◽  
High Oxygen ◽  
Human Hemoglobin ◽  
High Oxygen Affinity ◽  
Dominant Characteristic ◽  
Β Chain

Abstract The functional properties and primary structure of a new β-chain mutant of human hemoglobin are described. The mutant was transmitted as an autosomal dominant characteristic. Affected members of the kindred exhibited marked erythrocytosis due to the high oxygen affinity of the resultant hemoglobin. The abnormality is associated with a substitution of an asparaginyl residue for lysine in the 144 position of the β-chain, αA2β144Lys→Asn2, presumably due to an AAA/G to AAA/U transversion. The mutant hemoglobin displayed a profound increase in oxygen affinity, with a P50 of the fresh whole blood of 14 mm Hg. The isolated mutant hemoglobin exhibited near normal heme—heme interaction, a half-normal Bohr effect, and normal reactivity with 2,3-diphosphoglycerate.

Hemoglobin fort gordon or α2β2145 Tyr → Asp, a new high-oxygen-affinity hemoglobin variant

1975 ◽  
Vol 400 (2) ◽  
pp. 343-347 ◽  
Author(s):  
H.B. Kleckner ◽  
J.B. Wilson ◽  
J.G. Lindeman ◽  
P.D. Stevens ◽  
G. Niazi ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
High Oxygen ◽  
Hemoglobin Variant ◽  
High Oxygen Affinity

Germline mosaicism for an alanine to valine substitution at residue ? 140 in hemoglobin Puttelange, a new variant with high oxygen affinity

1995 ◽  
Vol 96 (6) ◽  
pp. 711-716 ◽  
Author(s):  
H. Wajcman ◽  
E. Girodon ◽  
D. Prom� ◽  
M.L. North ◽  
F. Plassa ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
High Oxygen ◽  
Germline Mosaicism ◽  
New Variant ◽  
High Oxygen Affinity

Unusual finding of high oxygen affinity haemoglobinopathy treated with phlebotomy: a rare but predictable union

2021 ◽  
pp. 103290
Author(s):  
Epifania Rita Testa ◽  
Adriana Masotti ◽  
Patrizia Valeri ◽  
Luciana Geremia ◽  
Valeria Brunetta ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
High Oxygen ◽  
High Oxygen Affinity ◽  
Unusual Finding

scholarly journals Haemoglobin Olympia {β Codon 20 (B2) G→A, Val→Met}: A Silent Haemoglobin Variant

2021 ◽  
Author(s):  
Abhay A Bhave ◽  
Lakshmi Iyer ◽  
Nawal Kazi ◽  
Manju Gorivale ◽  
Anita Nadkarni
Keyword(s):  
High Performance ◽  
Extended Family ◽  
Globin Gene ◽  
Oxygen Affinity ◽  
High Oxygen ◽  
Cerebral Vessel ◽  
Haemoglobin Variant ◽  
First Case ◽  
History Of ◽  
High Oxygen Affinity

High oxygen affinity haemoglobin variants are rare and often underdiagnosed in persistent erythrocytosis with no apparent aetiology. Here the author present a 29-year-old Indian male patient with a long-standing history of erythrocytosis which was incidentally detected. The proband had a prothrombotic family history of cerebral vessel stroke in his paternal grandfather at a young age and unexplained erythrocytosis in his father and brother. A review of his haemograms showed persistent high haemoglobin values. Routine tests did not reveal any specific aetiology and haemoglobin electrophoresis by High-Performance Liquid Chromatography (HPLC) showed absence of any abnormal peak or unstable haemoglobin. DNA sequencing of the β globin gene revealed heterozygosity for codon 20 {GTG→ATG, Valine (Val)→ Methionine (Met)} mutation confirming the presence of an electrophoretically silent Hb variant - Haemoglobin Olympia in him and his extended family members. This case study emphasises importance of this rare entity of high oxygen affinity haemoglobin variant as a differential diagnosis while screening for erythrocytosis. This is the first case report of Haemoglobin Olympia from India reported in the literature.

scholarly journals A Newly Characterized Hemoglobin Variant with a High Oxygen Affinity, Hb Fuchu-II, Presenting with Acute Myocardial Infarction

2016 ◽  
Vol 55 (3) ◽  
pp. 285-287
Author(s):  
Raku Son ◽  
Takakazu Higuchi ◽  
Atsushi Mizuno ◽  
Ryosuke Koyamada ◽  
Sadamu Okada ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Oxygen Affinity ◽  
High Oxygen ◽  
Hemoglobin Variant ◽  
High Oxygen Affinity
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