scholarly journals A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules

2016 ◽  
Vol 596 ◽  
pp. 22-42 ◽  
Author(s):  
Sheila M. Barros ◽  
Susan K. Whitaker ◽  
Pinakin Sukthankar ◽  
L. Adriana Avila ◽  
Sushanth Gudlur ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Amphipathic Peptide ◽  
Peptide Capsules

Branched Amphipathic Peptide Capsules: Different Ratios of the Two Constituent Peptides Direct Distinct Bilayer Structures, Sizes, and DNA Transfection Efficiency

Langmuir ◽  
2017 ◽  
Vol 33 (28) ◽  
pp. 7096-7104 ◽  
Author(s):  
Sheila de M. Barros ◽  
L. Adriana Avila ◽  
Susan K. Whitaker ◽  
Kayla E. Wilkinson ◽  
Pinakin Sukthankar ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Dna Transfection ◽  
Amphipathic Peptide ◽  
Peptide Capsules

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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