Advanced glycation end products induced immune maturation of dendritic cells controls heart failure through NF-κB signaling pathway

2015 ◽  
Vol 580 ◽  
pp. 112-120 ◽  
Author(s):  
Weiwei Cao ◽  
Jianwen Chen ◽  
Yanfang Chen ◽  
Shaorui Chen ◽  
Xi Chen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dendritic Cells ◽  
Signaling Pathway ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Immune Maturation

scholarly journals Association study of polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with susceptibility and prognosis of heart failure

Gene ◽  
2012 ◽  
Vol 510 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Carolina Rodrigues Cohen ◽  
Vanessa Backes Nascimento Diel ◽  
Vanessa Laubert La Porta ◽  
Luís Eduardo Rohde ◽  
Andréia Biolo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Association Study ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway

FEBS Letters ◽  
2009 ◽  
Vol 584 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Akiko Hirose ◽  
Takahisa Tanikawa ◽  
Hiroko Mori ◽  
Yosuke Okada ◽  
Yoshiya Tanaka
Keyword(s):  
Signaling Pathway ◽  
Advanced Glycation End Products ◽  
Endothelial Permeability ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Chronic exercise training prevents coronary artery stiffening in aortic-banded miniswine: role of perivascular adipose-derived advanced glycation end products

2019 ◽  
Vol 127 (3) ◽  
pp. 816-827 ◽  
Author(s):  
An Ouyang ◽  
T. Dylan Olver ◽  
Craig A. Emter ◽  
Bradley S. Fleenor
Keyword(s):  
Heart Failure ◽  
Coronary Artery ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Interval Exercise ◽  
Glycation End Products ◽  
End Products ◽  
Artery Stiffness

Heart failure (HF) is associated with increased large conduit artery stiffness and afterload resulting in stiffening of the coronary arteries. Perivascular adipose tissue (PVAT) and advanced glycation end products (AGE) both promote arterial stiffness, yet the mechanisms by which coronary PVAT promotes arterial stiffness and the efficacy of exercise to prevent coronary stiffness are unknown. We hypothesized that both chronic continuous and interval exercise training would prevent coronary PVAT-mediated AGE secretion and arterial stiffness. Yucatan miniature swine were divided into four groups: control-sedentary (CON), aortic banded sedentary-heart failure (HF), aortic banded HF-continuous exercise trained (HF+CONT), and aortic banded HF-interval exercise trained (HF+IT). The left circumflex and right coronary arteries underwent ex vivo mechanical testing, and arterial AGE, elastin, and collagen were assessed. Coronary elastin elastic modulus (EEM) and elastin protein were lower and AGE was increased with HF compared with CON, which was prevented by both HF+CONT and HF+IT. Mouse aortic segments treated with swine coronary PVAT conditioned medium had lower EEM and elastin content and greater AGE secretion and arterial AGE accumulation in HF compared with CON, which was prevented by both HF+CONT and HF+IT. Aminoguanidine (AMG), an AGE inhibitor, prevented the reduction in EEM, arterial elastin content, and AGE accumulation in mouse aortic segments treated with PVAT conditioned medium in the HF group. Our data demonstrate efficacy for chronic continuous and interval exercise to prevent coronary artery stiffness via inhibition of PVAT-derived AGE secretion in a preclinical miniswine model of pressure overload-induced HF. NEW & NOTEWORTHY Our findings show that chronic continuous and interval exercise training regimens prevent coronary artery stiffness associated with inhibition of perivascular adipose tissue-derived advanced glycation end products in a translational pressure overload-induced heart failure model potentially providing an effective therapeutic option for heart failure patients.

Relation of Soluble Receptor for Advanced Glycation End Products to Predict Mortality in Patients With Chronic Heart Failure Independently of Seattle Heart Failure Score

2011 ◽  
Vol 107 (6) ◽  
pp. 938-944 ◽  
Author(s):  
Sergio Raposeiras-Roubín ◽  
Bruno K. Rodiño-Janeiro ◽  
Lilian Grigorian-Shamagian ◽  
María Moure-González ◽  
Ana Seoane-Blanco ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Advanced Glycation End Products ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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