Expression of organic osmolyte transporters in cultured rat astrocytes and rat and human cerebral cortex

2014 ◽  
Vol 560 ◽  
pp. 59-72 ◽  
Author(s):  
Jessica Oenarto ◽  
Boris Görg ◽  
Michael Moos ◽  
Hans-Jürgen Bidmon ◽  
Dieter Häussinger
Keyword(s):  
Cerebral Cortex ◽  
Human Cerebral Cortex ◽  
Organic Osmolyte ◽  
Rat Astrocytes

Ephrin/Ephrin Receptor Expression in Ammonia-Treated Rat Astrocytes and in Human Cerebral Cortex in Hepatic Encephalopathy

2014 ◽  
Vol 40 (2) ◽  
pp. 274-283 ◽  
Author(s):  
Karmela Sobczyk ◽  
Markus S. Jördens ◽  
Ayse Karababa ◽  
Boris Görg ◽  
Dieter Häussinger
Keyword(s):  
Cerebral Cortex ◽  
Hepatic Encephalopathy ◽  
Receptor Expression ◽  
Human Cerebral Cortex ◽  
Ephrin Receptor ◽  
Rat Astrocytes

Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy

Glia ◽  
2014 ◽  
Vol 63 (1) ◽  
pp. 37-50 ◽  
Author(s):  
Boris Görg ◽  
Ayse Karababa ◽  
Aygul Shafigullina ◽  
Hans J. Bidmon ◽  
Dieter Häussinger
Keyword(s):  
Cerebral Cortex ◽  
Hepatic Encephalopathy ◽  
Human Cerebral Cortex ◽  
Rat Astrocytes

C-fos, ERK1/2, MAP2, NOTCH1 Proteins Expression Patterns in Human Cerebral Cortex Neurons after Ischemic Stroke

2020 ◽  
Vol 75 (3) ◽  
pp. 226-233
Author(s):  
Svetlana P. Sergeeva ◽  
Aleksey V. Lyundup ◽  
Valery V. Beregovykh ◽  
Petr F. Litvitskiy ◽  
Aleksey A. Savin ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Ischemic Stroke ◽  
Expression Patterns ◽  
Immunohistochemical Method ◽  
Left Middle Cerebral Artery ◽  
Contralateral Hemisphere ◽  
Human Cerebral Cortex ◽  
Fos Protein ◽  
Urgent Task ◽  
Indirect Immunoperoxidase

Background. The search for protein (these include c-fos, ERK1/2, MAP2, NOTCH1) expression that provide neuroplasticity mechanisms of the cerebral cortex after ischemic stroke (IS) patterns is an urgent task. Aims to reveal c-fos, ERK1/2, MAP2, NOTCH1 proteins expression patterns in human cerebral cortex neurons after IS. Materials and methods. We studied 9 left middle cerebral artery (LMCA) IS patients cerebral cortex samples from 3 zones: 1 the zone adjacent to the necrotic tissue focus; 2 zone remote from the previous one by 47 cm; 3 zone of the contralateral hemisphere, symmetric to the IS focus. Control samples were obtained from 3 accident died people. Identification of targeted proteins NSE, c-fos, ERK1/2, MAP2, NOTCH1 was performed by indirect immunoperoxidase immunohistochemical method. Results. Moving away from the ischemic focus, there is an increase in the density of neurons and a decrease in the damaged neurons proportion, the largest share of c-fos protein positive neurons in zone 2, NOTCH1 positive neurons in zone 1, smaller fractions of ERK1/2 and MAP2 positive neurons compared to the control only in samples of zone 1. Conclusions. With the IS development, the contralateral hemisphere is intact tissue increased activation zone, while the zones 1 and 2 have pathological activation signs. In zone 1 of the range, the adaptive response of the tissue decreases, and in zone 2 it expands. Therefore, a key target for therapeutic intervention is zone 2.

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