Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice

2014 ◽  
Vol 552-553 ◽  
pp. 100-107 ◽  
Author(s):  
Carlos Hidalgo ◽  
Chandra Saripalli ◽  
Henk L. Granzier
Keyword(s):  
Transcriptional Regulation ◽  
Exercise Training ◽  
Striated Muscle ◽  
Wild Type ◽  
Post Transcriptional Regulation

scholarly journals Application of Domain- and Genotype-Specific Models to Infer Post-Transcriptional Regulation of Segmentation Gene Expression in Drosophila

Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1232
Author(s):  
Maria A. Duk ◽  
Vitaly V. Gursky ◽  
Maria G. Samsonova ◽  
Svetlana Yu. Surkova
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Protein Expression ◽  
Drosophila Embryo ◽  
Synthesis Rate ◽  
Protein Synthesis Rate ◽  
Wild Type ◽  
Segmentation Gene ◽  
Segmentation Gene Expression ◽  
Post Transcriptional Regulation

Unlike transcriptional regulation, the post-transcriptional mechanisms underlying zygotic segmentation gene expression in early Drosophila embryo have been insufficiently investigated. Condition-specific post-transcriptional regulation plays an important role in the development of many organisms. Our recent study revealed the domain- and genotype-specific differences between mRNA and the protein expression of Drosophila hb, gt, and eve genes in cleavage cycle 14A. Here, we use this dataset and the dynamic mathematical model to recapitulate protein expression from the corresponding mRNA patterns. The condition-specific nonuniformity in parameter values is further interpreted in terms of possible post-transcriptional modifications. For hb expression in wild-type embryos, our results predict the position-specific differences in protein production. The protein synthesis rate parameter is significantly higher in hb anterior domain compared to the posterior domain. The parameter sets describing Gt protein dynamics in wild-type embryos and Kr mutants are genotype-specific. The spatial discrepancy between gt mRNA and protein posterior expression in Kr mutants is well reproduced by the whole axis model, thus rejecting the involvement of post-transcriptional mechanisms. Our models fail to describe the full dynamics of eve expression, presumably due to its complex shape and the variable time delays between mRNA and protein patterns, which likely require a more complex model. Overall, our modeling approach enables the prediction of regulatory scenarios underlying the condition-specific differences between mRNA and protein expression in early embryo.

scholarly journals miR-206 Enforces a Slow Muscle Phenotype

2019 ◽  
Author(s):  
Kristen K. Bjorkman ◽  
Martin G. Guess ◽  
Brooke C. Harrison ◽  
Michael M. Polmear ◽  
Angela K. Peter ◽  
...  
Keyword(s):  
Striated Muscle ◽  
Systolic Dysfunction ◽  
Slow Muscle ◽  
Functional Adaptation ◽  
Muscle Fiber Types ◽  
Fiber Types ◽  
Wild Type ◽  
Sexual Dimorphisms ◽  
Male Specific ◽  
Post Transcriptional Regulation

AbstractStriated muscle is a highly specialized collection of tissues with contractile properties varying according to functional needs. Although muscle fiber types are established postnatally, lifelong plasticity facilitates stimulus-dependent adaptation. Functional adaptation requires molecular adaptation, partially provided by miRNA-mediated post-transcriptional regulation. miR-206 is a muscle-specific miRNA enriched in slow muscles. We investigated whether miR-206 drives the slow muscle phenotype or is merely an outcome. We found that miR-206 expression increases in both physiologic (including female sex and endurance exercise) and pathologic conditions that promote a slow phenotype. Consistent with that observation, the slow soleus muscle of male miR-206 knockout mice displays a faster phenotype than wild-type mice. Moreover, their left ventricles have a faster myosin profile accompanied by male-specific dilation and systolic dysfunction. Thus, miR-206 appears necessary to enforce a slow skeletal and cardiac muscle phenotype and to play a key role in muscle sexual dimorphisms.

43-OR: Post-transcriptional Regulation of Slc16a1 mRNA Is Essential for Maintaining Normal ß-Cell Function

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 43-OR
Author(s):  
DINA MOSTAFA ◽  
AKINORI TAKAHASHI ◽  
TADASHI YAMAMOTO
Keyword(s):  
Transcriptional Regulation ◽  
Cell Function ◽  
Post Transcriptional Regulation

scholarly journals Transcriptional and post-transcriptional regulation of κB-controlled genes by pp60v-src

Oncogene ◽  
1997 ◽  
Vol 15 (1) ◽  
pp. 29-43 ◽  
Author(s):  
Eric Cabannes ◽  
Marie-France Vives ◽  
Pierre-André Bédard
Keyword(s):  
Transcriptional Regulation ◽  
Post Transcriptional Regulation
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