scholarly journals Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23)

2011 ◽  
Vol 512 (2) ◽  
pp. 143-153 ◽  
Author(s):  
José E.S. Nunes ◽  
Rodrigo G. Ducati ◽  
Ardala Breda ◽  
Leonardo A. Rosado ◽  
Bibiana M. de Souza ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Histidinol Dehydrogenase

scholarly journals Cardamom Derived Phytochemicals against Mycobacterium tuberculosis Causing Tuberculosis

2020 ◽  
pp. 132-135
Author(s):  
Bijan Pumar Patra ◽  
Bapujee Palai ◽  
Sarthak Siddhant Mishra ◽  
Sunil Jha ◽  
Dipankar Bhattacharyay
Keyword(s):  
Acetic Acid ◽  
Mycobacterium Tuberculosis ◽  
Molecular Docking ◽  
Life Cycle ◽  
Pathogenic Bacteria ◽  
Discovery Studio ◽  
Docking Method ◽  
Severe Infections ◽  
Histidinol Dehydrogenase ◽  
Molecular Docking Method

Tuberculosis is a disease caused by severe infections by Mycobacterium tuberculosis, a pathogenic bacteria. These bacteria cause infections in humans and thus lead to an unhealthy life. Phytochemicals from cardamom plant extract are traditionally used to cure Tuberculosis. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that acetic acid can effectively deactivate histidinol dehydrogenase (H37Rv) thereby interrupting the life cycle of the organism.

Mycobacterium tuberculosis histidinol dehydrogenase: biochemical characterization and inhibition studies

RSC Advances ◽  
2016 ◽  
Vol 6 (34) ◽  
pp. 28406-28418 ◽  
Author(s):  
Juleane Lunardi ◽  
Leonardo Kras Borges Martinelli ◽  
Alessandra Silva Raupp ◽  
José Eduardo Sacconi Nunes ◽  
Diana Carolina Rostirolla ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biochemical Characterization ◽  
Biochemical Studies ◽  
Histidinol Dehydrogenase ◽  
Inhibition Studies

We describe a series of biochemical studies on recombinantMycobacterium tuberculosisHisD (MtHisD) and the synthesis of a series of compounds which are, to the best of our knowledge, the first inhibitors ofMtHisD activity reported in the literature.

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