Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic β-cell glucose-sensing, cellular signal transduction and integrity

2007 ◽  
Vol 461 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Steven Patterson ◽  
Peter R. Flatt ◽  
Neville H. McClenaghan
Keyword(s):  
Signal Transduction ◽  
Glucose Sensing ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Homocysteine Thiolactone ◽  
Cellular Signal Transduction ◽  
Cellular Signal ◽  
Cell Glucose

Lactate overrides central nervous but not β-cell glucose sensing in humans

2008 ◽  
Vol 116 (09) ◽  
Author(s):  
SM Schmid ◽  
M Hallschmid ◽  
K Jauch-Chara ◽  
KM Oltmanns ◽  
A Peters ◽  
...  
Keyword(s):  
Glucose Sensing ◽  
Β Cell ◽  
Cell Glucose

INCRETIN AND DIABETES

2011 ◽  
pp. 5-10
Author(s):  
Huu Dang Tran
Keyword(s):  
Type 2 Diabetes ◽  
Cell Proliferation ◽  
Glycaemic Control ◽  
Animal Studies ◽  
Dipeptidyl Peptidase ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Glucose Sensitivity ◽  
Cell Glucose

The incretins are peptide hormones secreted from the gut in response to food. They increase the secretion of insulin. The incretin response is reduced in patients with type 2 diabetes so drugs acting on incretins may improve glycaemic control. Incretins are metabolised by dipeptidyl peptidase, so selectively inhibiting this enzyme increases the concentration of circulating incretins. A similar effect results from giving an incretin analogue that cannot be cleaved by dipeptidyl peptidase. Studies have identified other actions including improvement in pancreatic β cell glucose sensitivity and, in animal studies, promotion of pancreatic β cell proliferation and reduction in β cell apoptosis.

scholarly journals Mechanisms of glucose sensing in the pancreatic β-cell

Islets ◽  
2011 ◽  
Vol 3 (5) ◽  
pp. 224-230 ◽  
Author(s):  
Leonid E. Fridlyand ◽  
Louis H. Phillipson
Keyword(s):  
Glucose Sensing ◽  
Pancreatic Β Cell ◽  
Β Cell
Sign in / Sign up

Export Citation Format

Share Document