Ca2+- and voltage-dependent inactivation of the expressed L-type Cav1.2 calcium channel

2005 ◽  
Vol 437 (1) ◽  
pp. 42-50 ◽  
Author(s):  
L’. Lacinová ◽  
F. Hofmann
Keyword(s):  
Calcium Channel ◽  
Dependent Inactivation ◽  
Voltage Dependent

scholarly journals Disruption of the IS6-AID Linker Affects Voltage-gated Calcium Channel Inactivation and Facilitation

2009 ◽  
Vol 133 (3) ◽  
pp. 327-343 ◽  
Author(s):  
Felix Findeisen ◽  
Daniel L. Minor
Keyword(s):  
Calcium Channel ◽  
Common Mechanism ◽  
Interaction Domain ◽  
Voltage Gated ◽  
Calcium Dependent ◽  
Calcium Channel Inactivation ◽  
Dependent Inactivation ◽  
Voltage Dependent ◽  
Rigid Connection ◽  
Voltage Gated Calcium Channel

Two processes dominate voltage-gated calcium channel (CaV) inactivation: voltage-dependent inactivation (VDI) and calcium-dependent inactivation (CDI). The CaVβ/CaVα1-I-II loop and Ca2+/calmodulin (CaM)/CaVα1–C-terminal tail complexes have been shown to modulate each, respectively. Nevertheless, how each complex couples to the pore and whether each affects inactivation independently have remained unresolved. Here, we demonstrate that the IS6–α-interaction domain (AID) linker provides a rigid connection between the pore and CaVβ/I-II loop complex by showing that IS6-AID linker polyglycine mutations accelerate CaV1.2 (L-type) and CaV2.1 (P/Q-type) VDI. Remarkably, mutations that either break the rigid IS6-AID linker connection or disrupt CaVβ/I-II association sharply decelerate CDI and reduce a second Ca2+/CaM/CaVα1–C-terminal–mediated process known as calcium-dependent facilitation. Collectively, the data strongly suggest that components traditionally associated solely with VDI, CaVβ and the IS6-AID linker, are essential for calcium-dependent modulation, and that both CaVβ-dependent and CaM-dependent components couple to the pore by a common mechanism requiring CaVβ and an intact IS6-AID linker.

scholarly journals Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins

2006 ◽  
Vol 454 (1) ◽  
pp. 115-129 ◽  
Author(s):  
Norbert Weiss ◽  
Abir Tadmouri ◽  
Mohamad Mikati ◽  
Michel Ronjat ◽  
Michel De Waard
Keyword(s):  
Calcium Channel ◽  
G Proteins ◽  
Channel Regulation ◽  
Dependent Inactivation ◽  
Voltage Dependent ◽  
Calcium Channel Regulation

A simulation study of voltage-dependent inactivation in the cardiac L-type calcium channel

2007 ◽  
Vol 42 (6) ◽  
pp. S20
Author(s):  
Yoshihisa Kurachi ◽  
Shingo Suzuki ◽  
Shingo Murakami ◽  
Ian Findlay
Keyword(s):  
Calcium Channel ◽  
Simulation Study ◽  
Dependent Inactivation ◽  
Voltage Dependent

scholarly journals Voltage-dependent inactivation in a cardiac-skeletal chimeric calcium channel

FEBS Letters ◽  
1995 ◽  
Vol 360 (2) ◽  
pp. 144-150 ◽  
Author(s):  
L Parent ◽  
M Gopalakrishnan ◽  
A.E Lacerda ◽  
X Wei ◽  
E Perez-Reyes
Keyword(s):  
Calcium Channel ◽  
Dependent Inactivation ◽  
Voltage Dependent
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