cDNA sequence, 5′-flanking region, and promoter activity of the Neotomodon alstoni alstoni Clara cell secretory protein gene

2004 ◽  
Vol 427 (2) ◽  
pp. 170-179 ◽  
Author(s):  
Héctor Macı́as ◽  
Ana Marı́a Pasapera ◽  
Marco Allán Pérez-Solis ◽  
Alfredo Ulloa-Aguirre ◽  
Rubén Gutiérrez-Sagal
Keyword(s):  
Promoter Activity ◽  
Cdna Sequence ◽  
Protein Gene ◽  
Secretory Protein ◽  
Clara Cell ◽  
Clara Cell Secretory Protein ◽  
Flanking Region

Structure and Regulation of the Murine Clara Cell Secretory Protein Gene

Genomics ◽  
1994 ◽  
Vol 20 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Barry R. Stripp ◽  
Jacquelyn A. Huffman ◽  
Robert J. Bohinski
Keyword(s):  
Protein Gene ◽  
Secretory Protein ◽  
Clara Cell ◽  
Clara Cell Secretory Protein

C/EBP α and C/EBP δ Activate the Clara Cell Secretory Protein Gene through Interaction with Two Adjacent C/EBP-Binding Sites

2000 ◽  
Vol 22 (4) ◽  
pp. 469-480 ◽  
Author(s):  
Tobias N. Cassel ◽  
Lena Nordlund-Möller ◽  
Olof Andersson ◽  
Jan-Åke Gustafsson ◽  
Magnus Nord
Keyword(s):  
Binding Sites ◽  
Protein Gene ◽  
Secretory Protein ◽  
Clara Cell ◽  
Clara Cell Secretory Protein

Multiple mechanisms for oxygen‐induced regulation of the Clara cell secretory protein gene

2003 ◽  
Vol 17 (14) ◽  
pp. 1-22 ◽  
Author(s):  
Patricia L. Ramsay ◽  
Ziqiang Luo ◽  
Angela Major ◽  
Moon S. Park ◽  
Milton Finegold ◽  
...  
Keyword(s):  
Protein Gene ◽  
Secretory Protein ◽  
Clara Cell ◽  
Clara Cell Secretory Protein

Regulation of Clara cell secretory protein gene expression by the CCAAT-binding factor NF-Y

2007 ◽  
Vol 459 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Adriana Acosta ◽  
Teresa Zariñán ◽  
Héctor Macías ◽  
Ana María Pasapera ◽  
Marco Allán Pérez-Solis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Gene ◽  
Secretory Protein ◽  
Clara Cell ◽  
Clara Cell Secretory Protein ◽  
Binding Factor

The Expression of Clara Cell Secretory Protein in BAL Fluid of Patients with Idiopathic Interstitial Pneumonia

2002 ◽  
Vol 53 (2) ◽  
pp. 127
Author(s):  
Sang Won Um ◽  
Seon Jin Han ◽  
Chang Min Choi ◽  
Chang Hoon Lee ◽  
Chul Gyu Yoo ◽  
...  
Keyword(s):  
Interstitial Pneumonia ◽  
Secretory Protein ◽  
Idiopathic Interstitial Pneumonia ◽  
Clara Cell ◽  
Clara Cell Secretory Protein

IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway

2002 ◽  
Vol 283 (1) ◽  
pp. L67-L75 ◽  
Author(s):  
Suil Kim ◽  
Jae Jeong Shim ◽  
Pierre-Regis Burgel ◽  
Iris F. Ueki ◽  
Trang Dao-Pick ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Expression ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Growth Factor Receptor ◽  
Secretory Protein ◽  
Clara Cell ◽  
Clara Cell Secretory Protein ◽  
Gene And Protein Expression

Previous work showed that the Th2 cytokine interleukin (IL)-13 induces goblet cell metaplasia via an indirect mechanism involving the expression and subsequent activation of epidermal growth factor receptor (EGFR). Because Clara cell secretory protein (CCSP) expression has been reported in cells that express mucins, we examined the effect of IL-13 on CCSP gene and protein expression in pathogen-free rat airways and in pulmonary mucoepidermoid NCI-H292 cells. Intratracheal instillation of IL-13 induced CCSP mRNA in epithelial cells without cilia within 8–16 h, maximal between 24 and 48 h; CCSP immunostaining increased in a time-dependent fashion, maximal at 48 h. The CCSP immunostaining was localized in nongranulated secretory cells and goblet cells and in the lumen. Pretreatment with the selective EGFR tyrosine kinase inhibitor BIBX1522, cyclophosphamide (an inhibitor of bone marrow leukocyte mobilization), or a blocking antibody to IL-8 prevented CCSP staining. Treatment of NCI-H292 cells with the EGFR ligand transforming growth factor-α, but not with IL-13 alone, induced CCSP gene and protein expression. Selective EGFR tyrosine kinase inhibitors, BIBX1522 and AG1478, prevented CCSP expression in NCI-H292 cells, but the platelet-derived growth factor receptor tyrosine kinase inhibitor AG1295 had no effect. These findings indicate that IL-13 induces CCSP expression via an EGFR- and leukocyte-dependent pathway.

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