Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders

2003 ◽  
Vol 419 (1) ◽  
pp. 80-88 ◽  
Author(s):  
Barry I Hudson ◽  
Loredana G Bucciarelli ◽  
Thoralf Wendt ◽  
Taichi Sakaguchi ◽  
Evanthia Lalla ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Therapeutic Intervention ◽  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Inflammatory Disorders ◽  
Glycation Endproducts

scholarly journals A karbonilstressz szerepe a diabetes szövődményeinek kialakulásában

2019 ◽  
Vol 160 (40) ◽  
pp. 1567-1573 ◽  
Author(s):  
Kinga Makk-Merczel ◽  
András Szarka
Keyword(s):  
Diabetic Complications ◽  
Clinical Studies ◽  
Advanced Glycation Endproducts ◽  
Hydroxyl Group ◽  
Carbonyl Stress ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Oxidative Generation

Abstract: The relationship between the potentially developing complications of the 451 million people affected by diabetes and hyperglycaemia can be based on the enhanced generation of advanced glycation endproducts and the more intensive oxidative and carbonyl stress. Advanced glycation endproducts generated partly due to carbonyl stress play an important role in the pathogenesis of diabetic complications such as elevated arterial thickness, vascular permeability, enhanced angiogenesis or the more rigid vessels induced nephropathy, neuropathy, retinopathy. Furthermore, the elevated thrombocyte aggregation, the reduced fibrinolysis induced elevated coagulation, and the atherosclerosis or the mitochondrial dysfunction are important as well. The most potent target of both the non-oxidative and oxidative generation of advanced glycation endproducts can be the scavenging of α,β-unsaturated aldehydes. Although, aminoguanidine, the prototype of scavenger molecules, showed protection in different animal models, it failed in the human clinical studies. Finally, the clinical studies were terminated almost 20 years ago. The endogen dipeptide L-carnosine was also expected to mitigate the complications due to carbonyl stress. However, its clinical significance was limited by the serum carnosinases and by the consequent low serum stability and bioavailability. The carnosinase resistance of the molecule can be achieved by the change of the carboxyl group of the molecule to hydroxyl group. At the same time, the biosafety and the carbonyl stress scavenging activity of the molecule could be preserved. Although clinical studies could not be performed in the last six months, on the basis of the in vitro and in vivo results, carnosinole seems to be a promising compound to mitigate and prevent the diabetic complications. Thus it is worth to the attention of the clinicians. Orv Hetil. 2019; 160(40): 1567–1573.

Inhibition of non-enzymatic glycation by capsaicin: Targeting AGEs induced diabetic complications

2021 ◽  
Author(s):  
Ping Xu ◽  
Xiaodong Yang ◽  
Yu Wang
Keyword(s):  
Diabetic Complications ◽  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Heterogenous Group

The end product of non-enzymatic glycation is termed as advanced glycation endproducts i.e., AGEs, which are diverse heterogenous group of compounds. The highly reactive nature of AGEs makes them one...

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