Microbial flow cytometry: An ideal tool for prospective antimicrobial drug development

2016 ◽  
Vol 509 ◽  
pp. 89-91 ◽  
Author(s):  
Pushpanathan Muthirulan ◽  
Arun Richard Chandrasekaran
Keyword(s):  
Flow Cytometry ◽  
Drug Development ◽  
Antimicrobial Drug ◽  
Ideal Tool

Application of Flow Cytometry in Drug Development

2008 ◽  
pp. 141-159 ◽  
Author(s):  
Padma Narayanan ◽  
Renold J. Capocasale ◽  
Nianyu Li ◽  
Peter J. Bugelski
Keyword(s):  
Flow Cytometry ◽  
Drug Development

scholarly journals Implementation of a Market Entry Reward within the United States

2018 ◽  
Vol 46 (S1) ◽  
pp. 50-58 ◽  
Author(s):  
Gregory W. Daniel ◽  
Monika Schneider ◽  
Marianne Hamilton Lopez ◽  
Mark B. McClellan
Keyword(s):  
United States ◽  
Health Policy ◽  
Drug Development ◽  
Market Entry ◽  
The United States ◽  
Antimicrobial Drug ◽  
Multifactorial Approach

As part of a multifactorial approach to address weak incentives for innovative antimicrobial drug development, market entry rewards (MERs) are an emerging solution. Recently, the Duke-Margolis Center for Health Policy released the Priority Antimicrobial Value and Entry (PAVE) Award proposal, which combines a MER with payment reforms, transitioning from volume-based to “value-based” payments for antimicrobials. Here, the PAVE Award and similar MERs are reviewed, focusing on further refinement and avenues for implementation.

Critical reagents in flow cytometry, instrumentation and application in drug discovery development

Bioanalysis ◽  
2021 ◽  
Author(s):  
Vellalore N Kakkanaiah ◽  
Katie Matys ◽  
Patrick Bennett
Keyword(s):  
Flow Cytometry ◽  
Drug Discovery ◽  
Drug Development ◽  
Ligand Binding ◽  
Specific Interaction ◽  
Flow Cytometer ◽  
Analysis Tool ◽  
Binding Assays ◽  
Cellular Analysis ◽  
Main Components

Flow cytometer is a powerful cellular analysis tool consists of three main components; fluidics, optics and electronics. Flow cytometry methods have been used in all stages of drug development as like ligand binding assays (LBA). Both LBA and flow cytometry methods require specific interaction between the critical reagents and the analytes. Antibodies and their conjugates, viable dyes and permeabilizing buffer are the main critical reagents in flow cytometry methods. Similarly, antibodies, engineered proteins and their conjugates are the main critical reagents in LBA. The main difference between the two methods is the lack of true reference standards for flow cytometry cellular analysis.

scholarly journals Trends in Antimicrobial Drug Development: Implications for the Future

2004 ◽  
Vol 38 (9) ◽  
pp. 1279-1286 ◽  
Author(s):  
B. Spellberg ◽  
J. H. Powers ◽  
E. P. Brass ◽  
L. G. Miller ◽  
J. E. Edwards
Keyword(s):  
Drug Development ◽  
Antimicrobial Drug ◽  
The Future
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