scholarly journals In vitro release of organophosphorus acid anhydrolase from functionalized mesoporous silica against nerve agents

2012 ◽  
Vol 421 (2) ◽  
pp. 477-481 ◽  
Author(s):  
Baowei Chen ◽  
Saumil S. Shah ◽  
Yongsoon Shin ◽  
Chenghong Lei ◽  
Jun Liu
Keyword(s):  
Mesoporous Silica ◽  
In Vitro Release ◽  
Nerve Agents ◽  
Functionalized Mesoporous Silica ◽  
Organophosphorus Acid Anhydrolase ◽  
Vitro Release

scholarly journals Indometacin loading and in vitro release properties from novel carbopol coated spherical mesoporous silica nanoparticles

2013 ◽  
Vol 171 ◽  
pp. 131-138 ◽  
Author(s):  
Borislav Tzankov ◽  
Krassimira Yoncheva ◽  
Margarita Popova ◽  
Agnes Szegedi ◽  
Georgi Momekov ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
In Vitro Release ◽  
Vitro Release

Drug Loaded Porous Hydroxyapatite and Its In Vitro Release

2005 ◽  
Vol 284-286 ◽  
pp. 423-426 ◽  
Author(s):  
Y. Kim ◽  
B.G. Song ◽  
Soo Ryong Kim ◽  
Kwang Jin Kim
Keyword(s):  
Mesoporous Silica ◽  
Body Fluid ◽  
Sol Gel ◽  
In Vitro Release ◽  
Controlled Drug Delivery ◽  
Porous Hydroxyapatite ◽  
Sol Gel Process ◽  
The Matrix ◽  
Vitro Release

Porous hydroxyapatite coated with mesoporous silica has been utilized as the matrix for controlled drug delivery. TEM observation confirms the pore size of mesoporous silica scatters about 50 Å. Porous hydroxyapatite was coated with mesoporous silica via sol-gel process. Ibuprofen and was loaded into the pores of mesoporous silica, and controlled release profiles were studied by soaking the samples in a simulated body fluid using a UV-VIS spectrophotometer.

scholarly journals pH Responsive in Vitro Cargo Release of PEG Coated MSNs Is Governed by Buffer Composition

2020 ◽  
Author(s):  
Nidhi Sapre ◽  
Gaurav Das ◽  
Sneha Bajpe
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Standard Procedure ◽  
In Vitro Release ◽  
Citrate Buffer ◽  
Buffer Composition ◽  
The Right ◽  
Vitro Release

<p>The effect of different buffers on in vitro release of PEG coated mesoporous silica nanoparticles is discussed in this work. We prepared Rhodamine loaded and PEG coated mesoporous silica nanoparticles (PEG coated RhB@MSNs) of ~ 650 nm size and studied their release behaviour for 5 hours in various buffer solutions (both Na+ and K+ versions) prepared by standard procedure. We observed that Rhodamine release was highest in the citrate buffer. A comparison of different buffer effects on the in vitro release reveals that it is crucial to choose the right buffer for determining the loaded cargo release in each pH zone (acidic, neutral and basic). Clearly, choosing the wrong combination of buffers for different pH zones would result in completely different interpretation of the release behaviour.</p><div><br></div>

scholarly journals pH Responsive in Vitro Cargo Release of PEG Coated MSNs Is Governed by Buffer Composition

2020 ◽  
Author(s):  
Nidhi Sapre ◽  
Gaurav Das ◽  
Sneha Bajpe
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Standard Procedure ◽  
In Vitro Release ◽  
Citrate Buffer ◽  
Buffer Composition ◽  
The Right ◽  
Vitro Release

<p>The effect of different buffers on in vitro release of PEG coated mesoporous silica nanoparticles is discussed in this work. We prepared Rhodamine loaded and PEG coated mesoporous silica nanoparticles (PEG coated RhB@MSNs) of ~ 650 nm size and studied their release behaviour for 5 hours in various buffer solutions (both Na+ and K+ versions) prepared by standard procedure. We observed that Rhodamine release was highest in the citrate buffer. A comparison of different buffer effects on the in vitro release reveals that it is crucial to choose the right buffer for determining the loaded cargo release in each pH zone (acidic, neutral and basic). Clearly, choosing the wrong combination of buffers for different pH zones would result in completely different interpretation of the release behaviour.</p><div><br></div>

Study on in vitro release patterns of fentanyl-loaded PLGA microspheres

2003 ◽  
Vol 20 (5) ◽  
pp. 569-579 ◽  
Author(s):  
S.-A. Seo ◽  
G. Khang ◽  
J. M. Rhee ◽  
J. Kim ◽  
H. B. Lee
Keyword(s):  
In Vitro Release ◽  
Plga Microspheres ◽  
Vitro Release

Reliability of a Single β-Thromboglobulin Measurement in a Diabetic Population : Importance of PGE1 in Anticoagulant Mixture

1987 ◽  
Vol 57 (02) ◽  
pp. 201-204 ◽  
Author(s):  
P Y Scarabin ◽  
L Strain ◽  
C A Ludlam ◽  
J Jones ◽  
E M Kohner
Keyword(s):  
In Vitro Release ◽  
Mean Value ◽  
Reliable Estimate ◽  
Diabetic Patients ◽  
Single Measurement ◽  
Diabetic Population ◽  
The Difference ◽  
Vitro Release

SummaryDuring the collection of samples for plasma β-thromboglobulin (β-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single β-TG measurement, blood samples were collected simultaneously from both arms on two separate occasions in 56 diabetic patients selected for a clinical trial. From each arm, blood was taken into two tubes containing an anticoagulant mixture with (tube A) and without (tube B) PGE!. The overall mean value of B-TG in tube B was 1.14 times higher than in tube A (p <0.01). The markedly large between-arms variation accounted for the most part of within-subject variation in both tubes and was significantly greater in tube B than in tube A. Based on the difference between B-TG values from both arms, the number of subjects with artifically high B-TG values was significantly higher in tube B than in tube A on each occasion (overall rate: 28% and 14% respectively). Estimate of between-occasions variation showed that B-TG levels were relatively stable for each subject between two occasions in each tube. It is concluded that the use of PGEi decreases falsely high B-TG levels, but a single measurement of B-TG does not provide a reliable estimate of the true B-TG value in vivo.

Preparation and In-vitro Evaluation of Fe3O4 Encapsulated by Chitosan Loaded Capecitabine Nanoparticles for the Treatment of Breast Cancer

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Shanmuganathan S. ◽  
Nigma S. ◽  
Anbarasan B. ◽  
Harika B.
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
In Vitro Evaluation ◽  
Sem Image ◽  
Therapeutic Molecules ◽  
Dialysis Method ◽  
Vitro Release

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

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