scholarly journals The role of navigation instruction at intersections for older drivers and those with early Alzheimer’s disease

2016 ◽  
Vol 96 ◽  
pp. 249-254 ◽  
Author(s):  
Laurence Paire-Ficout ◽  
Claude Marin-Lamellet ◽  
Sylviane Lafont ◽  
Catherine Thomas-Antérion ◽  
Bernard Laurent
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Older Drivers ◽  
Early Alzheimer’S Disease

scholarly journals Investigating the role of neuronal oxidative stress in early Alzheimer’s disease pathology

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Morgan K. Foret ◽  
Sonia Do Carmo ◽  
Lindsay A. Welikovitch ◽  
Chiara Orciani ◽  
A. Claudio Cuello
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Alzheimer’S Disease

Low Dose Pioglitazone Attenuates Oxidative Damage in Early Alzheimer's Disease by Binding mitoNEET

2015 ◽  
Vol 5 (1) ◽  
pp. 24-45 ◽  
Author(s):  
Charles D. Hammack ◽  
George Perry ◽  
Richard G. LeBaron ◽  
Greg Villareal ◽  
Clyde F. Phelix
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Damage ◽  
Low Dose ◽  
Mitochondrial Protein ◽  
Central Component ◽  
Protein Levels ◽  
Early Alzheimer’S Disease ◽  
Peroxiredoxin 3

Oxidative damage (OD) is considered to be a central component in the progression of Alzheimer's disease (AD). 8-hydroxyguanosine (8-OHG), a readily oxidized ribonucleic acid found in AD, was used as a biomarker to investigate the role of OD in the progression of the disease. A disruption in two critical Thioredoxin-Dependent Peroxiredoxin System components, peroxiredoxin-3 (Prx-3) and thioredoxin (Trx), may serve as a source of the increased accumulation of OD observed in AD. We demonstrate that OD, in the form of 8-OHG, was quantitatively most significant during the earliest stage of AD [F (3, 25) = 5.08, p < .01]. A drastic decline in mitochondrial protein levels of Prx-3 [F (3, 25) = 8.74, p. < 01] and Trx [F (3, 25) = 4.33, p. < 05] were also observed across the progression of the disease. We then tested the efficacy of pioglitazone, a thiazolidinedione class drug aimed to delay onset of AD by acting on mitoNEET. Our results showed a significant reduction in the oxidized variant of mitoNEET within the incipient population when a 0.8mg dose was simulated in silico (p = 0.0242; a. < 05).

The role of anterior prefrontal cortex in prospective memory: an exploratory FDG-PET study in early Alzheimer's disease

2020 ◽  
Vol 96 ◽  
pp. 117-127
Author(s):  
Federico Massa ◽  
Stefano Grisanti ◽  
Andrea Brugnolo ◽  
Elisa Doglione ◽  
Beatrice Orso ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prefrontal Cortex ◽  
Prospective Memory ◽  
Fdg Pet ◽  
Early Alzheimer’S Disease ◽  
Anterior Prefrontal Cortex
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