scholarly journals Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy

2016 ◽  
pp. 81-126 ◽  
Author(s):  
X. Jiang ◽  
M. Lachance ◽  
E. Rossignol
Keyword(s):  
Basket Cells ◽  
Fast Spiking

scholarly journals CaV2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Elsa Rossignol ◽  
Illya Kruglikov ◽  
Arn M. J. M. van den Maagdenberg ◽  
Bernardo Rudy ◽  
Gord Fishell
Keyword(s):  
Basket Cells ◽  
Generalized Seizures ◽  
Cortical Interneurons ◽  
Fast Spiking

scholarly journals Efficient Ca2+buffering in fast-spiking basket cells of rat hippocampus

2008 ◽  
Vol 586 (8) ◽  
pp. 2061-2075 ◽  
Author(s):  
Yexica Aponte ◽  
Josef Bischofberger ◽  
Peter Jonas
Keyword(s):  
Rat Hippocampus ◽  
Basket Cells ◽  
Fast Spiking

scholarly journals Cannabinoids attenuate hippocampal gamma oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells

2011 ◽  
Vol 589 (20) ◽  
pp. 4921-4934 ◽  
Author(s):  
Noémi Holderith ◽  
Beáta Németh ◽  
Orsolya I. Papp ◽  
Judit M. Veres ◽  
Gergő A. Nagy ◽  
...  
Keyword(s):  
Synaptic Input ◽  
Pyramidal Neurons ◽  
Gamma Oscillations ◽  
Basket Cells ◽  
Excitatory Synaptic Input ◽  
Fast Spiking ◽  
Ca3 Pyramidal Neurons

scholarly journals Conduction velocity along the local axons of parvalbumin interneurons correlates with the degree of axonal myelination

2020 ◽  
Author(s):  
Kristina D. Micheva ◽  
Marianna Kiraly ◽  
Marc M. Perez ◽  
Daniel V. Madison
Keyword(s):  
Action Potential ◽  
Conduction Velocity ◽  
Postsynaptic Currents ◽  
Basket Cells ◽  
Adult Mice ◽  
Array Tomography ◽  
Parvalbumin Interneurons ◽  
Fast Spiking ◽  
Whole Cell Recordings ◽  
Postsynaptic Target

AbstractParvalbumin-containing (PV+) basket cells in mammalian neocortex are fast-spiking interneurons that regulate the activity of local neuronal circuits in multiple ways. Even though PV+ basket cells are locally projecting interneurons, their axons are myelinated. Can this myelination contribute in any significant way to the speed of action potential propagation along such short axons? We used dual whole cell recordings of synaptically connected PV+ interneurons and their postsynaptic target in acutely-prepared neocortical slices from adult mice to measure the amplitude and latency of single presynaptic action potential-evoked inhibitory postsynaptic currents (IPSCs). These same neurons were then imaged with immunofluorescent array tomography, the synaptic contacts between them identified and a precise map of the connections was generated, with the exact axonal length and extent of myelin coverage. Our results support that myelination of PV+ basket cells significantly increases conduction velocity, and does so to a degree that can be physiologically relevant.

scholarly journals Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells

2013 ◽  
Vol 109 (7) ◽  
pp. 1746-1763 ◽  
Author(s):  
Jiandong Yu ◽  
Archana Proddutur ◽  
Fatima S. Elgammal ◽  
Takahiro Ito ◽  
Vijayalakshmi Santhakumar
Keyword(s):  
Status Epilepticus ◽  
Granule Cell ◽  
Feedback Inhibition ◽  
Reversal Potential ◽  
Resting Membrane Potential ◽  
Activity Levels ◽  
Basket Cells ◽  
Afferent Activation ◽  
Fast Spiking ◽  
Cell Inhibition

Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether dentate basket cells critical for regulating granule cell feedforward and feedback inhibition express tonic GABA currents ( IGABA) and undergo changes in inhibition after SE is not known. We find that interneurons immunoreactive for parvalbumin in the hilar-subgranular region express GABAA receptor (GABAAR) δ-subunits, which are known to underlie tonic IGABA. Dentate fast-spiking basket cells (FS-BCs) demonstrate baseline tonic IGABA blocked by GABAAR antagonists. In morphologically and physiologically identified FS-BCs, tonic IGABA is enhanced 1 wk after pilocarpine-induced SE, despite simultaneous reduction in spontaneous inhibitory postsynaptic current (sIPSC) frequency. Amplitude of tonic IGABA in control and post-SE FS-BCs is enhanced by 4,5,6,7-tetrahydroisoxazolo[5,4- c]pyridin-3-ol (THIP), demonstrating the contribution of GABAAR δ-subunits. Whereas FS-BC resting membrane potential is unchanged after SE, perforated-patch recordings from FS-BCs show that the reversal potential for GABA currents ( EGABA) is depolarized after SE. In model FS-BCs, increasing tonic GABA conductance decreased excitability when EGABA was shunting and increased excitability when EGABA was depolarizing. Although simulated focal afferent activation evoked seizurelike activity in model dentate networks with FS-BC tonic GABA conductance and shunting EGABA, excitability of identical networks with depolarizing FS-BC EGABA showed lower activity levels. Thus, together, post-SE changes in tonic IGABA and EGABA maintain homeostasis of FS-BC activity and limit increases in dentate excitability. These findings have implications for normal FS-BC function and can inform studies examining comorbidities and therapeutics following SE.

scholarly journals Parvalbumin-Positive Basket Interneurons in Monkey and Rat Prefrontal Cortex

2008 ◽  
Vol 100 (4) ◽  
pp. 2348-2360 ◽  
Author(s):  
N. V. Povysheva ◽  
A. V. Zaitsev ◽  
D. C. Rotaru ◽  
G. Gonzalez-Burgos ◽  
D. A. Lewis ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Cortical Neurons ◽  
Input Resistance ◽  
Cell Types ◽  
Threshold Current ◽  
Electrophysiological Properties ◽  
Basket Cells ◽  
Physiological Properties ◽  
Axonal Arbor ◽  
Fast Spiking

Differences in the developmental origin and relative proportions of biochemically distinct classes of cortical neurons have been found between rodents and primates. In addition, species differences in the properties of certain cell types, such as neurogliaform cells, have also been reported. Consequently, in this study we compared the anatomical and physiological properties of parvalbumin (PV)-positive basket interneurons in the prefrontal cortex of macaque monkeys and rats. The somal size, total dendritic length, and horizontal and vertical spans of the axonal arbor were similar in monkeys and rats. Physiologically, PV basket cells could be identified as fast-spiking interneurons in both species, based on their short spike and high-frequency firing without adaptation. However, important interspecies differences in the intrinsic physiological properties were found. In monkeys, basket cells had a higher input resistance and a lower firing threshold, and they generated more spikes at near-threshold current intensities than those in rats. Thus monkey basket cells appeared to be more excitable. In addition, rat basket cells consistently fired the first spike with a substantial delay and generated spike trains interrupted by quiescent periods more often than monkey basket cells. The frequency of miniature excitatory postsynaptic potentials in basket cells was considerably higher in rats than that in monkeys. These differences between rats and monkeys in the electrophysiological properties of PV-positive basket cells may contribute to the differential patterns of neuronal activation observed in rats and monkeys performing working-memory tasks.

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