scholarly journals A Semiautomated Assignment Protocol for Methyl Group Side Chains in Large Proteins

2016 ◽  
pp. 35-57 ◽  
Author(s):  
Jonggul Kim ◽  
Yingjie Wang ◽  
Geoffrey Li ◽  
Gianluigi Veglia
Keyword(s):  
Side Chains ◽  
Methyl Group ◽  
Large Proteins

A Cost-Effective Labeling Strategy for the NMR Study of Large Proteins: Selective15N-Labeling of the Tryptophan Side Chains of Prolyl Oligopeptidase

ChemBioChem ◽  
2009 ◽  
Vol 10 (17) ◽  
pp. 2736-2739 ◽  
Author(s):  
Teresa Tarragó ◽  
Birgit Claasen ◽  
Nessim Kichik ◽  
Ricard A. Rodriguez-Mias ◽  
Margarida Gairí ◽  
...  
Keyword(s):  
Cost Effective ◽  
Side Chains ◽  
Prolyl Oligopeptidase ◽  
Large Proteins ◽  
Nmr Study ◽  
Tryptophan Side Chains

scholarly journals Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

2008 ◽  
Vol 28 (10) ◽  
pp. 3301-3312 ◽  
Author(s):  
Marcus J. O. Johansson ◽  
Anders Esberg ◽  
Bo Huang ◽  
Glenn R. Björk ◽  
Anders S. Byström
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Side Chain ◽  
Side Chains ◽  
Methyl Group ◽  
Wobble Position ◽  
Naturally Occurring

ABSTRACT The translational decoding properties of tRNAs are modulated by naturally occurring modifications of their nucleosides. Uridines located at the wobble position (nucleoside 34 [U34]) in eukaryotic cytoplasmic tRNAs often harbor a 5-methoxycarbonylmethyl (mcm5) or a 5-carbamoylmethyl (ncm5) side chain and sometimes an additional 2-thio (s2) or 2′-O-methyl group. Although a variety of models explaining the role of these modifications have been put forth, their in vivo functions have not been defined. In this study, we utilized recently characterized modification-deficient Saccharomyces cerevisiae cells to test the wobble rules in vivo. We show that mcm5 and ncm5 side chains promote decoding of G-ending codons and that concurrent mcm5 and s2 groups improve reading of both A- and G-ending codons. Moreover, the observation that the mcm5U34- and some ncm5U34-containing tRNAs efficiently read G-ending codons challenges the notion that eukaryotes do not use U-G wobbling.

Synthèse d'isoxazoles substitués en α de l'oxygène et d'isoxazoles substitués en α de l'azote et de l'oxygène par des chaînes alkyle ou alcényle

1991 ◽  
Vol 69 (4) ◽  
pp. 625-631 ◽  
Author(s):  
Jean-Claude Cherton ◽  
M. Lanson ◽  
D. Ladjama ◽  
N. Lefebvre ◽  
Z. Vossough ◽  
...  
Keyword(s):  
Oxygen Atom ◽  
Key Words ◽  
Dipolar Cycloaddition ◽  
Side Chains ◽  
Alternative Route ◽  
Methyl Group ◽  
Additional Step ◽  
Alkenyl Chain ◽  
Convenient Route

Two series of isoxazoles substituted by long alkyl or alkenyl chains in the α position with respect to the oxygen atom or in the α position with respect to the two heteroatoms have been synthesized. Starting from 3,5-dimethylisoxazole, the regioselective metalation/alkylation on the α-O methyl group was a very convenient route to a large variety of "α-O substituted isoxazoles". When applied to α-O methylated isoxazoles bearing an α-N alkenyl chain the same method provides an original unequivocal approach to 3,5-dialkenyl isoxazoles. An alternative route to these compounds, despite the formation of di-isoxazoline as by-product and an additional step corresponding to the oxidation of the intermediate isoxazoline, is the 1,3-dipolar cycloaddition, by using terminal dienes as dipolarophiles with alkenyl dipoles. Nevertheless, the cycloaddition between monoalkylated alcynes and alkylated dipoles remains the most straightforward synthesis of 3,5-dialkyl isoxazoles. Key words: isoxazoles, alkenyl side chains, metalation–alkylation, regioselectivity.

Fluorination of a polymer donor through the trifluoromethyl group for high-performance polymer solar cells

2020 ◽  
Vol 8 (24) ◽  
pp. 12149-12155 ◽  
Author(s):  
Chao Yao ◽  
Yanan Zhu ◽  
Kaichen Gu ◽  
Jiajun Zhao ◽  
Jiaoyi Ning ◽  
...  
Keyword(s):  
Solar Cells ◽  
High Performance ◽  
Polymer Solar Cells ◽  
Side Chains ◽  
Trifluoromethyl Group ◽  
Methyl Group ◽  
High Performance Polymer ◽  
Improved Performance

Polymer donor F0 is fluorinated to F1 through converting methyl group to trifluoromethyl group on side chains. F1 exhibits remarkably improved performance in polymer solar cells with a highest PCE of 13.5%.

Use of [13C-methyl]Tropinone to follow the fate of the methyl group during calystegine formation in root cultures of Solanum dulcamara (Solanaceae)

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
TA Bartholomeusz ◽  
R Molinié ◽  
A Roscher ◽  
AC Freydank ◽  
B Dräger ◽  
...  
Keyword(s):  
Root Cultures ◽  
Solanum Dulcamara ◽  
Methyl Group
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