Zebrafish models of human eye and inner ear diseases

2017 ◽  
pp. 415-467 ◽  
Author(s):  
B. Blanco-Sánchez ◽  
A. Clément ◽  
J.B. Phillips ◽  
M. Westerfield
Keyword(s):  
Inner Ear ◽  
Ear Diseases ◽  
Human Eye

scholarly journals Ultrasound Microbubbles Enhance the Efficacy of Insulin-Like Growth Factor-1 Therapy for the Treatment of Noise-Induced Hearing Loss

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3626
Author(s):  
Yi-Chun Lin ◽  
Yuan-Yung Lin ◽  
Hsin-Chien Chen ◽  
Chao-Yin Kuo ◽  
Ai-Ho Liao ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Growth Factor ◽  
Inner Ear ◽  
Outer Hair Cells ◽  
Round Window Membrane ◽  
Insulin Like Growth Factor ◽  
Noise Induced Hearing Loss ◽  
Ear Diseases ◽  
Brainstem Response ◽  
Ultrasound Microbubbles

The application of insulin-like growth factor 1 (IGF-1) to the round window membrane (RWM) is an emerging treatment for inner ear diseases. RWM permeability is the key factor for efficient IGF-1 delivery. Ultrasound microbubbles (USMBs) can increase drug permeation through the RWM. In the present study, the enhancing effect of USMBs on the efficacy of IGF-1 application and the treatment effect of USMB-mediated IGF-1 delivery for noise-induced hearing loss (NIHL) were investigated. Forty-seven guinea pigs were assigned to three groups: the USM group, which received local application of recombinant human IGF-1 (rhIGF-1, 10 µg/µL) following application of USMBs to the RWM; the RWS group, which received IGF-1 application alone; and the saline-treated group. The perilymphatic concentration of rhIGF-1 in the USM group was 1.95- and 1.67- fold of that in the RWS group, 2 and 24 h after treatment, respectively. After 5 h of 118 dB SPL noise exposure, the USM group had the lowest threshold shift in auditory brainstem response, least loss of cochlear outer hair cells, and least reduction in the number of synaptic ribbons on postexposure day 28 among the three groups. The combination of USMB and IGF-1 led to a better therapeutic response to NIHL. Two hours after treatment, the USM group had significantly higher levels of Akt1 and Mapk3 gene expression than the other two groups. The most intense immunostaining for phosphor-AKT and phospho-ERK1/2 was detected in the cochlea in the USM group. These results suggested that USMB can be applied to enhance the efficacy of IGF-1 therapy in the treatment of inner ear diseases.

Cochlear implant in immune mediated inner ear diseases: Impedance variations and clinical outcomes

2021 ◽  
pp. 1-10
Author(s):  
Francesca Atturo ◽  
Ginevra Portanova ◽  
Francesca Yoshie Russo ◽  
Daniele De Seta ◽  
Laura Mariani ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Inner Ear ◽  
Clinical Outcomes ◽  
Ear Diseases ◽  
Immune Mediated

Antibodies against inner ear proteins in the sera of patients with inner ear diseases

2003 ◽  
Vol 1240 ◽  
pp. 1163-1167 ◽  
Author(s):  
M Suzuki ◽  
M.S Krug ◽  
K.C Cheng ◽  
Y Yazawa ◽  
J Bernstein ◽  
...  
Keyword(s):  
Inner Ear ◽  
Ear Diseases

Chronic cerebrospinal venous insufficiency as a cause of inner ear diseases

2016 ◽  
Vol 137 (5) ◽  
pp. 460-463 ◽  
Author(s):  
Giuseppe Attanasio ◽  
Laura Cagnoni ◽  
Eleonora Masci ◽  
Francesco Ciciarello ◽  
Francesco Diaferia ◽  
...  
Keyword(s):  
Inner Ear ◽  
Venous Insufficiency ◽  
Ear Diseases ◽  
Chronic Cerebrospinal Venous Insufficiency

Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015)

2016 ◽  
Vol 27 (2) ◽  
pp. 191-202 ◽  
Author(s):  
Kim Nguyen ◽  
Judith S. Kempfle ◽  
David H. Jung ◽  
Charles E. McKenna
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Ear Diseases ◽  
Recent Advances ◽  
Patent Review

Cell Therapy for Inner Ear Diseases

2005 ◽  
Vol 11 (9) ◽  
pp. 1203-1207 ◽  
Author(s):  
T. Nakagawa ◽  
J. Ito
Keyword(s):  
Cell Therapy ◽  
Inner Ear ◽  
Ear Diseases

A Novel Drug Delivery System: A Biodegradable Gel for the Treatment of Inner Ear Diseases

2004 ◽  
Vol 131 (2) ◽  
pp. P260-P260 ◽  
Author(s):  
Tsuyoshi Endo ◽  
Takayuki Nakagawa ◽  
Tomoko Kita ◽  
Tae Soo Kim ◽  
Fukuichiro Iguchi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ear Diseases ◽  
System A ◽  
Novel Drug Delivery System ◽  
Novel Drug
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