A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain

2016 ◽  
pp. 89-161 ◽  
Author(s):  
C. Kibaly ◽  
H.H. Loh ◽  
P.-Y. Law
Keyword(s):  
Gene Therapy ◽  
Chronic Pain ◽  
Mechanistic Approach

scholarly journals Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNFα

2008 ◽  
Vol 437 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Marina Mata ◽  
Shuanglin Hao ◽  
David J. Fink
Keyword(s):  
Gene Therapy ◽  
Chronic Pain

scholarly journals Development of Viral Vectors for Gene Therapy for Chronic Pain

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Yu Huang ◽  
Xin Liu ◽  
Lanlan Dong ◽  
Zhongchun Liu ◽  
Xiaohua He ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Chronic Pain ◽  
Viral Vectors ◽  
Treatment Strategies ◽  
Opioid Analgesics ◽  
Cell Types ◽  
Health Concern ◽  
Specific Cell ◽  
New Treatment ◽  
The Individual

Chronic pain is a major health concern that affects millions of people. There are no adequate long-term therapies for chronic pain sufferers, leading to significant cost for both society and the individual. The most commonly used therapy for chronic pain is the application of opioid analgesics and nonsteroidal anti-inflammatory drugs, but these drugs can lead to addiction and may cause side effects. Further studies of the mechanisms of chronic pain have opened the way for development of new treatment strategies, one of which is gene therapy. The key to gene therapy is selecting safe and highly efficient gene delivery systems that can deliver therapeutic genes to overexpress or suppress relevant targets in specific cell types. Here we review several promising viral vectors that could be applied in gene transfer for the treatment of chronic pain and further discuss the possible mechanisms of genes of interest that could be delivered with viral vectors for the treatment of chronic pain.

scholarly journals Current Gene Therapy using Viral Vectors for Chronic Pain

2015 ◽  
Vol 11 ◽  
pp. s12990-015-0018 ◽  
Author(s):  
Jean-Marc G Guedon ◽  
Shaogen Wu ◽  
Xuexing Zheng ◽  
Caroline C Churchill ◽  
Joseph C Glorioso ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Chronic Pain ◽  
Viral Vectors

scholarly journals Applications of Gene Therapy to the Treatment of Chronic Pain

2008 ◽  
Vol 8 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Marina Mata ◽  
Shuanglin Hao ◽  
David Fink
Keyword(s):  
Gene Therapy ◽  
Chronic Pain

Gene Therapy for Chronic Pain

2008 ◽  
pp. 473-491
Author(s):  
William R. Lariviere ◽  
Doris K. Cope
Keyword(s):  
Gene Therapy ◽  
Chronic Pain
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