China–Africa and China–Asia Collaboration on Schistosomiasis Control

2016 ◽  
pp. 435-466 ◽  
Author(s):  
J. Xu ◽  
R. Bergquist ◽  
Y.-J. Qian ◽  
Q. Wang ◽  
Q. Yu ◽  
...  
Keyword(s):  
Schistosomiasis Control

scholarly journals The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 234
Author(s):  
Erika M. Stein ◽  
Sara G. Tajú ◽  
Patrícia A. Miyasato ◽  
Rafaela P. de Freitas ◽  
Lenita de F. Tallarico ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Marine Algae ◽  
Pearson Correlation ◽  
Marine Macroalgae ◽  
Parasitic Disease ◽  
Isolation And Identification ◽  
Promising Alternative ◽  
Schistosomiasis Control ◽  
Lead Compounds ◽  
Correlation Tests

Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against Biomphalaria glabrata embryos and schistosomicidal activities against Schistosoma mansoni. Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC–MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against B. glabrata veliger embryos in the Laurencia/Laurenciella set, 5 hits against B. glabrata blastula embryos, and 31 against S. mansoni in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identification.

scholarly journals Effectiveness of the new integrated strategy to control the transmission of Schistosoma japonicum in China: a systematic review and meta-analysis

Parasite ◽  
2018 ◽  
Vol 25 ◽  
pp. 54 ◽  
Author(s):  
Chunyan Qian ◽  
Yuefeng Zhang ◽  
Xinyan Zhang ◽  
Chao Yuan ◽  
Zhichao Gao ◽  
...  
Keyword(s):  
Schistosoma Japonicum ◽  
Control Strategy ◽  
Meta Analysis ◽  
Infection Risk ◽  
Oncomelania Hupensis ◽  
Local Conditions ◽  
Schistosomiasis Control ◽  
Integrated Strategy ◽  
New Strategy ◽  
Morbidity Control

Since 2004, the national schistosomiasis control strategy in China has shifted from the morbidity control strategy (conventional strategy) to an integrated strategy (new strategy). We investigated the effectiveness of the new strategy and compared it against the conventional strategy. We retrieved from electronic databases the literature regarding the new strategy published from 2000 to 2017. The effect of the new or conventional strategy on infection by Schistosoma japonicum of humans and snails (Oncomelania hupensis) was evaluated with pooled log relative risk (logRR). A total of only eight eligible publications were included in the final meta-analysis. The results showed that implementation of the new strategy reduced the infection risk by 3–4 times relative to the conventional strategy. More specifically, the conventional strategy caused a reduction in both human (logRR = 0.56, 95% CI: 0.12–0.99) and snail infections (logRR = 0.34, 95% CI: −0.69–1.37), while the new strategy also significantly reduced both human (logRR = 1.89, 95% CI: 1.33–2.46) and snail infections (logRR = 1.61, 95% CI: 1.06–2.15). In contrast to the conventional strategy, the new strategy appeared more effective to control both human (logRR difference = 1.32, 95% CI: 0.78–1.86) and snail infections (logRR difference = 1.53, 95% CI: 0.76–2.31). Our data demonstrate that the new integrated strategy is highly effective to control the transmission of S. japonicum in China, and this strategy is recommended for schistosomiasis elimination in other affected regions across the world, with adaptation to local conditions.

scholarly journals Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination

2018 ◽  
Vol 3 (3) ◽  
pp. 100 ◽  
Author(s):  
Harrison Korir ◽  
Diana Riner ◽  
Emmy Kavere ◽  
Amos Omondi ◽  
Jasmine Landry ◽  
...  
Keyword(s):  
Young Adults ◽  
Point Of Care ◽  
Intensity Of Infection ◽  
Preventive Chemotherapy ◽  
Schistosomiasis Control ◽  
Soil Transmitted Helminths ◽  
College And University ◽  
School Based ◽  
College Setting ◽  
University Settings

Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students and staff at the Kisumu National Polytechnic in Kisumu, Kenya, using the stool microscopy Kato-Katz (KK) method and the urine point-of-care circulating cathodic antigen (POC-CCA) test. Based on three stools/two KK slides each, in the 208 participants for whom three consecutive stools were obtained, Schistosoma mansoni prevalence was 17.8%. When all 291 individuals were analyzed based on the first stool, as done by the national neglected tropical disease (NTD) program, and one urine POC-CCA assay (n = 276), the prevalence was 13.7% by KK and 23.2% by POC-CCA. Based on three stools, 2.5% of 208 participants had heavy S. mansoni infections (≥400 eggs/gram feces), with heavy S. mansoni infections making up 13.5% of the S. mansoni cases. The prevalence of the soil-transmitted helminths (STH: Ascaris lumbricoides, Trichuris trichiura and hookworm) by three stools was 1.4%, 3.1%, and 4.1%, respectively, and by the first stool was 1.4%, 2.4% and 1.4%, respectively. This prevalence and intensity of infection with S. mansoni in a college setting warrants mass drug administration with praziquantel. This population of young adults is ‘in school’ and is both approachable and worthy of inclusion in national schistosomiasis control and elimination programs.

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