scholarly journals Preprocessing differential methylation hybridization microarray data

2011 ◽  
Vol 4 (1) ◽  
Author(s):  
Shuying Sun ◽  
Yi-Wen Huang ◽  
Pearlly S Yan ◽  
Tim HM Huang ◽  
Shili Lin
Keyword(s):  
Microarray Data ◽  
Differential Methylation ◽  
Differential Methylation Hybridization

Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers

2007 ◽  
Vol 13 (10) ◽  
pp. 2882-2889 ◽  
Author(s):  
Israel Zighelboim ◽  
Paul J. Goodfellow ◽  
Amy P. Schmidt ◽  
Ken C. Walls ◽  
Mary Ann Mallon ◽  
...  
Keyword(s):  
Differential Methylation ◽  
Differential Methylation Hybridization ◽  
Endometrial Cancers

Vestibular Schwannoma Clinical Phenotypes Are Associated with Differential Methylation Patterns

2020 ◽  
Author(s):  
Avital Perry ◽  
Christopher S. Graffeo ◽  
Lucas P. Carlstrom ◽  
Amanda Munoz Casabella ◽  
Matthew L. Carlson ◽  
...  
Keyword(s):  
Vestibular Schwannoma ◽  
Differential Methylation ◽  
Clinical Phenotypes ◽  
Methylation Patterns

scholarly journals Differential Methylation in the GSTT1 Regulatory Region in Sudden Unexplained Death and Sudden Unexpected Death in Epilepsy

2021 ◽  
Vol 22 (6) ◽  
pp. 2790
Author(s):  
Steffan Noe Christiansen ◽  
Stine Bøttcher Jacobsen ◽  
Jeppe Dyrberg Andersen ◽  
Marie-Louise Kampmann ◽  
Linea Christine Trudsø ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cardiac Tissue ◽  
Heart Diseases ◽  
Regulatory Region ◽  
Differential Methylation ◽  
Sudden Unexpected Death ◽  
Diagnostic Challenge ◽  
Unexpected Death ◽  
Sudden Unexplained Death ◽  
Unexplained Death

Sudden cardiac death (SCD) is a diagnostic challenge in forensic medicine. In a relatively large proportion of the SCDs, the deaths remain unexplained after autopsy. This challenge is likely caused by unknown disease mechanisms. Changes in DNA methylation have been associated with several heart diseases, but the role of DNA methylation in SCD is unknown. In this study, we investigated DNA methylation in two SCD subtypes, sudden unexplained death (SUD) and sudden unexpected death in epilepsy (SUDEP). We assessed DNA methylation of more than 850,000 positions in cardiac tissue from nine SUD and 14 SUDEP cases using the Illumina Infinium MethylationEPIC BeadChip. In total, six differently methylated regions (DMRs) between the SUD and SUDEP cases were identified. The DMRs were located in proximity to or overlapping genes encoding proteins that are a part of the glutathione S-transferase (GST) superfamily. Whole genome sequencing (WGS) showed that the DNA methylation alterations were not caused by genetic changes, while whole transcriptome sequencing (WTS) showed that DNA methylation was associated with expression levels of the GSTT1 gene. In conclusion, our results indicate that cardiac DNA methylation is similar in SUD and SUDEP, but with regional differential methylation in proximity to GST genes.

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