MOTT (Mycobacteria Other than Tuberculosis)

2012 ◽  
Keyword(s):  
Mycobacteria Other Than Tuberculosis

scholarly journals Incidence of Pulmonary Disease Caused by Mycobacteria other than Tuberculosis in British Columbia

2002 ◽  
Vol 9 (5) ◽  
pp. 319-323 ◽  
Author(s):  
R Kevin Elwood ◽  
Anabelle M Opazo Saez ◽  
Vittorio Lentini ◽  
Ramak Shadmani
Keyword(s):  
British Columbia ◽  
Incidence Rate ◽  
Pulmonary Disease ◽  
Industrialized Countries ◽  
Foreign Born ◽  
Drug Intolerance ◽  
History Of ◽  
Mycobacterium Avium Intracellulare ◽  
Considerable Morbidity ◽  
Mycobacteria Other Than Tuberculosis

CONTEXT: The incidence of pulmonary disease due to mycobacteria other than tuberculosis (TB) in Canada has not been documented.OBJECTIVE: To determine the incidence of pulmonary disease due to mycobacteria in the nonimmunocompromised population of British Columbia.DESIGN: A retrospective cohort study of 110 cases of mycobacteria infection other than TB identified from 1991 to 1995.SETTING: British Columbia Centre for Disease Control, Division of TB Control.RESULTS: The overall incidence rate of infection with mycobacteria other than TB was 0.63×10-5/year. This incidence rate was significantly higher among women (relative risk [RR]=2, P=0.0006) and in those aged 55 years or older (RR=8, P<0.00001). In contrast with TB, patients were more frequently born in Canada (P<0.00001) or in industrialized countries other than Canada (P<0.00001), and were less likely to be Aboriginal (P=0.0007) or foreign born from Asia (P<0.0001). The most common organism isolated in British Columbia was Mycobacterium avium-intracellulare (82.7%). Overall, 78 (71%) cases had underlying lung disease. Drug intolerance was very common (42%). After treatment, 55% and 41% of the patients were rendered smear negative or culture negative, respectively. Radiological improvement was noted in 55% of patients, and 60% of patients responded symptomatically to treatment.CONCLUSIONS: The overall incidence of pulmonary disease is low. It is a disease predominantly of women 55 years and older, and targets completely different ethnic groups than TB, suggesting a protective effect of infection with Mycobacterium tuberculosis. M avium-intracellulare was the most common pathogen isolated. Further investigation is required into the natural history of so-called 'colonizers'. Considerable morbidity may be prevented with earlier intervention.

The Role of Mycobacteria Other Than Tuberculosis (MOTT) in Patients with Cystic Fibrosis

1994 ◽  
Vol 26 (5) ◽  
pp. 569-576 ◽  
Author(s):  
Karsten Hjelt ◽  
Niels Højlyng ◽  
Peter Howitz ◽  
Niels Illum ◽  
Erik Munk ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Mycobacteria Other Than Tuberculosis

scholarly journals Prevalence of opportunistic infections in HIV-positive patients in Bahrain: a four-year review (2009-2013)

2015 ◽  
Vol 9 (01) ◽  
pp. 060-069 ◽  
Author(s):  
Nermin Kamal Saeed ◽  
Eman Farid ◽  
Afaf E Jamsheer
Keyword(s):  
Bacterial Infections ◽  
Opportunistic Infections ◽  
Arab World ◽  
Cd4 Count ◽  
Hiv Positive ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Cd4 Counts ◽  
Significant Difference ◽  
Streptococcus Milleri ◽  
Mycobacteria Other Than Tuberculosis

Introduction: This study aimed to examine the prevalence of opportunistic infections in HIV-infected patients in Bahrain and its relation to absolute CD4 count, CD4%, and CD4/CD8 ratio. Methodology: This retrospective cohort study used laboratory records (January 2009 - May 2013) from a major hospital in Bahrain. Opportunistic infections (OIs); absolute CD4 counts, CD4%, and CD4/CD8 ratio were recorded. Results: CD4% and absolute CD4 count in HIV patients with associated infections (157 ± 295) was significantly lower than in those without associated infections (471 ± 285) (p < 0.001). There was no significant difference in CD4/CD8 ratio between the two groups. Infection with Staphylococcus aureus was the commonest infection, present in 9.8% of total HIV-infected patients and 28.7% of members of the AIDS patient group with OIs, followed by yeast infections (9.2% and 27.2%, respectively). Mycobacterium tuberculosis was present in 3.6% of total HIV-infected patients and 10.6% of the group with OIs, while mycobacteria other than tuberculosis (MOTT) was present in 2.5% and 7.5%, respectively. Pneumocystis jirovecii pneumonia (PCP) was observed in 5.1% and 15.1%, respectively. Herpes simplex II (HSV-II) was observed in 3% and 9%, respectively, while Cytomegalovirus antigenemia was only present in 2% and 6%, respectively. Streptococcus pneumoniae, Streptococcus milleri, Stenotrophomonas maltophilia, and Citrobacter species were bacterial infections observed least frequently. Conclusions: Studying the pattern of OIs in HIV-infected patients in Bahrain is of paramount importance due to the scarcity of data in the Arab world. This will help to improve physicians’ awareness to improve care of HIV-infected patients.

Cervical Lymphadenitis due to Mycobacteria Other Than Tuberculosis – An Emerging Problem in Children?

ORL ◽  
1995 ◽  
Vol 57 (1) ◽  
pp. 36-38 ◽  
Author(s):  
Gernot Kuth ◽  
Jürgen Lamprecht ◽  
Gerhard Haase
Keyword(s):  
Cervical Lymphadenitis ◽  
Mycobacteria Other Than Tuberculosis

scholarly journals Mycobacterium marinum infection complicated by anti-tumour necrosis factor therapy

2010 ◽  
Vol 59 (5) ◽  
pp. 617-621 ◽  
Author(s):  
José M. Ramos ◽  
Mariana F. García-Sepulcre ◽  
Juan C. Rodríguez ◽  
Sergio Padilla ◽  
Félix Gutiérrez
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Mycobacterium Marinum ◽  
Local Spread ◽  
Systemic Dissemination ◽  
Factor Therapy ◽  
Necrosis Factor ◽  
Mycobacteria Other Than Tuberculosis

Mycobacteria other than tuberculosis infections in patients taking various tumour necrosis factor (TNF)-α inhibitors have been reported in the literature. We describe sporotrichoid spread of Mycobacterium marinum in a man with Crohn's disease treated with infliximab. After starting ethambutol and rifampicin and discontinuing infliximab, a worsening appeared. M. marinum infection may have a potential local spread and systemic dissemination in patients treated with TNF-α inhibitors.

scholarly journals Diagnosis dan Tatalaksana Penyakit Paru Nontuberculous mycobacteria

2018 ◽  
Vol 7 ◽  
pp. 141
Author(s):  
Linda Ratna Juita ◽  
Fauzar Fauzar
Keyword(s):  
Nontuberculous Mycobacteria ◽  
Atypical Mycobacteria ◽  
Mycobacteria Other Than Tuberculosis

Nontuberculous mycobacteria (NTM) juga dikenal dengan atypical mycobacteria atau mycobacteria other than tuberculosis merupakan organisme patogen oportunistik yang dapat menyebabkan penyakit paru progresif. Spesies yang paling banyak ditemukan adalah Mycobacteria avium complex (MAC), M. kansasii, M. malmose, dan M. xenopi. Diagnosis penyakit paru NTM berdasarkan manisfestasi klinis dan radiologis (fibrokavitas dan bronkiektasis nodular). Kultur merupakan standar emas untuk konfirmasi laboratorium dari NTM dan diperlukan untuk identifikasi genotipe dan drug suscebtibility test (DST). Antibiotik golongan makrolida seperti azitromisin dan klaritomisin merupakan terapi dasar untuk infeksi paru NTM. Rekomendasi menganjurkan terapi kombinasi makrolida (azitromisin atau klaritromisin), rifampin atau rifabutin, dan etambutol dengan atau tanpa aminoglikosida intravena. Terapi medikamentosa dilakukan secara kontiniu diberikan minimal selama 12 bulan setelah didapatkan biakan sputum negatif.

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