Ciprofloxacin-loaded alginate/poly (vinyl alcohol)/gelatin electrospun nanofiber mats as antibacterial wound dressings

2021 ◽  
pp. 152808372199746
Author(s):  
Tittaya Thairin ◽  
Patcharaporn Wutticharoenmongkol
Keyword(s):  
Weight Loss ◽  
Vinyl Alcohol ◽  
Diffusion Method ◽  
Poly Vinyl Alcohol ◽  
Burst Release ◽  
Electrospun Nanofiber ◽  
Total Immersion ◽  
Water Swelling ◽  
Nanofiber Mats ◽  
And Diffusion

Herein, ciprofloxacin (CIP)-loaded alginate/poly (vinyl alcohol)/gelatin (SPG) (CIP–SPG) nanofiber mats were successfully fabricated by electrospinning. The average fiber diameters of the mats before and after crosslinking were in the range of 190–260 and 385–484 nm, respectively. The chemical integrity of CIP remained intact after encapsulation into the mats. The degree of weight loss and water swelling decreased with an increase in the gelatin content of the electrospun nanofiber mats. A release study was carried out by total immersion and diffusion methods using phosphate buffer as a release medium. Burst release of CIP was observed in case of the total immersion method, while a more sustained release was observed in case of the diffusion method. The maximum amounts of CIP released during total immersion and diffusion were in the range of 70–90% and 72–85%, respectively. For both the total immersion and diffusion methods, the released amounts of CIP decreased and the release slowed down with an increase in the gelatin content; this result is consistent with the weight loss and water swelling values. The Young’s modulus increased, while the tensile strength and strain at break decreased with an increase in the gelatin content. The CIP–SPG nanofiber mats were slightly toxic to L929 mouse fibroblasts as evaluated by indirect cytotoxicity assay. The electrospun CIP–SPG nanofiber mats exhibited excellent antimicrobial activity against Staphylococcus aureus and Escherichia coli. These results reveal that the electrospun CIP–SPG nanofiber mats are potentially promising materials for wound healing applications.

2015 Preview: Prepare for total immersion

2014 ◽  
Vol 224 (3000-3001) ◽  
pp. 27
Author(s):  
Aviva Rutkin
Keyword(s):  
Total Immersion

Metric Advocates Support “Total Immersion” Concept

Opflow ◽  
1975 ◽  
Vol 1 (2) ◽  
pp. 1-2
Author(s):  
Willard Reese ◽  
George Cathcart
Keyword(s):  
Total Immersion

scholarly journals FIRST PERFORMANCES

Tempo ◽  
2009 ◽  
Vol 63 (249) ◽  
pp. 52-67
Keyword(s):  
New York ◽  
Los Angeles ◽  
List Type ◽  
90Th Birthday ◽  
Violin Concerto ◽  
Total Immersion ◽  
The Hague ◽  
Milton Keynes

Munich: Ben-Haim's ‘Joram’ Malcolm MillerLos Angeles: Andriessen's ‘The Hague Hacking’ Jeff DunnNew York: Kirchner 90th Birthday Celebrations Christian CareyMilton Keynes: Wood's Violin Concerto No. 2 Edward VennTewkesbury: Christopher Steel Paul ConwayLondon, Barbican: ‘Total Immersion’ Days John WheatleyLeeds: David Sawer's ‘Skin Deep’ Paul ConwayOpera premières in London Martin Anderson, Malcolm MillerFurther reports from London and St Albans Jill Barlow, Paul Conway, John Wheatley

The Intercultural Language Program in San Diego: Total Immersion

Hispania ◽  
1980 ◽  
Vol 63 (3) ◽  
pp. 567 ◽  
Author(s):  
Mary Willix Farmer
Keyword(s):  
San Diego ◽  
Language Program ◽  
Total Immersion
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