scholarly journals Induction of classical transplantation tolerance in the adult.

1989 ◽  
Vol 169 (3) ◽  
pp. 779-794 ◽  
Author(s):  
S X Qin ◽  
S Cobbold ◽  
R Benjamin ◽  
H Waldmann
Keyword(s):  
Bone Marrow ◽  
Transplantation Tolerance ◽  
Donor Strain ◽  
Skin Grafts ◽  
Donor Cells ◽  
Transplantation Antigens ◽  
Adult Bone ◽  
Tolerant State ◽  
Clonal Anergy

Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion.

scholarly journals Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue.

1992 ◽  
Vol 175 (1) ◽  
pp. 65-70 ◽  
Author(s):  
T A Barrett ◽  
M L Delvy ◽  
D M Kennedy ◽  
L Lefrancois ◽  
L A Matis ◽  
...  
Keyword(s):  
T Cell Receptor ◽  
Cell Receptor ◽  
Intraepithelial Lymphocytes ◽  
Epithelial Tissue ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Self Tolerance ◽  
Delta Cells ◽  
Clonal Anergy ◽  
Gamma Delta Cells

The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/delta cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-gamma/delta cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.

Maintenance of clonal anergy by endogenously produced IL-10

1994 ◽  
Vol 6 (10) ◽  
pp. 1605-1612 ◽  
Author(s):  
Jürgen C. Becker ◽  
Christian Czerny ◽  
Eva-Bettina Bröcker
Keyword(s):  
Clonal Anergy

scholarly journals Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity

2019 ◽  
Vol 292 (1) ◽  
pp. 61-75 ◽  
Author(s):  
Deborah L. Burnett ◽  
Joanne H. Reed ◽  
Daniel Christ ◽  
Christopher C. Goodnow
Keyword(s):  
B Cell ◽  
Cell Tolerance ◽  
B Cell Tolerance ◽  
Clonal Anergy

Can clonal anergy resist an isotype switch?

1991 ◽  
Vol 1 (3) ◽  
pp. 180-181 ◽  
Author(s):  
Robert S Schwartz
Keyword(s):  
Clonal Anergy
Sign in / Sign up

Export Citation Format

Share Document