1199 Lack of increased frequency of the CC chemokine receptor 5-delta32/delta32 genotype in hepatitis C

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 736-736
Author(s):  
A FLOREANI ◽  
A TOMMASI ◽  
A BARAGIOTTA ◽  
V BALDO ◽  
G TOSITTI ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 5 ◽  
Chemokine Receptor 5

Association of the CC chemokine receptor 5 (CCR5) polymorphisms with preeclampsia in Turkish women

2012 ◽  
Vol 286 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Figen Gurdol ◽  
Leman M. Yurdum ◽  
Ummühan Ozturk ◽  
Elif Isbilen ◽  
Bedia Cakmakoglu
Keyword(s):  
Chemokine Receptor ◽  
Turkish Women ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 5 ◽  
Chemokine Receptor 5

scholarly journals Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

2020 ◽  
Author(s):  
Polina Isaikina ◽  
Ching-Ju Tsai ◽  
Nikolaus Dietz ◽  
Filip Pamula ◽  
Anne Grahl ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Chemokine Receptors ◽  
Binding Mode ◽  
Activation Mechanism ◽  
Structural Basis ◽  
Cc Chemokine ◽  
Gi Protein ◽  
Agonist And Antagonist ◽  
Cc Chemokine Receptor 5 ◽  
Chemokine Receptor 5

AbstractThe human CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor (GPCR) that plays a major role in inflammation and is involved in the pathology of cancer, HIV, and COVID-19. Despite its significance as a drug target, the activation mechanism of CCR5, i.e. how chemokine agonists transduce the activation signal through the receptor, is yet unknown. Here, we report the cryo-EM structure of wild-type CCR5 in an active conformation bound to the chemokine super-agonist [6P4]CCL5 and the heterotrimeric Gi protein. The structure provides the rationale for the sequence-activity relation of agonist and antagonist chemokines. The N-terminus of agonist chemokines pushes onto an aromatic connector that transmits activation to the canonical GPCR microswitch network. This activation mechanism differs significantly from other CC chemokine receptors that bind shorter chemokines in a shallow binding mode and have unique sequence signatures and a specialized activation mechanism.One-sentence summaryThe structure of CCR5 in complex with the chemokine agonist [6P4]CCL5 and the heterotrimeric Gi protein reveals its activation mechanism

scholarly journals CC Chemokine Receptor 5 (CCR5) Desensitization

2010 ◽  
Vol 285 (53) ◽  
pp. 41772-41780 ◽  
Author(s):  
Jean-Michel Escola ◽  
Gabriel Kuenzi ◽  
Hubert Gaertner ◽  
Michelangelo Foti ◽  
Oliver Hartley
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 5 ◽  
Chemokine Receptor 5

scholarly journals Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5)

1999 ◽  
Vol 65 (3) ◽  
pp. 281-285 ◽  
Author(s):  
Heike Olbrich ◽  
Amanda E. I. Proudfoot ◽  
Martin Oppermann
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 5 ◽  
Chemokine Receptor 5

scholarly journals Lipopolysaccharide Inhibits HIV-1 Infection of Monocyte- Derived Macrophages Through Direct and Sustained Down-Regulation of CC Chemokine Receptor 5

2000 ◽  
Vol 164 (5) ◽  
pp. 2592-2601 ◽  
Author(s):  
Giovanni Franchin ◽  
Gabriele Zybarth ◽  
Wei Wei Dai ◽  
Larisa Dubrovsky ◽  
Norbert Reiling ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Down Regulation ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 5 ◽  
Hiv 1 ◽  
Chemokine Receptor 5
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