scholarly journals Tolerance and bystander suppression, with involvment of CD25-positive cells, is induced in rats receiving serum from ovalbumin-fed donors

Immunology ◽  
2000 ◽  
Vol 100 (3) ◽  
pp. 326-333 ◽  
Author(s):  
M. R. Karlsson ◽  
H. Kahu ◽  
L. A. Hanson ◽  
E. Telemo ◽  
U. I. Dahlgren
Keyword(s):  
Bystander Suppression

scholarly journals Bystander suppression of occupational hapten sensitization in rats made tolerant to ovalbumin

1998 ◽  
Vol 12 (4) ◽  
pp. 889-894 ◽  
Author(s):  
T. Pullerits ◽  
S. Lundin ◽  
Z-H. Cui ◽  
U. Dahlgren ◽  
E. Telemo ◽  
...  
Keyword(s):  
Bystander Suppression

Bystander suppression to unrelated allergen sensitization through intranasal administration of tolerogenic exosomes in mouse

2010 ◽  
Vol 47 (11-12) ◽  
pp. 2148-2151 ◽  
Author(s):  
Noela Prado ◽  
Marta Cañamero ◽  
Mayte Villalba ◽  
Rosalía Rodríguez ◽  
Eva Batanero
Keyword(s):  
Intranasal Administration ◽  
Allergen Sensitization ◽  
Bystander Suppression

scholarly journals Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells

2004 ◽  
Vol 101 (16) ◽  
pp. 6116-6121 ◽  
Author(s):  
B. J. Marsland ◽  
N. L. Harris ◽  
M. Camberis ◽  
M. Kopf ◽  
S. M. Hook ◽  
...  
Keyword(s):  
T Cells ◽  
Airway Inflammation ◽  
Cd8 T Cells ◽  
Allergic Airway Inflammation ◽  
Memory Cd8 T Cells ◽  
Bystander Suppression

Bystander Suppression in Food Allergy

2013 ◽  
Vol 131 (2) ◽  
pp. AB92
Author(s):  
Megan S. Motosue ◽  
Tina Dominquez ◽  
Alicia Sciancalepore ◽  
Daniela Pineda ◽  
Anjuli Mehrotra ◽  
...  
Keyword(s):  
Food Allergy ◽  
Bystander Suppression

Bystander suppression induced by oral tolerance

1997 ◽  
Vol 148 (8-9) ◽  
pp. 541-554 ◽  
Author(s):  
M.G. von Herrath
Keyword(s):  
Oral Tolerance ◽  
Bystander Suppression

scholarly journals Antigen-driven bystander suppression after oral administration of antigens.

1991 ◽  
Vol 174 (4) ◽  
pp. 791-798 ◽  
Author(s):  
A Miller ◽  
O Lider ◽  
H L Weiner
Keyword(s):  
T Cells ◽  
Oral Administration ◽  
Cd8 T Cells ◽  
Peripheral Tolerance ◽  
Cell Contact ◽  
Antigen Specificity ◽  
Lewis Rats ◽  
Bystander Suppression

Suppression of experimental autoimmune encephalomyelitis (EAE) in Lewis rats by the oral administration of myelin basic protein (MBP) is mediated by CD8+ T cells that can be isolated from the spleens of MBP-fed animals. These cells adoptively transfer protection to naive animals subsequently immunized with MBP and complete Freund's adjuvant (CFA) and suppress in vitro MBP proliferative responses. Using a transwell system in which the modulator spleen cells from MBP-fed animals are separated by a semipermeable membrane from responder cells, MBP, or OVA-specific T cell lines, we have found that cell contact is not required for in vitro suppression to occur. In vitro suppression is dependent, however, upon antigen-specific triggering of modulator T cells. Once antigen-specific triggering occurs, suppression across the transwell is mediated by an antigen-nonspecific soluble factor that equally suppresses an MBP line or an ovalbumin (OVA) line. This phenomenon of antigen-driven bystander suppression was also demonstrated in vivo. Specifically, Lewis rats fed OVA which were then immunized with MBP/CFA plus OVA given separately subcutaneously were protected from EAE. Animals fed OVA and then immunized with MBP/CFA without OVA given subcutaneously were not protected. The protective effect of feeding OVA could be adoptively transferred by CD8+ T cells from OVA-fed animals into MBP/CFA plus OVA-injected animals. Feeding bovine serum albumin (BSA) or keyhole limpet hemocyanin did not suppress EAE in animals immunized with MBP/CFA plus OVA. EAE was suppressed, however, if BSA was fed and animals then immunized with MBP/CFA plus BSA given subcutaneously. Antigen-driven bystander suppression appears to be an important mechanism by which antigen-driven peripheral tolerance after oral administration of antigen is mediated, and presumably occurs in the microenvironment accounting for the antigen specificity of suppression generated by oral tolerization to antigens.

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