scholarly journals Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA

2007 ◽  
Vol 8 (1) ◽  
pp. 58 ◽  
Author(s):  
Mark W Murphy ◽  
David Zarkower ◽  
Vivian J Bardwell
Keyword(s):  
Dna Sequences ◽  
Dm Domain

scholarly journals Sex-Determining Gene(s) on Distal 9p: Clinical and Molecular Studies in Six Cases*

2000 ◽  
Vol 85 (9) ◽  
pp. 3094-3100 ◽  
Author(s):  
Koji Muroya ◽  
Torayuki Okuyama ◽  
Keiji Goishi ◽  
Yoshifumi Ogiso ◽  
Shin Fukuda ◽  
...  
Keyword(s):  
Wide Spectrum ◽  
External Genitalia ◽  
Chromosome 9 ◽  
Severe Malnutrition ◽  
Female Case ◽  
Dm Domain ◽  
Baseline Values ◽  
Male External Genitalia ◽  
Female External Genitalia

Abstract We report on clinical and molecular findings in five karyotypic males (cases 1–5) and one karyotypic female (case 6) with distal 9p monosomy. Cases 1–3 and 6 had female external genitalia, case 4 showed ambiguous external genitalia, and case 5 exhibited male external genitalia with left cryptorchidism and right intrascrotal testis. Gonadal explorations at gonadectomy in cases 3 and 4 revealed that case 3 had left streak gonad and right agonadism, and case 4 had bilateral hypoplastic testes. Endocrine studies in cases 1–4 and 6 showed that cases 1, 3, and 6 had definite primary hypogonadism, with basal FSH levels of 54, 39, and 41 IU/L, respectively, whereas case 2 with severe malnutrition was unremarkable for the baseline values, and case 4 had fairly good testicular function. Fluorescence in situ hybridization and microsatellite analyses demonstrated that all cases had hemizygosity of the 9p sex-determining region distal to D9S1779, with loss of the candidate sex-determining genes DMRT1 and DMRT2 from the abnormal chromosome 9. Sequence analysis in cases 1–4 and 6 showed that they had normal sequences of each exon of DMRT1 and the DM domain of DMRT2 on the normal chromosome 9, and that cases 1–4 had normal SRY sequence. The results provide further support for the presence of a sex-determining gene(s) on distal 9p and favor the possibility of DMRT1 and/or DMRT2 being the sex-determining gene(s). Furthermore, as hemizygosity of the 9p sex-determining region was associated with a wide spectrum of gonadogenesis from agonadism to testis formation in karyotypic males and with primary hypogonadism regardless of karyotypic sex, it is inferred that haploinsufficiency of the 9p sex-determining gene(s) primarily hinders the formation of indifferent gonad, leading to various degrees of defective testis formation in karyotypic males and impaired ovary formation in karyotypic females.

Evolutionary Dynamics of the DM Domain Gene Family in Metazoans

2003 ◽  
Vol 57 (0) ◽  
pp. S241-S249 ◽  
Author(s):  
Jean-Nicolas Volff ◽  
David Zarkower ◽  
Vivian J. Bardwell ◽  
Manfred Schartl
Keyword(s):  
Gene Family ◽  
Evolutionary Dynamics ◽  
Dm Domain

scholarly journals The DM Domain Transcription Factor MAB-3 Regulates Male Hypersensitivity to Oxidative Stress in Caenorhabditis elegans

2010 ◽  
Vol 30 (14) ◽  
pp. 3453-3459 ◽  
Author(s):  
Hideki Inoue ◽  
Eisuke Nishida
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Sex Determination ◽  
Target Genes ◽  
Stress Sensitivity ◽  
Gata Factor ◽  
X Chromosomes ◽  
C Elegans ◽  
Dm Domain

ABSTRACT Sex differences occur in most species and involve a variety of biological characteristics. The nematode Caenorhabditis elegans consists of two sexes, self-fertile hermaphrodites (XX) and males (XO). Males differ from hermaphrodites in morphology, behavior, and life span. Here, we find that male C. elegans worms are much more sensitive than hermaphrodites to oxidative stress and show that the DM domain transcription factor MAB-3 plays a pivotal role in determining this male hypersensitivity. The hypersensitivity to oxidative stress does not depend on the dosage of X chromosomes but is determined by the somatic sex determination pathway. Our analyses show that the male hypersensitivity is controlled by MAB-3, one of the downstream effectors of the master terminal switch TRA-1 in the sex determination pathway. Moreover, we find that MAB-3 suppresses expression of several transcriptional target genes of the ELT-2 GATA factor, which is a global regulator of transcription in the C. elegans intestine, and show that RNA interference (RNAi) against elt-2 increases sensitivity to oxidative stress. These results strongly suggest that the DM domain protein MAB-3 regulates oxidative stress sensitivity by repressing transcription of ELT-2 target genes in the intestine.

scholarly journals The DM domain protein DMRT1 is a dose-sensitive regulator of germ cell pluripotency

2009 ◽  
Vol 331 (2) ◽  
pp. 419 ◽  
Author(s):  
Tony Krentz ◽  
Mark Murphy ◽  
Vivian Bardwell ◽  
David Zarkower
Keyword(s):  
Germ Cell ◽  
Dm Domain ◽  
Domain Protein

scholarly journals The Mammalian DM Domain Transcription Factor Dmrta2 Is Required for Early Embryonic Development of the Cerebral Cortex

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e46577 ◽  
Author(s):  
Daijiro Konno ◽  
Misato Iwashita ◽  
Yoshiaki Satoh ◽  
Asuka Momiyama ◽  
Takaya Abe ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cerebral Cortex ◽  
Embryonic Development ◽  
Early Embryonic Development ◽  
Dm Domain

CLONING AND SEQUENCING DM DOMAIN OF THE DMRT GENE-FROM THE CHINESE GIANT SALAMANDER,ANDRIAS DAVIDIANUS

2009 ◽  
Vol 33 (1) ◽  
pp. 89-93
Author(s):  
Tiao-Yi XIAO ◽  
Bao-Lin WU ◽  
Xi-Kai GE ◽  
Jian-Ming SU ◽  
Kai-Jian CHEN ◽  
...  
Keyword(s):  
Cloning And Sequencing ◽  
Andrias Davidianus ◽  
Dm Domain ◽  
Chinese Giant Salamander ◽  
I Gene
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