scholarly journals Pin1 and PKM  Sequentially Control Dendritic Protein Synthesis

2010 ◽  
Vol 3 (112) ◽  
pp. ra18-ra18 ◽  
Author(s):  
P. R. Westmark ◽  
C. J. Westmark ◽  
S. Wang ◽  
J. Levenson ◽  
K. J. O'Riordan ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Dendritic Protein Synthesis

Protein Synthesis and Synapse Specificity in Functional Plasticity

2019 ◽  
Author(s):  
Radha Raghuraman ◽  
Amrita Benoy ◽  
Sreedharan Sajikumar
Keyword(s):  
Protein Synthesis ◽  
Molecular Mechanisms ◽  
Long Term Potentiation ◽  
Synaptic Activity ◽  
Long Term Memory ◽  
Term Potentiation ◽  
Synaptic Tagging And Capture ◽  
Dendritic Protein Synthesis ◽  
Related Proteins

This chapter discusses the role of protein synthesis in the maintenance of long-term potentiation (LTP) and its associative properties, synaptic tagging and capture, which are cellular correlates of long-term memory. Starting from a brief overview of the early and late phases of LTP, the chapter discusses various existing models for synaptic activity-induced protein synthesis and its roles in late-LTP. The synaptic tagging and capture and cross-tagging theories are given emphasis, along with the elucidation of local dendritic protein synthesis and its significance in the maintenance of LTP. Inverse synaptic tagging, synaptic competition for plasticity-related proteins, and metaplasticity are also covered. The importance of the balance between proteasomal degradation and synthesis of plasticity-related proteins in persistent potentiation is briefly discussed. This chapter touches upon the physiological implications of epigenetic regulation in the control of neuronal functions and the molecular mechanisms within the neurons that translate epigenetic changes into long-lasting responses.

scholarly journals Calpain-2-Mediated PTEN Degradation Contributes to BDNF-Induced Stimulation of Dendritic Protein Synthesis

2013 ◽  
Vol 33 (10) ◽  
pp. 4317-4328 ◽  
Author(s):  
V. Briz ◽  
Y.-T. Hsu ◽  
Y. Li ◽  
E. Lee ◽  
X. Bi ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Calpain 2 ◽  
Dendritic Protein Synthesis ◽  
Stimulation Of
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