scholarly journals Vitamin A as a Transcriptional Regulator of Cardiovascular Disease

Hearts ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 126-145
Author(s):  
Robert S. Leigh ◽  
Bogac L. Kaynak
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin A ◽  
Nutrient Deficiency ◽  
Cardiac Regeneration ◽  
Pathological Hypertrophy ◽  
Hematological Cancers ◽  
Pharmacological Studies ◽  
Hypertrophy Of The Heart ◽  
Exogenous Delivery ◽  
The Relationship

Vitamin A is a micronutrient and signaling molecule that regulates transcription, cellular differentiation, and organ homeostasis. Additionally, metabolites of Vitamin A are utilized as differentiation agents in the treatment of hematological cancers and skin disorders, necessitating further study into the effects of both nutrient deficiency and the exogenous delivery of Vitamin A and its metabolites on cardiovascular phenotypes. Though vitamin A/retinoids are well-known regulators of cardiac formation, recent evidence has emerged that supports their role as regulators of cardiac regeneration, postnatal cardiac function, and cardiovascular disease progression. We here review findings from genetic and pharmacological studies describing the regulation of both myocyte- and vascular-driven cardiac phenotypes by vitamin A signaling. We identify the relationship between retinoids and maladaptive processes during the pathological hypertrophy of the heart, with a focus on the activation of neurohormonal signaling and fetal transcription factors (Gata4, Tbx5). Finally, we assess how this information might be leveraged to develop novel therapeutic avenues.

scholarly journals A CASE OF GREAT HYPERTROPHY OF THE HEART.

The Lancet ◽  
1854 ◽  
Vol 64 (1625) ◽  
pp. 332-334 ◽  
Author(s):  
William Sedgwick
Keyword(s):  
Hypertrophy Of The Heart

Cardiac Hypertrophy in Rats and Mice Given 3, 3', 5-Triiodo-L-Thyronine Orally

1958 ◽  
Vol 195 (2) ◽  
pp. 385-390 ◽  
Author(s):  
Chalmers L. Gemmill
Keyword(s):  
Drinking Water ◽  
Cardiac Hypertrophy ◽  
Water Content ◽  
Hypertrophy Of The Heart ◽  
Rats And Mice

The giving of 3,3',5-triiodo-l-thyronine in the drinking water produces marked metabolic and circulatory changes. These effects produce hypertrophy of the heart. The water content of the hypertrophied hearts does not change. The hypertrophy of the heart is obtained in both rats and mice. In the rat, following removal of the T-3, there is a return of the heart to approximately the normal size.

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