digital multiplex hierarchy

2011 ◽  
Keyword(s):  
Digital Multiplex

scholarly journals High-Throughput Copy Number Profiling by Digital Multiplex Ligation-Dependent Probe Amplification in Multiple Myeloma

2018 ◽  
Vol 20 (6) ◽  
pp. 777-788 ◽  
Author(s):  
Szabolcs Kosztolányi ◽  
Richárd Kiss ◽  
Lilit Atanesyan ◽  
Ambrus Gángó ◽  
Karel de Groot ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
High Throughput ◽  
Copy Number ◽  
Dependent Probe ◽  
Digital Multiplex

scholarly journals Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia

2017 ◽  
Vol 19 (5) ◽  
pp. 659-672 ◽  
Author(s):  
Anne Benard-Slagter ◽  
Ilse Zondervan ◽  
Karel de Groot ◽  
Farzaneh Ghazavi ◽  
Virinder Sarhadi ◽  
...  
Keyword(s):  
B Cell ◽  
Copy Number ◽  
Lymphoblastic Leukemia ◽  
Copy Number Alterations ◽  
Dependent Probe ◽  
Digital Multiplex

scholarly journals Digital multiplex ligation assay for highly multiplexed screening of β-lactamase-encoding genes in bacterial isolates

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Manu Tamminen ◽  
Jenny Spaak ◽  
Lea Caduff ◽  
Hanna Schiff ◽  
Ramon Lang ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Target Gene ◽  
Low Cost ◽  
Simultaneous Detection ◽  
Bacterial Isolates ◽  
Cost Efficient ◽  
Encoding Genes ◽  
Multiple Target Gene ◽  
Current Screening ◽  
Digital Multiplex

AbstractIncreasing incidence of antibiotic resistance in clinical and environmental settings calls for increased scalability in their surveillance. Current screening technologies are limited by the number of samples and genes that can easily be screened. We demonstrate here digital multiplex ligation assay (dMLA) as a low-cost targeted genomic detection workflow capable of highly-parallel screening of bacterial isolates for multiple target gene regions simultaneously. Here, dMLA is used for simultaneous detection of 1187 β-lactamase-encoding genes, including extended spectrum β-lactamase (ESBL) genes, in 74 bacterial isolates. We demonstrate dMLA as a light-weight and cost-efficient workflow which provides a highly scalable tool for antimicrobial resistance surveillance and is also adaptable to genetic screening applications beyond antibiotic resistance.

Abstract B30: Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome

2018 ◽  
Author(s):  
Artur Mezheyeuski ◽  
Christian Bergsland ◽  
Max Backman ◽  
Tobias Sjöblom ◽  
Ragnhild A. Lothe ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Tumor Stroma ◽  
Immunofluorescence Analysis ◽  
Digital Multiplex
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