Stress Effects During Intense Training on Cellular Immunity, Hormones and Respiratory Infections

2012 ◽  
Keyword(s):  
Cellular Immunity ◽  
Respiratory Infections ◽  
Stress Effects ◽  
Intense Training

Effects of Combined Stress during Intense Training on Cellular Immunity, Hormones and Respiratory Infections

2005 ◽  
Vol 12 (3) ◽  
pp. 164-172 ◽  
Author(s):  
Danielle Gomez-Merino ◽  
Catherine Drogou ◽  
Mounir Chennaoui ◽  
Eve Tiollier ◽  
Jacques Mathieu ◽  
...  
Keyword(s):  
Cellular Immunity ◽  
Respiratory Infections ◽  
Combined Stress ◽  
Intense Training

scholarly journals Importance of cellular immunity link for efficiency of replacement therapy in common variable immune deficiency

2020 ◽  
Vol 22 (4) ◽  
pp. 799-804
Author(s):  
L. P. Sizyakina ◽  
I. I. Andreeva ◽  
D. I. Danilova
Keyword(s):  
Immune Response ◽  
Replacement Therapy ◽  
Cellular Immunity ◽  
Bacterial Infections ◽  
Immune Cell ◽  
Respiratory Infections ◽  
Combined Treatment ◽  
Ivig Therapy ◽  
Continuous Treatment ◽  
Cellular Immune

Lifetime use of IgG replacement therapy  is the standard of CVID treatment. However, full control over stabilization of chronic infection loci is not always achieved, even if this therapy  is continuously applied. The purpose  of this study was to carry out comparative analysis of changes  in cellular  component of adaptive and  innate immune response, depending on effectiveness of replacement therapy  of patients with infectious CVID  phenotype. The  observation group  consisted of 15 patients with  CVID  who  were  diagnosed since early childhood in 100% of cases. They had prolonged respiratory infections followed by the development of complications requiring continuous treatment with antibiotics.After  reaching mean  age of 15 years  old,  the  intensity of infection-associated antibody deficiency was 6-8  times  per year. After verification of the  diagnosis, the  patients received  replacement therapy, first at the saturation dose,  and,  after stabilization of IgG  at the level of 7-8 g/l,  at the monthly maintenance dose. The clinical  course  of the disease was traced  during  a full year of replacement therapy, and the cellular  immunity indices  were evaluated. In all patients, after a year of therapy  corresponding to clinical  guidelines, there  was an improvement in quality  of life indices, decreased rates of recurrent bacterial infections. At the same time, 40% of them continued to suffer, on average, 5.4±1.1 times a year and required long-term courses of antibiotic therapy. Evaluation of immune status did not reveal statistically significant  differences in IgG plasma saturation between the groups of patients with different treatment efficiency: 8.7 (8-9) g/l and 9.1 (8.5-10.5) g/l, at p = 0.5. The  differences related  to immune cell factors  in cases of smaller  effect of IVIG  therapy  are manifested in higher  relative  numbers of T effectors  containing lytic Granzyme B granules  and CD14+CD284+  monocytes, accompanied by lower spontaneous active  oxygen forms produced by neutrophils, lesser contents of CD16+ natural killers in peripheral blood.The obtained data illustrate the value of monitoring, not only serum  IgG  level, but also the parameters of the  cellular  immune response. Such  analysis  may be essential  as a prognostic criterion for efficacy  of IVIG therapy. Reduced levels of some parameters of innate immunity cells serves a basis to formulate the concept of combined treatment and usage of tools that alter functions of immunocompetent cells.

Intense training: mucosal immunity and incidence of respiratory infections

2004 ◽  
Vol 93 (4) ◽  
pp. 421-428 ◽  
Author(s):  
E. Tiollier ◽  
D. Gomez-Merino ◽  
P. Burnat ◽  
J.-C. Jouanin ◽  
C. Bourrilhon ◽  
...  
Keyword(s):  
Mucosal Immunity ◽  
Respiratory Infections ◽  
Intense Training

Spontaneous Cataract in Nude Athymic Mice

1977 ◽  
Vol 35 ◽  
pp. 512-513
Author(s):  
Ronald H. Bradley ◽  
R. S. Berk ◽  
L. D. Hazlett
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Nude Mouse ◽  
Cellular Immunity ◽  
Phosphate Buffer ◽  
Osmium Tetroxide ◽  
Athymic Mice ◽  
Transmission Microscopy ◽  
Mouse Lens ◽  
Scanning Electron

The nude mouse is a hairless mutant (homozygous for the mutation nude, nu/nu), which is born lacking a thymus and possesses a severe defect in cellular immunity. Spontaneous unilateral cataractous lesions were noted (during ocular examination using a stereomicroscope at 40X) in 14 of a series of 60 animals (20%). This transmission and scanning microscopic study characterizes the morphology of this cataract and contrasts these data with normal nude mouse lens.All animals were sacrificed by an ether overdose. Eyes were enucleated and immersed in a mixed fixative (1% osmium tetroxide and 6% glutaraldehyde in Sorenson's phosphate buffer pH 7.4 at 0-4°C) for 3 hours, dehydrated in graded ethanols and embedded in Epon-Araldite for transmission microscopy. Specimens for scanning electron microscopy were fixed similarly, dehydrated in graded ethanols, then to graded changes of Freon 113 and ethanol to 100% Freon 113 and critically point dried in a Bomar critical point dryer using Freon 13 as the transition fluid.

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