Comparison of the Renin Response to Dopamine and Noradrenaline in Normal Subjects and Patients with Autonomic Insufficiency

1974 ◽  
Vol 46 (4) ◽  
pp. 481-488 ◽  
Author(s):  
C. S. Wilcox ◽  
M. J. Aminoff ◽  
A. B. Kurtz ◽  
J. D. H. Slater
Keyword(s):  
Autonomic Failure ◽  
Sodium Intake ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Control Groups ◽  
Autonomic Reflexes ◽  
Fractional Increase ◽  
The Mean ◽  
Autonomic Insufficiency ◽  
Stimulation Of

1. The effect on plasma renin activity (PRA) of dopamine and noradrenaline infusions was studied in three patients with Shy—Drager syndrome, three patients with Parkinson's disease and normal autonomic reflexes, and three healthy volunteers. The patients with the Shy—Drager syndrome had functional evidence of a peripheral lesion of the sympathetic nervous system and subnormal PRA on a controlled sodium intake. 2. In all subjects catecholamines were infused step-wise for 4 min until a 30% rise in systolic blood pressure occurred. 3. In each subject, PRA fell after noradrenaline but rose after dopamine. The mean fractional increase in PRA after dopamine was no less in the Shy—Drager patients than in the control groups. 4. The results suggest, first, that stimulation of dopamine receptors can release renin, and secondly, that inadequate renin stores cannot explain the low PRA found in our patients with autonomic failure.

Alpha sympathomimetic treatment of autonomic insufficiency with orthostatic hypotension

1995 ◽  
Vol 99 (6) ◽  
pp. 604-610 ◽  
Author(s):  
Fetnat M. Fouad-Tarazi ◽  
Masanori Okabe ◽  
Hershel Goren
Keyword(s):  
Orthostatic Hypotension ◽  
Autonomic Insufficiency

Idiopathic orthostatic hypotension: Circulatory dynamics in chronic autonomic insufficiency

1974 ◽  
Vol 34 (3) ◽  
pp. 288-294 ◽  
Author(s):  
M.Mohsen Ibrahim ◽  
Robert C. Tarazi ◽  
Harriet P. Dustan ◽  
Emmanuel L. Brav
Keyword(s):  
Orthostatic Hypotension ◽  
Idiopathic Orthostatic Hypotension ◽  
Autonomic Insufficiency ◽  
Circulatory Dynamics

Autonomic Insufficiency Syndromes

2003 ◽  
Vol 6 (4) ◽  
pp. 170-177
Author(s):  
Ina E. Djonlagic ◽  
Jeffrey A. Cohen
Keyword(s):  
Autonomic Insufficiency

New onset of orthostatic intolerance due to autonomic insufficiency following gastric bypass surgery

Heart Rhythm ◽  
2005 ◽  
Vol 2 (5) ◽  
pp. S111
Author(s):  
Yousef Kanjwal ◽  
Daniel Kosinski ◽  
George Maly ◽  
Mark Kligman ◽  
Blair P. Grubb
Keyword(s):  
Gastric Bypass ◽  
Bypass Surgery ◽  
Orthostatic Intolerance ◽  
Gastric Bypass Surgery ◽  
Autonomic Insufficiency ◽  
New Onset

Radical Autonomic Insufficiency

2010 ◽  
Vol 3 (130) ◽  
pp. ec213-ec213
Author(s):  
N. R. Gough
Keyword(s):  
Autonomic Insufficiency

Autonomic insufficiency

1982 ◽  
Vol 142 (2) ◽  
pp. 339-344 ◽  
Author(s):  
W. L. Henrich
Keyword(s):  
Autonomic Insufficiency

Autonomic Disorders

2017 ◽  
Author(s):  
Karl E. Misulis ◽  
E. Lee Murray
Keyword(s):  
Differential Diagnosis ◽  
Orthostatic Hypotension ◽  
Systemic Disease ◽  
Neurologic Manifestations ◽  
Autonomic Disorders ◽  
Autonomic Insufficiency

Autonomic difficulty is usually a component of a systemic disease with other neurologic manifestations. A commonality is orthostatic hypotension for most of these. Once the diagnosis of autonomic insufficiency has been made, the differential diagnosis includes disorders described in this chapter.

Autonomic Insufficiency

1982 ◽  
Vol 142 (2) ◽  
pp. 339 ◽  
Author(s):  
William L. Henrich
Keyword(s):  
Autonomic Insufficiency

Determination of Noradrenaline Uptake, Spillover to Plasma and Plasma Concentration in Patients with Essential Hypertension

1980 ◽  
Vol 59 (s6) ◽  
pp. 311s-313s ◽  
Author(s):  
M. Esler ◽  
G. Jackman ◽  
P. Leonard ◽  
A. Bobik ◽  
Helen Skews ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Normal Subjects ◽  
Plasma Noradrenaline ◽  
Neuronal Uptake ◽  
Noradrenaline Uptake ◽  
Plasma Noradrenaline Concentration ◽  
Noradrenaline Concentration ◽  
Uptake Of Noradrenaline ◽  
Rapid Removal ◽  
Autonomic Insufficiency

1. The rates of entry of noradrenaline to plasma and of removal of noradrenaline from plasma, and plasma noradrenaline concentration, were determined in normal subjects and in patients with essential hypertension. Neuronal uptake of noradrenaline was assessed from the plasma tritiated noradrenaline disappearance curve, after infusion to steady state. 2. Noradrenaline disappearance was biexponential. Rapid removal was dependent on neuronal uptake, being slowed if neuronal noradrenaline uptake was reduced, either by desipramine in normal subjects, or in patients with sympathetic nerve dysfunction (autonomic insufficiency). 3. In 10 of 41 hypertensive patients the t1 1/2 similarly was prolonged, presumptive evidence of a defect in neuronal noradrenaline uptake. Endogenous noradrenaline escaping uptake after release, and spilling over into plasma, and plasma noradrenaline concentration, were increased in these patients. 4. Defective neuronal uptake of noradrenaline, by exposing adrenoreceptors to high local transmitter concentration, may be important in the pathogenesis of essential hypertension in some patients.

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