Iodine-related Disease States

2012 ◽  
Keyword(s):  
Related Disease ◽  
Disease States

Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states

2004 ◽  
Vol 89-90 ◽  
pp. 187-193 ◽  
Author(s):  
André G. Uitterlinden ◽  
Yue Fang ◽  
Joyce B.J. van Meurs ◽  
Hans van Leeuwen ◽  
Huibert A.P. Pols
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Related Disease ◽  
Disease States ◽  
Receptor Gene Polymorphisms

scholarly journals Stress and stress-related disease states as topics of multi-approach research

Stress ◽  
2020 ◽  
Vol 23 (6) ◽  
pp. 615-616
Author(s):  
Daniela Jezova ◽  
James P. Herman
Keyword(s):  
Related Disease ◽  
Disease States

scholarly journals Vasoplegia after cardiopulmonary bypass: A narrative review of pathophysiology and emerging targeted therapies

2020 ◽  
Vol 8 ◽  
pp. 205031212093546
Author(s):  
Theresa J Barnes ◽  
Maxwell A Hockstein ◽  
Craig S Jabaley
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiopulmonary Bypass ◽  
The United States ◽  
Narrative Review ◽  
Therapeutic Interventions ◽  
Related Disease ◽  
Disease States ◽  
Pathophysiologic Mechanisms

Cardiovascular disease remains the leading cause of death in the United States, and cardiopulmonary bypass is a cornerstone in the surgical management of many related disease states. Pathophysiologic changes associated both with extracorporeal circulation and shock can beget a syndrome of low systemic vascular resistance paired with relatively preserved cardiac output, termed vasoplegia. While increased vasopressor requirements accompany vasoplegia, related pathophysiologic mechanisms may also lead to true catecholamine resistance, which is associated with further heightened mortality. The introduction of a second non-catecholamine vasopressor, angiotensin II, and non-specific nitric oxide scavengers offers potential means by which to manage this challenging phenomenon. This narrative review addresses both the definition, risk factors, and pathophysiology of vasoplegia and potential therapeutic interventions.

Iodine-related Disease States

2009 ◽  
pp. 1082-1083
Author(s):  
Stanley M. Gartler ◽  
R. Scott Hansen ◽  
Vinzenz Oji ◽  
Heiko Traupe ◽  
Julia Horn ◽  
...  
Keyword(s):  
Related Disease ◽  
Disease States

scholarly journals Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Huaping Xu ◽  
Xiaoyun Shi ◽  
Xin Li ◽  
Jiexin Zou ◽  
Chunyan Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mast Cell ◽  
Mast Cells ◽  
Neural Control ◽  
Inflammatory Responses ◽  
The Body ◽  
Mast Cell Activation ◽  
Cell Functions ◽  
Related Disease ◽  
Disease States

AbstractThe existence of the neural control of mast cell functions has long been proposed. Mast cells (MCs) are localized in association with the peripheral nervous system (PNS) and the brain, where they are closely aligned, anatomically and functionally, with neurons and neuronal processes throughout the body. They express receptors for and are regulated by various neurotransmitters, neuropeptides, and other neuromodulators. Consequently, modulation provided by these neurotransmitters and neuromodulators allows neural control of MC functions and involvement in the pathogenesis of mast cell–related disease states. Recently, the roles of individual neurotransmitters and neuropeptides in regulating mast cell actions have been investigated extensively. This review offers a systematic review of recent advances in our understanding of the contributions of neurotransmitters and neuropeptides to mast cell activation and the pathological implications of this regulation on mast cell–related disease states, though the full extent to which such control influences health and disease is still unclear, and a complete understanding of the mechanisms underlying the control is lacking. Future validation of animal and in vitro models also is needed, which incorporates the integration of microenvironment-specific influences and the complex, multifaceted cross-talk between mast cells and various neural signals. Moreover, new biological agents directed against neurotransmitter receptors on mast cells that can be used for therapeutic intervention need to be more specific, which will reduce their ability to support inflammatory responses and enhance their potential roles in protecting against mast cell–related pathogenesis.

DNA nick end labeling: a reliable marker for apoptosis?

1995 ◽  
Vol 53 ◽  
pp. 962-963
Author(s):  
Anne F. Bushnell ◽  
Sarah Webster ◽  
Lynn S. Perlmutter
Keyword(s):  
Cell Death ◽  
Cultured Cells ◽  
Apoptotic Cell ◽  
Morphological Characteristics ◽  
Detection Methods ◽  
Tissue Preparation ◽  
Preparation Methods ◽  
Dna Laddering ◽  
Disease States ◽  
Reliable Marker

Apoptosis, or programmed cell death, is an important mechanism in development and in diverse disease states. The morphological characteristics of apoptosis were first identified using the electron microscope. Since then, DNA laddering on agarose gels was found to correlate well with apoptotic cell death in cultured cells of dissimilar origins. Recently numerous DNA nick end labeling methods have been developed in an attempt to visualize, at the light microscopic level, the apoptotic cells responsible for DNA laddering.The present studies were designed to compare various tissue processing techniques and staining methods to assess the occurrence of apoptosis in post mortem tissue from Alzheimer's diseased (AD) and control human brains by DNA nick end labeling methods. Three tissue preparation methods and two commercial DNA nick end labeling kits were evaluated: the Apoptag kit from Oncor and the Biotin-21 dUTP 3' end labeling kit from Clontech. The detection methods of the two kits differed in that the Oncor kit used digoxigenin dUTP and anti-digoxigenin-peroxidase and the Clontech used biotinylated dUTP and avidinperoxidase. Both used 3-3' diaminobenzidine (DAB) for final color development.

The Concepts of Prevalence and Incidence as Applied to the Study of Development and Duration of Disease

1968 ◽  
Vol 7 (02) ◽  
pp. 111-117 ◽  
Author(s):  
M. Kashgahian
Keyword(s):  
Mass Screening ◽  
Disease Process ◽  
Incidence Data ◽  
Disease States ◽  
History Of ◽  
Duration Of Disease ◽  
Process Methodology

The proper use of prevalence and incidence data can result in an effective way to study the history of the disease process. Methodology is given whereby the progression, duration and transition of diseases can be elucidated. Prevalence and incidence have been redefined and used in an unconventional way in view of new types of data which are being generated by mass screening projects for disease which are able to discover presymptomatic and preclinical disease states.

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